PCBP2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA598446

Catalog No. PIPA598446

Description

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PCBP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCBP2
• Gene Alias: Alpha CP2, Alpha-CP2, alphaCP-2, AW412548, CBP, CTBP, fb36h02, Heterogeneous nuclear ribonucleoprotein E2, heterogeneous nuclear ribonucleoprotein X, heterogenous nuclear ribonucleoprotein E2, hnRNP E2, hnRNP X, HNRNPE2, hnRNP-E2, Hnrnpx, HNRPE2, Hnrpx, MGC110998, Pcbp2, pcbp2 protein, PCBP3, poly(rC) binding protein 2, poly(rC)-binding protein 2, Putative heterogeneous nuclear ribonucleoprotein X, rCbinding protein 2, wu:fb36h02, zgc:55964
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 5094
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.69 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300, pH 7.4
• Gene Accession No.: Q15366
• Gene Symbols: PCBP2
• Immunogen: Recombinant Human Poly(rC)-binding protein 2 protein (171-293AA)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG