Aquaporin 12 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5101434

Catalog No. PIPA5101434

Description

Antibody detects endogenous levels of total AQP12.

Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO). No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.

Specifications

• Antigen: Aquaporin 12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AQP12B
• Gene Alias: AQP12; AQP-12; AQP12A; AQP12B; AQP-12B; AQPX2; aquaporin 12; aquaporin 12A; aquaporin 12B; aquaporin X2; aquaporin-12; aquaporin-12A; Aquaporin-12B; INSSA3; insulin synthesis associated 3; RGD1562727
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 375318, 653437
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: A6NM10, Q8IXF9
• Gene Symbols: AQP12A, AQP12B
• Immunogen: A synthesized peptide derived from human AQP12A(Accession Q8IXF9), corresponding to amino acid residues V232-R282.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG