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ACE2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier: Thermo Scientific PA5110613

Catalog No. PIPA5110613

$647.00 / Each of 1

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Description

Immunogen sequence: MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE D

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Specifications

Antigen	ACE2
Classification	Polyclonal
Conjugate	Unconjugated
Gene	ACE2
Gene Alias	2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	59272
Content And Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form	Liquid

Applications	Immunohistochemistry, Western Blot
Concentration	0.1 mg/mL
Formulation	PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.	Q9BYF1
Gene Symbols	ACE2
Immunogen	Recombinant Protein corresonding to Human ACE2
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human
Product Type	Antibody
Isotype	IgG

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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

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ACE2 Polyclonal Antibody, Invitrogen™

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