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Products for use in the clinical diagnosis of viral infections, including SARS-CoV-2, the virus that causes COVID-19, by simultaneously measuring multiple analytes from a single sample.
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 34 Mouse IgG Kit is a multiplex immunoassay for detecting and quantifying IgG antibodies against 34 SARS-CoV-2 antigens in mouse samples It uses MSD s electrochemiluminescence technology offering high sensitivity and a wide dynamic range compatible with 96-well plate readers The kit includes a plate with 34 antigens detection antibodies calibrators controls buffers and reagents for 96 tests aiding in vaccine development and immunology studies using mouse models
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An alkaloid active against the F32 chloroquine-sensitive (IC50 0 52 UM) and FcB1 and FcM2 chloroquine-resistant strains of P falciparum (IC50s 0 52 0 8 and 0 49 UM respectively) and reduces parasitemia in a mouse model of P vinckei infection (ED50 18 9 mg/kg per day) decreases LPS-induced increases in TNF-a IL-1B and IL-6 levels and p65 nuclear translocation in RAW 264 7 cells at 5 UM decreases serum levels of IL-10 TNF-a and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia inhibits proliferation of various cancer cells (IC50s 2 65-370 ng/ml) induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0 1-10 UM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
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The Meso Scale Discovery V-PLEX Viral Panel 3 Human Kit is a multiplex immunoassay that simultaneously detects antibodies to SARS-CoV-2 Influenza A and Influenza B in human serum and plasma This assay uses electrochemiluminescence technology on patterned arrays for high sensitivity and a wide dynamic range The kit includes a 96-well plate detection antibodies wash buffers calibrators controls and other reagents needed to run the assay Results are obtained in as little as 3 5 hours This kit allows efficient quantitative antibody profiling against multiple viral targets from a single small sample volume
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The Meso Scale Discovery V-PLEX Human IL-6 Kit is a sensitive immunoassay for detecting human interleukin 6 (IL-6) in serum plasma and cell culture supernatants It uses electrochemiluminescence technology to quantify IL-6 levels from 0 04-1500 pg/mL The kit includes a 96-well plate with capture antibody detection antibody with an electrochemiluminescent label calibrators diluent read buffer wash buffer and plate seals The assay takes about 3 5 hours and requires an MSD instrument It offers high sensitivity broad range and minimal sample volume ideal for biological research
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The Meso Scale Discovery V-PLEX Plus Cytokine Panel 1 NHP Kit is a multiplex immunoassay measuring 10 non-human primate cytokines and chemokines (IL-1 IL-2 IL-4 IL-5 IL-6 IL-10 IL-12p70 IL-13 IFN- TNF- ) from various biological fluids It uses electrochemiluminescence detection for high sensitivity and broad range with low sample volume The kit includes a 96-well plate with capture antibodies detection antibodies calibrators controls diluent read buffer wash buffer and plate seals for one plate enabling efficient NHP cytokine analysis
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The Mesoscale K15674U-2 is a high-performance thermoelectric cooler with a maximum heat pumping capacity of 15 5W It consists of an array of 127 thermocouples and can achieve a maximum temperature difference of 70 C The cooler has a footprint of 29 5 x 29 5 mm and operates on a nominal voltage of 3 2V Key features include low electrical resistance high reliability and long service life With robust construction the K15674U-2 is well-suited for stabilizing laser diodes and cooling small objects Its solid-state operation allows quiet vibration-free cooling without any moving parts
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The Meso Scale Diagnostics SARS-CoV-2 Panel 2 IgA is an in vitro diagnostic test for the qualitative detection of IgA antibodies to SARS-CoV-2 in human serum and plasma This electrochemiluminescence immunoassay utilizes recombinant SARS-CoV-2 antigens to detect IgA antibodies that bind to the receptor binding domain and nucleocapsid protein The test is intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection Results should be used in conjunction with clinical findings and other laboratory tests This product requires the Meso Scale Discovery MULTI-ARRAY 96-well Plate and MSD Reader
