Relaxin 3 Monoclonal Antibody (D10), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA543609

Catalog No. PIMA543609

Description

Relaxin 3 is part of the Relaxin-like peptide family that plays an important neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in long-term control of food intake.

Specifications

• Antigen: Relaxin 3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: Q8BFS3
• Gene Symbols: RLN3
• Immunogen: Recombinant protein Relaxin 3. The antigen corresponds to amino acid range 1-140 of the target protein.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: D10
• Conjugate: Unconjugated
• Gene: RLN3
• Gene Alias: H3; insl7; insulin-like 7; insulin-like peptide 7; Insulin-like peptide INSL7; M3; PRO20213; Prorelaxin H3; prorelaxin M3; relaxin 3; relaxin-3; Relaxin-3 A chain; Relaxin-3 B chain; RLN3; RXN3; UNQ6188; UNQ6188/PRO20213; ZINS4
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 266997
• Content And Storage: -20°C
• Form: Liquid