ACVRL1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5118826

Catalog No. PIPA5118826

Description

Antibody detects endogenous levels of total ACVL1.

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2. Mutations in ACVRL1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

Specifications

• Antigen: ACVRL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACVRL1
• Gene Alias: activin A receptor like type 1, activin A receptor type II-like 1, activin A receptor type IL, activin A receptor, type II-like 1, activin A receptor, type II-like kinase 1, Activin receptor like kinase 1, activin receptor-like kinase 1, activin receptor-like kinase-1, Acvrl1, Acvrlk1, AI115505, AI427544, ALK1, ALK-1, HHT, HHT2, ORW2, R3, R-3, Serine/threonine-protein kinase receptor R3, SETHKIR, SKR3, TGF-B superfamily receptor type I, TSR-I
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11482, 25237, 94
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P37023, P80203, Q61288
• Gene Symbols: ACVRL1
• Immunogen: A synthesized peptide derived from human ACVRL1(Accession P37023), corresponding to amino acid residues G211-A261.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov