Lipids and Lipid Derivatives
Apexbio Technology LLC Menthol 1490-04-6 100mg
Menthol (CAS 1490-04-6) is a widely used small molecule modulator of the TRPM8 ion channel which is implicated in cold sensation By activating TRPM8 menthol induces a cooling response in sensory neurons It also inhibits neuronal calcium channel currents contributing to its analgesic and anti-irritant properties In animal studies menthol has been shown to reduce aversive responses to oral nicotine administration in mice Due to these pharmacological actions menthol serves as a reference standard in biomedical research focused on pain perception sensory modulation and mechanisms of addiction
Cayman Chemical 14-methyl PalmItIc AcId 20mg
A methylated fatty acid; has been found in bacteria, bovine milk fat, Aegean jellyfish, and one-humped camel meat and fat; found in human breast milk and levels are decreased in mature breast milk compared to colostrum; produced in Florida manatee liver in response to brevetoxin exposure
Apexbio Technology LLC nor-NOHA (acetate) 1140844-63-8 10mg
nor-NOHA (acetate) (CAS 1140844-63-8) is a potent reversible inhibitor of rat liver arginase (Ki 0 5 M) By competitively inhibiting arginase nor-NOHA modulates the cellular balance between the L-arginine-dependent pathways of nitric oxide synthase (NOS) and arginase affecting nitric oxide production and urea cycle metabolism In vitro studies have shown that nor-NOHA suppresses proliferation migration and invasion of HepG2 hepatocellular carcinoma cells induces apoptosis and alters expression of Arg1 MMP-2 P53 and ECD In vivo nor-NOHA improves endothelial function in rat models of inflammation by enhancing NOS activity increasing EDHF and reducing superoxide anion production This compound is widely used to investigate arginase-related mechanisms in cellular and vascular biology
Apexbio Technology LLC Megestrol Acetate 595-33-5 1g
Megestrol Acetate (CAS 595-33-5) is a synthetic progestin utilized to downregulate nuclear and cytoplasmic androgen receptor activity It modulates hormone receptor-mediated processes thereby impacting cellular metabolic and signaling pathways Megestrol Acetate exerts its biological activity primarily by inducing apoptosis and disrupting cell cycle progression In in vitro studies using HepG2 cell lines Megestrol Acetate demonstrates proliferation inhibition with an IC50 value of approximately 260 M Based on these pharmacological properties Megestrol Acetate holds research potential in studies of cancer cachexia hepatocellular carcinoma and the investigation of tumor growth mechanisms