STEAP3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5102321

Catalog No. PIPA5102321

Description

Antibody detects endogenous levels of total STEA3.

The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.

Specifications

• Antigen: STEAP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STEAP3
• Gene Alias: 1010001D01Rik; AHMIO2; dudlin 2; dudlin-2; dudulin 2; dudulin-2; hpHyde; hTSAP6; Metalloreductase STEAP3; pHyde; Protein nm1054; six-transmembrane epithelial antigen of prostate 3; STEAP family member 3; STEAP family member 3, metalloreductase; STEAP3; STEAP3 metalloreductase; STMP3; TSAP6; tumor suppressor pHyde; tumor suppressor-activated pathway protein 6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170824, 55240, 68428
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5RKL5, Q658P3, Q8CI59
• Gene Symbols: STEAP3
• Immunogen: A synthesized peptide derived from human STEAP3(Accession Q658P3), corresponding to amino acid residues D16-R66.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov