Solvents
Apexbio Technology LLC Halcinonide 3093-35-4 10mM (in 1mL DMSO)
Halcinonide (CAS 3093-35-4) is a potent synthetic corticosteroid widely utilized in biomedical research as a topical anti-inflammatory agent Mechanistically halcinonide exerts biological effects primarily through activation of glucocorticoid receptor pathways subsequently modulating gene transcription and suppressing the release of inflammatory mediators Owing to its robust corticosteroid receptor agonism and pronounced anti-inflammatory properties this compound frequently supports investigations into inflammatory dermatological conditions and glucocorticoid signaling pathways
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Apexbio Technology LLC Everolimus (RAD001) 159351-69-6 10mM (in 1mL DMSO)
Everolimus (RAD001) is an orally bioavailable small-molecule inhibitor targeting mammalian target of rapamycin (mTOR) an integral serine/threonine kinase regulating cell proliferation metabolism and survival within the PI3K/Akt pathway Everolimus binds intracellularly to the immunophilin FKBP12 the resulting complex subsequently interacts directly with mTOR inhibiting its kinase activity thereby reducing downstream phosphorylation of S6 kinase 1 (S6K1) and the eukaryotic initiation factor 4E-binding protein (4EBP) Functionally Everolimus exerts immunosuppressive properties used clinically to prevent organ transplant rejection and demonstrates antitumor activity against several malignancies including renal cell carcinoma and basal cell carcinoma Commonly utilized in cancer research Everolimus inhibits mTOR with IC50 values reported in the low nanomolar range ( 1 3 nM)
Cayman Chemical L-MethIonIn SulfoxIde 5g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Calcipotriol 112965-21-6 10mM (in 1mL DMSO)
Calcipotriol is a synthetic analogue of vitamin D3 known to bind and activate the vitamin D receptor (VDR) Upon binding to VDR Calcipotriol modulates gene transcription involved in cellular differentiation and proliferation pathways This compound demonstrates regulatory effects on immune cells particularly T cells implicated in psoriasis pathogenesis and induces apoptosis in keratinocytes isolated from psoriasis lesions Calcipotriol also triggers autophagic processes in keratinocytes and HeLa cells in vitro Additionally it suppresses proliferation of various human tumor cell lines including HL-60 and MCF-7 in a concentration-dependent manner In research settings Calcipotriol is used to study differentiation proliferation and inflammatory responses of keratinocytes and immune-related cell types
Apexbio Technology LLC Y-27632 146986-50-7 10mM (in 1mL DMSO)
Y-27632 (CAS 146986-50-7) is a selective inhibitor of Rho-associated protein kinases (ROCK) specifically targeting ROCK1 and ROCK2 isoforms It competitively binds to the ATP-binding site inhibiting ROCK1 and ROCK2 with Ki values of 0 22 M and 0 30 M respectively Compared to other kinases such as citron kinase PKN and PKC Y-27632 exhibits significantly higher selectivity toward ROCK isoforms In cellular assays Y-27632 at 10 M concentration effectively disrupts stress fiber formation in Swiss 3T3 fibroblast cells It is widely used in cell biology research to study ROCK signaling pathways and cytoskeletal dynamics
Apexbio Technology LLC Carbadox 6804-07-5 10mM (in 1mL DMSO)
Carbadox is an antibiotic compound employed in bacterial infection research primarily targeting pathogenic organisms associated with gastrointestinal infections in swine including swine dysentery Its antibacterial mechanism involves inhibition of bacterial DNA synthesis and disruption of nucleic acid metabolism thereby interfering with pathogen replication Carbadox is frequently utilized in microbiology studies investigating therapeutic interventions against enteric bacterial pathogens under controlled laboratory conditions In vitro studies report Carbadox demonstrating bacteriostatic activity with IC50 values typically ranging between 0 5 2 g/mL for common susceptible bacterial strains serving as a reference substance in microbial sensitivity assays
Apexbio Technology LLC MHY1485 326914-06-1 10mM (in 1mL DMSO)
MHY1485 (CAS 326914-06-1) is a potent activator of mammalian target of rapamycin (mTOR) a serine/threonine kinase critical for cellular growth metabolism and survival pathways By activating mTOR signaling MHY1485 inhibits autophagy initiation and disrupts the fusion step between autophagosomes and lysosomes resulting in accumulation of autophagic marker LC3-II and enlarged autophagic structures In cultured rat Ac2F hepatic cells MHY1485 suppresses basal and starvation-induced autophagic flux Additionally MHY1485 treatment promotes ovarian follicular development and increases explant growth in mouse ovarian culture models providing a useful tool in biomedical research of mTOR signaling and reproductive biology
Apexbio Technology LLC RO4929097(Synonyms: RO-4929097, RO 4929097, Gamma-Secretase Inhibitor RO4929097, RO4929097 γ-secretase inhibitor), 10mM (in 1mL DMSO), CAS: 847925-91-1.
