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Eldecalcitol (ED-71) is an orally active vitamin D3 analogue that inhibits bone resorption and increases bone mineral density. It also exhibits an anti-tumor effect, inhibits cell proliferation, migration, and induces apoptosis by suppressing GPx-1.
Orally active vitamin D3 analogue
Inhibits bone resorption and increases bone mineral density
Exhibits anti-tumor effects
Inhibits cell proliferation and migration
Induces apoptosis by suppressing GPx-1
Shows no cytotoxicity at 0-50 nM for 24 hours
Reduces cell death induced by LPS
Inhibits LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1
Arrests cell cycle at G0/G1 phase
Stimulates focal bone formation and suppresses bone resorption
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Phytanic acid-d3 is the deuterium-labeled Phytanic acid. It is an endogenous metabolite found in blood. This compound can be utilized as a tracer and an internal standard for quantitative analysis, and is also explored for its potential impact on pharmacokinetic and metabolic profiles.
Deuterium-labeled form of Phytanic acid
Useful for research related to Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata, and Infantile Refsum Disease
Can serve as a tracer in experiments
Acts as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS
Potential to influence pharmacokinetic and metabolic profiles of drugs through deuterium substitution
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Dopamine D2 receptor agonist-3 is a research compound described as a selective dopamine D2 receptor partial agonist and a dopamine D3 receptor antagonist. It is supplied as a solid powder with documented purity and analytical data for use in in vitro and preclinical receptor pharmacology research.
High purity of 98.3%.
Molecular formula C15H22ClN3O and molecular weight 295.81.
Selective D2 partial agonist and D3 antagonist (pEC50 = 8.3 and <5.5).
Supplied as a solid powder for research use only.
Available in multiple sizes, including 10 MG packaging.
Datasheet and certificate of analysis available.
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Aminoadipic acid-d3 is the deuterium labeled Aminoadipic acid, an intermediate in the metabolism of lysine and saccharopine. Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Ozenoxacin-d3 hydrochloride is the deuterium-labeled isotopic standard of ozenoxacin hydrochloride intended for use as an analytical/internal standard in quantitative assays such as LC-MS/MS. Supplied as the hydrochloride salt, it is suitable for method development, validation, and accuracy assessment in trace-level quantitation.
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trans-Doxercalciferol is a chemical intended for research use only, suitable for laboratory applications and the manufacture of substances. It is a solid that must be handled by qualified scientists in equipped facilities.
For research use only
High purity
Suitable for laboratory applications
Can be used in substance manufacturing
Stable under recommended storage conditions
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Pyrazinamide-d3 (CAS No 1432059-16-9) is a deuterium-labeled derivative used in biomedical research as a stable isotope for various studies Originating from antimicrobial research it is primarily utilized to investigate Mycobacterium tuberculosis the causative agent of tuberculosis Pyrazinamide-d3 acts by disrupting the bacterial membrane potential and interfering with fatty acid synthase I which is critical for the bacterium s survival and replication In vitro studies frequently demonstrate its activity in the nanomolar to low micromolar range making it effective for precise quantitative analysis This compound is commonly applied in cell models animal studies and drug screening assays to measure drug metabolism and pharmacokinetics Experimental concentrations typically depend on the specific research design allowing for flexibility across various experimental frameworks ultimately aiding in the development of novel therapeutics against bacterial infections
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