Solvents
Medchemexpress LLC Thiamphenicol-d3 | 2211914-19-9 | 99.5% | 5 MG
Thiamphenicol-d3 is a deuterium labeled Thiamphenicol, a broad-spectrum antimicrobial antibiotic. It inhibits protein synthesis by binding to the 50S ribosomal subunit, resulting in a bacteriostatic effect against Gram-negative, Gram-positive aerobic, and anaerobic bacteria. This compound is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements incorporated into the drug molecule
- Potential to affect the pharmacokinetic and metabolic profiles of drugs due to deuteration
Medchemexpress LLC Benzyl alcohol-d7 | 71258-23-6 | 99.6% | 100 MG
Benzyl alcohol-d7 is the deuterium-labeled Benzyl alcohol, an aromatic alcohol that appears as a colorless liquid with a mild, pleasant aromatic odor. It is intended for research use only and is not sold to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during the drug development process
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs
Apexbio Technology LLC Linifanib (ABT-869) 796967-16-3 10mM (in 1mL DMSO)
Linifanib (ABT-869 CAS 796967-16-3) is an ATP-competitive inhibitor of receptor tyrosine kinases targeting platelet-derived growth factor (PDGF) and vascular endothelial growth factor receptors (VEGFRs) as well as FMS-like tyrosine kinase 3 (FLT3) including its activating internal tandem duplication (ITD) mutations Linifanib selectively reduces cell growth in FLT3 ITD-expressing cell lines such as Ba/F3 FLT3 ITD cells inhibits phosphorylation of FLT3 and Akt and induces apoptosis preferentially in ITD mutant cells In vivo experiments with ITD-expressing leukemia xenografts show reduced leukemia progression and prolonged survival in mice treated orally with linifanib This compound is widely used in preclinical research for acute myeloid leukemia studies
Apexbio Technology LLC RO4929097(Synonyms: RO-4929097, RO 4929097, Gamma-Secretase Inhibitor RO4929097, RO4929097 γ-secretase inhibitor), 10mM (in 1mL DMSO), CAS: 847925-91-1.
RO4929097 (CAS 847925-91-1) is a potent selective small-molecule inhibitor of -secretase an essential protease in the Notch signaling pathway It inhibits -secretase with high specificity (IC50 4 nM EC50 5 nM) showing minimal inhibitory activity against closely related proteases and over 100-fold selectivity versus a broad spectrum of other proteases By preventing Notch receptor cleavage and subsequent signaling activation RO4929097 suppresses proliferation and tumorigenesis across various tumor models including melanoma breast colorectal pancreatic and lung cancers Clinical studies have assessed RO4929097 alone or combined with other anticancer agents for advanced solid tumors
Apexbio Technology LLC AICAR 10mM (in 1mL DMSO)
A8184 is a small molecule developed primarily as a biomedical research tool It functions through modulation of specific cellular signaling pathways implicated in disease states enabling researchers to probe biological targets and cellular mechanisms By influencing these pathways A8184 provides a methodological approach for dissecting cellular responses and clarifying mechanisms involved in pathological conditions This compound is suited for controlled in vitro studies aimed at elucidating disease pathways and evaluating potential therapeutic avenues in biomedical research contexts
Medchemexpress LLC Benzyl alcohol-d5 (Benzenemethanol-d5) | 68661-10-9 | 99.1% | 50 MG
Benzyl alcohol-d5 is the deuterium-labeled version of Benzyl alcohol. Benzyl alcohol is an aromatic alcohol, characterized as a colorless liquid with a mild, pleasant aromatic odor. It is intended for research use only and not for patient use.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Diuron-d6 | 1007536-67-5 | 99.5% | 1 MG
Diuron-d6 is a deuterium-labeled form of Diuron, an orally active phenylurea herbicide. It functions by inhibiting photosynthesis in plants, specifically by blocking the formation of ATP and NADH. Diuron-d6 also increases the production of Reactive Oxygen Species (ROS) and the expression of p53 in certain cell lines, and has shown herbicidal activity against various broadleaf and grass weeds. It has been noted to promote bladder cancer in some studies and is applicable in breast cancer research.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Verteporfin 129497-78-5 10mM (in 1mL DMSO)
Verteporfin (CAS 129497-78-5) is a porphyrin-derived small molecule used as a photosensitizer in photodynamic therapy (PDT) Upon photoactivation verteporfin induces targeted vascular endothelial cytotoxicity through intravascular damage and thrombosis formation leading to selective vessel closure Experimental studies indicate verteporfin treatment triggers DNA fragmentation and enhances apoptotic events in vitro displaying potent cytotoxicity against HL-60 cells at concentrations around 100 ng/mL Independently of photoactivation verteporfin also directly modifies and inhibits the autophagy adaptor protein p62 impacting its binding to polyubiquitinated substrates Verteporfin is relevant to biomedical research involving PDT mechanisms autophagy pathways and angiogenesis
Medchemexpress LLC 7-keto-Deoxycholic acid | 911-40-0 | 99.7% | 406.56 | 1 ML
7-keto-Deoxycholic acid is a metabolite of bile acids, naturally found in *Clostridium absonum* and convertible by *Lactobacillus* and *Bifidobacterium*. It plays a role in the metabolism of cholic acid and its bioconversion rate increases with the presence of deoxycholic acid. This compound is for research use only.
- Metabolite of bile acids
- Convertible by *Lactobacillus* and *Bifidobacterium*
- Exhibits increased bioconversion rate with deoxycholic acid
- Suitable for research applications
- Solid storage at 4°C, protected from light
- Solution storage at -80°C for 6 months, or -20°C for 1 month, protected from light
Medchemexpress LLC Amlodipine-d4 | 1185246-14-3 | 98.5% | 5 MG
Amlodipine-d4 is a deuterium labeled Amlodipine. Amlodipine is an antianginal agent and an orally active dihydropyridine calcium channel blocker. It functions by blocking voltage-dependent L-type calcium channels, which inhibits the initial influx of calcium. Amlodipine can be utilized for the research of high blood pressure and cancer.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Tiopronin-d3 | 1189700-74-0 | 99.4% | 1 MG
Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin acts as a diffusible antioxidant, an antidote to heavy metal poisoning, and a radioprotective agent. It can regulate the rate of cystine precipitation and excretion, showing potential for treating cystinuria, rheumatoid arthritis, and hepatic disorders. For research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Oxolinic acid-d5 | 1189890-98-9 | 98.0% | 1 MG
Oxolinic acid-d5 is the deuterium-labeled form of Oxolinic acid, an antibiotic effective against both Gram-negative and Gram-positive bacteria. It is used in research for acute and chronic urinary tract infections. This compound functions as a DNA/RNA synthesis inhibitor and a dopamine uptake inhibitor, stimulating locomotor effects in mice. It is intended for research use only.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Effective against Gram-negative and Gram-positive bacteria
- Inhibits DNA/RNA synthesis
- Acts as a dopamine uptake inhibitor
- Stimulates locomotor effects in mice