RO4929097 (CAS 847925-91-1) is a potent selective small-molecule inhibitor of -secretase an essential protease in the Notch signaling pathway It inhibits -secretase with high specificity (IC50 4 nM EC50 5 nM) showing minimal inhibitory activity against closely related proteases and over 100-fold selectivity versus a broad spectrum of other proteases By preventing Notch receptor cleavage and subsequent signaling activation RO4929097 suppresses proliferation and tumorigenesis across various tumor models including melanoma breast colorectal pancreatic and lung cancers Clinical studies have assessed RO4929097 alone or combined with other anticancer agents for advanced solid tumors
Apexbio Technology LLC VER 155008 1134156-31-2 10mM (in 1mL DMSO)
VER 155008 (CAS 1134156-31-2) is a small molecule inhibitor targeting members of the heat shock protein 70 (Hsp70) chaperone family It primarily inhibits Hsp70 by binding within its ATPase domain and suppressing its intrinsic ATPase activity thereby reducing chaperone-mediated cell survival functions VER 155008 demonstrates potent inhibition of Hsp70 (IC50 0 5 M) and exhibits moderate inhibitory action against related chaperones Hsc70 and glucose-regulated protein Grp78 In cancer cell models this compound diminishes cell proliferation and promotes apoptosis suggesting utility as a research tool in studying chaperone-dependent tumor cell survival pathways
Apexbio Technology LLC Penciclovir 39809-25-1 10mM (in 1mL DMSO)
Penciclovir is a selective inhibitor of herpes simplex virus 1 (HSV-1) DNA synthesis Structurally derived from guanine penciclovir undergoes phosphorylation within virus-infected cells forming penciclovir triphosphate the active antiviral metabolite Penciclovir triphosphate specifically targets viral DNA polymerase blocking HSV-1 DNA replication In vitro experiments using MRC-5 cells demonstrate inhibition of HSV-1 replication at an IC50 of 0 16 M without interfering with host cellular DNA synthesis This mechanism of action renders penciclovir suitable for antiviral research targeting HSV-1 replication as well as drug-resistance and mechanism-of-action studies involving HSV-2 and varicella-zoster virus (VZV)
Apexbio Technology LLC Pepstatin A 26305-03-3 10mM (in 1mL DMSO)
Pepstatin A is a pentapeptide functioning as an inhibitor targeting aspartic proteases including pepsin renin HIV protease and cathepsin D It inhibits human renin and HIV protease with IC50 values of approximately 15 M and 2 M respectively and shows inhibitory activity toward pepsin and cathepsin D at IC50 values below 5 M and 40 M Mechanistically Pepstatin A acts through binding to the catalytic site of aspartic proteases restricting proteolytic activity In biomedical research it is utilized to study viral protein processing osteoclast differentiation mediated by cathepsins and as a standard tool in enzyme inhibition assays examining aspartic protease function
Apexbio Technology LLC A939572 1032229-33-6 10mM (in 1mL DMSO)
A939572 (CAS 1032229-33-6) is an orally bioavailable small-molecule inhibitor targeting stearoyl-CoA desaturase 1 (SCD1) an enzyme that catalyzes the formation of monounsaturated fatty acids involved in lipid metabolism and body weight regulation A939572 selectively inhibits human and mouse SCD1 with IC50 values of 37 nM and 4 nM respectively exhibiting no inhibitory effect on associated cofactors cytochrome b5 or cytochrome b5 reductase By specifically interacting with SCD1 A939572 serves as a pharmacological tool in metabolic research particularly in studies focused on obesity and diabetes
Apexbio Technology LLC Simvastatin (Zocor) 79902-63-9 10mM (in 1mL DMSO)
Simvastatin (CAS 79902-63-9) marketed as Zocor is a synthetic lactone derived from fermented Aspergillus terreus metabolites Following oral administration the inactive lactone is hydrolyzed into an active -hydroxy acid metabolite which specifically inhibits HMG-CoA reductase the rate-limiting enzyme in cholesterol biosynthesis Simvastatin demonstrates antiproliferative effects in hepatocellular carcinoma cells (HepG2 Huh7) inducing apoptosis cell cycle arrest at G0/G1 reducing expression of cyclins (D1 E) and cyclin-dependent kinases (CDK1 2 4) while elevating CDK inhibitors p19 and p27 It is therefore utilized extensively for research in cancer biology cardiovascular pathology and lipid metabolism disorders