Glycosyl compounds
Apexbio Technology LLC Anti-Amyloid-Beta-Ab-Donanemab
Anti-Amyloid Beta Antibody (Donanemab) (CAS No 1931944-80-7) is a monoclonal antibody under investigation in the field of neurodegenerative research specifically for Alzheimer s disease Originating from biotechnology developments its primary mechanism involves targeting amyloid beta plaques which are believed to contribute to Alzheimer s pathology It binds to a specific epitope on deposited amyloid plaques promoting clearance and reducing their accumulation Common in vitro activity has been observed in the nanomolar to low micromolar range Typical applications include use in cell models animal studies and drug screening assays to assess efficacy and mechanistic pathways Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC Anti-Amyloid Beta Solanezumab
Anti-Amyloid Beta Antibody (Solanezumab) (CAS No 955085-14-0) is a monoclonal antibody used in Alzheimer s research originating from Eli Lilly and Company It specifically targets amyloid beta plaques implicated in Alzheimer s pathogenesis by binding to soluble monomers thereby reducing plaque formation Solanezumab s action is primarily observed in the modulation of amyloid beta clearance mechanisms within the central nervous system In vitro activity typically occurs in the nanomolar range reflecting its high affinity and specificity for amyloid beta peptides It s commonly applied in cell models and animal studies to evaluate therapeutic potential particularly in transgenic mice expressing human amyloid precursor protein Additionally Solanezumab is prominent in drug screening processes for Alzheimer s therapeutics Experimental concentrations typically depend on the specific research design ensuring flexibility in dose-response assessments across different methodologies
Medchemexpress LLC m-PEG7-4-nitrophenyl carbonate | 678150-56-6 | >97.1% | C20H31NO11 | 2 MG
m-PEG7-4-nitrophenyl carbonate is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for selective degradation of target proteins. It appears as a colorless to light yellow liquid and is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Colorless to light yellow liquid appearance
- For research use only
Medchemexpress LLC 4-Nitrophenyl α-L-rhamnopyranoside | 18918-31-5 | >99.8% | 285.25 | 25 MG
4-Nitrophenyl α-L-rhamnopyranoside is a commonly used substrate in various biochemical assays to measure the activity of enzymes that hydrolyze rhamnose, such as α-L-rhamnosidase. It has unique chemical properties that allow it to be hydrolyzed by these enzymes to form a yellow product called p-nitrophenol. This makes it a useful tool for detecting and quantifying rhamnohydrolase activity in biological samples or microbial cultures.
- Used as a substrate in biochemical assays to measure α-L-rhamnosidase activity.
- Hydrolyzed to form a yellow product, p-nitrophenol, for detection and quantification.
- Useful for detecting and quantifying rhamnohydrolase activity in biological samples or microbial cultures.
- In vitro, it serves as a rhamnose-α substrate for rhamnosidase.
Sigma Aldrich Fine Chemicals Biosciences Amyloid beta Protein fragm1MG
Amyloid Protein fragment 1-40 (A40) is derived from the amyloid- protein (A) which is mapped to human chromosome 21q21.3. A40 is predominantly present in the vascular amyloid deposits. A40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a helical structure in a water-micelle medium.
Cayman Chemical 4-MethylumbelIferylD-Gala 5g
A fluorogenic substrate for β-galactosidase; hydrolysis of MUG by β-gal releases the fluorescent moiety 4-MU, which displays a pH-dependent excitation maximum of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm; has been used to detect β-gal activity in intact bacteria, yeast, and mammalian cells
Sigma Aldrich Fine Chemicals Biosciences Carminic acid | 1260-17-9 | MFCD00167028 | 1G
Carminic acid | Purity: >=90% (HPLC) | Mol Wt: 492.39 | 1260-17-9 | MFCD00167028 | 1G
Medchemexpress LLC Tricin 7-O-glucuronide | 32769-02-1 | 99.1% | 506.41 | 10 MG
Tricin 7-O-glucuronide is an Alfalfa (Medicago sativa L.) flavonoid that can be obtained from the leaves of M. tenuifollium G. Forster. It is for research use only.
- Solid, light yellow to yellow appearance
- Molecular formula: C23H22O13
- Classified as a flavonoid, flavone, phenol, and polyphenol
- Initial source is plants, specifically Medicago sativa L.
- Solubility in DMSO: ≥ 100 mg/mL
- Store at 4°C, protected from light, under nitrogen
Medchemexpress LLC Rhein 8-O-β-D-Glucopyranoside | 34298-86-7 | 1 ML
Rhein 8-O-β-D-Glucopyranoside is an anthraquinone glycoside isolated from rhubarb, known for its purgative activity. This compound exhibits high purity at 99.81% and appears as a light yellow to yellow solid. It is soluble in DMSO and can be prepared in various in vivo dissolution protocols.
- Anthraquinone glycoside
- Isolated from rhubarb
- Exhibits purgative activity
- Purity of 99.81%
- Appearance as a light yellow to yellow solid
- Molecular formula C21H18O11
- Molecular weight 446.36
![eMolecules 7693-46-1 | 4-Nitrophenyl chloroformate | Key Organics/BIONET - Building Blocks | MFCD00007321 | 201.560 | C7H4ClNO4 | 95.000 | [O-][N+](=O)c1ccc(OC(Cl)=O)cc1 | 1mg | 344513580](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000129288.jpg-250.jpg)
eMolecules 7693-46-1 | 4-Nitrophenyl chloroformate | Key Organics/BIONET - Building Blocks | MFCD00007321 | 201.560 | C7H4ClNO4 | 95.000 | [O-][N+](=O)c1ccc(OC(Cl)=O)cc1 | 1mg | 344513580
4-Nitrophenyl chloroformate | Key Organics/BIONET - Building Blocks | 7693-46-1 | MFCD00007321 | 201.560 | C7H4ClNO4 | 95.000 | [O-][N+](=O)c1ccc(OC(Cl)=O)cc1 | 1mg | 344513580
Research Products International Corp p-Nitrophenyl-B-D-galactopyranoside, 5 G
Colorimetric and spectrophotoametric substrate for detection of B-D Galactosidase.
Sigma Aldrich Fine Chemicals Biosciences beta Lactoglobulin from bo5G
Milk from dairy cows contains the protein -lactoglobulin (BLG). It naturally occurs in a number of genetic variants and the most prevalent bovine variants are BLG A and BLG B.
Medchemexpress LLC NRG1-beta 1 Human 20ug
NRG1-beta 1 Protein Human (HEK293) is the recombinant human-derived NRG1-beta 1 protein expressed by HEK293 with tag free
Selleck Chemical LLC Anti-Amyloid Beta-A2813-1MG
Anti-Amyloid Beta is a recombinant monoclonal antibody in a single chain fragment variable (scFv) against amyloid beta has the potential to be used in Alzheimer s disease (AD) research MW 145 14 KD