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Caspase 12 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA585716
Description
Keep as concentrated solution. Positive Control: 293T, A431, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
Specifications
Caspase 12 | |
Polyclonal | |
Unconjugated | |
CASP12 | |
CASP12, CASP-12, CASP12P1, caspase 12, caspase 12 (gene/pseudogene), caspase 12 pseudogene 1, caspase-12, Inactive caspase-12, OTTMUSP00000045799, OTTMUSP00000045802, OTTMUSP00000045803, UNQ9415, UNQ9415/PRO34398 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
100506742 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.13 mg/mL | |
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300, pH 7 | |
Q6UXS9 | |
CASP12 | |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Caspase 12. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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Product Title
Caspase 12 Polyclonal Antibody, Invitrogen™ > 100 μL; Unconjugated
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