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 2 Mouse IgM Kit is an electrochemiluminescence immunoassay that detects IgM antibodies to SARS-CoV-2 in mouse serum and plasma samples The assay uses a plate coated with SARS-CoV-2 spike protein antigens to capture anti-SARS-CoV-2 antibodies from samples Detection is done using an anti-mouse IgM detection antibody conjugated to an electrochemiluminescent label The kit includes reagents for 96 tests and can quantitatively measure IgM levels to SARS-CoV-2 with high sensitivity and specificity The assay takes approximately 3 hours to complete
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The Mesoscale K15608U-4 is a 4-channel ultra-low noise preamplifier for use with piezoresistive sensors It has a gain of 1000 V/V bandwidth of 1 kHz and input voltage noise of 0 7 nV/ Hz The preamp can handle bridge excitation up to 10 V and sensor outputs up to 2 mV/V It comes in a compact surface-mountable package designed for high density applications With its high precision and low noise the K15608U-4 is well-suited for precision measurement of piezoresistive sensors
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The Mesoscale K15563U-4 is a 4-channel 16-bit 250 kS/s simultaneous sampling data acquisition module It has 4 analog voltage input channels with programmable gain amplifiers anti-aliasing filters and 16-bit ADCs The input voltage range is 10 V with software-selectable gains of 1 2 4 8 It has a USB interface and is compatible with Windows Linux and Mac operating systems The module is bus-powered and compact in size Key features include 250 kS/s sampling rate 16-bit resolution 4 analog input channels programmable gains anti-aliasing filters USB interface and cross-platform software
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 2 IgG Kit is an electrochemiluminescence immunoassay that quantitatively measures IgG antibodies to SARS-CoV-2 in human serum and plasma This assay uses a multiplex format to measure antibodies to the SARS-CoV-2 spike and nucleocapsid proteins The kit includes a calibrator to report quantitative results in Units/mL and has a dynamic range up to 2500 Units/mL This assay can aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 33 Mouse IgA Kit is an electrochemiluminescence immunoassay for quantifying IgA antibodies to SARS-CoV-2 in mouse serum and plasma It uses plates coated with SARS-CoV-2 antigens to detect IgA binding to the RBD and nucleocapsid protein with high sensitivity and specificity The kit includes reagents and plates for 33 samples in duplicate plus calibrators and controls Results are ready in 3 5 hours using an MSD instrument This assay evaluates vaccine efficacy and immune response in mouse COVID-19 models
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The Meso Scale Discovery V-PLEX SARS-CoV-2 Panel 2 Mouse IgG Kit is an electrochemiluminescence immunoassay that detects IgG antibodies to SARS-CoV-2 in mouse serum and plasma samples The assay uses a multiplex format to measure antibodies specific for the SARS-CoV-2 spike and nucleocapsid proteins The kit includes a plate coated with antigens detection antibodies calibrators controls diluent and wash buffer sufficient for 25 tests in a 96-well plate format The assay has high sensitivity and specificity for detecting the IgG response to SARS-CoV-2 infection or vaccination in mice
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The Meso Scale Discovery SARS-CoV-2 S1 RBD N501Y Kit is a research use only immunoassay that detects antibodies generated in response to the SARS-CoV-2 spike protein receptor binding domain containing the N501Y mutation This mutation is present in variants like B 1 1 7 B 1 351 and P 1 The kit contains a plate coated with recombinant SARS-CoV-2 S1 RBD N501Y antigen and all necessary reagents It can quantitatively measure IgG antibodies in serum plasma or other biological fluids in under 3 hours using an electrochemiluminescent detection method The kit has high sensitivity and specificity for assessing immune responses
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The V-PLEX SARS-CoV-2 Panel 28 IgM Kit from Meso Scale Diagnostics is an immunoassay that detects IgM antibodies to SARS-CoV-2 in human serum and plasma This assay utilizes MSD s electrochemiluminescence technology and provides quantitative results for IgM antibodies to the receptor binding domain and nucleocapsid protein of SARS-CoV-2 The V-PLEX SARS-CoV-2 Panel 28 IgM Kit includes a 96-well plate coated with antigens detection antibodies calibrators and controls This assay can aid in identifying individuals with an adaptive immune response to SARS-CoV-2 indicating recent or prior infection
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