KIDINS220 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA14229

Catalog No. PA14229

Description

PA1-4229 detects the Kidins220 protein in human samples. PA1-4229 has been successfully used in Western blot procedures. The PA1-4229 immunogen is a synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of the human 220 kDa Kidins220 protein.

This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: KIDINS220
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kidins220
• Gene Alias: 3110039L19Rik; AI194387; AI316525; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane spanning protein; ankyrin repeat-rich membrane-spanning protein; ARMS; C330002I19Rik; KIAA1250; KIDINS220; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; kinase D-interacting substrate 220; kinase D-interacting substrate 220kDa; kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; mKIAA1250; truncated KIDINS220
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57498
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9ULH0
• Gene Symbols: Kidins220
• Immunogen: Synthetic peptide corresponding to residues A(1747) S S E S T G F G E E R E S I L(1762) of human Kidins220.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG