Steroids and derivatives
Medchemexpress LLC 3-epi-Vitamin D3 (Epicholecalciferol) | 57651-82-8 | C27H44O | 100 MG
3-epi-Vitamin D3 (Epicholecalciferol) is a Vitamin D3 analogue that acts as a Hedgehog pathway inhibitor. It has demonstrated antiproliferative activity in human U87MG cells with an IC50 of 39.2 μM. This compound is intended for research use only.
- Hedgehog pathway inhibitor
- Exhibits antiproliferative activity against U87MG cells
- Significantly upregulates Cyp24A1 in various cell lines
Cayman Chemical HeptadecnoIc AcId-d3 10mg
An internal standard for the quantification of heptadecanoicacid by GC- or LC-MS
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Medchemexpress LLC Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 50 MG
Estrone sulfate potassium is an inactive endogenous estrogen, convertible to Estrone and Estradiol, and a substrate of the OATP1B3 transporter. It stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, making it applicable to breast cancer-related research.
- Inactive endogenous estrogen
- Can be converted into Estrone and Estradiol
- Substrate of the OATP1B3 transporter
- Stimulates growth of mammary tumors in ovariectomized rats
- Promotes colony formation of dispersed mammary cells
- Useful for breast cancer-related research
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Eldecalcitol | 104121-92-8 | 99.9% | C30H50O5 | 5 MG
Eldecalcitol (ED-71) is an orally active vitamin D3 analogue that inhibits bone resorption and increases bone mineral density. It also exhibits an anti-tumor effect, inhibits cell proliferation, migration, and induces apoptosis by suppressing GPx-1.
- Orally active vitamin D3 analogue
- Inhibits bone resorption and increases bone mineral density
- Exhibits anti-tumor effects
- Inhibits cell proliferation and migration
- Induces apoptosis by suppressing GPx-1
- Shows no cytotoxicity at 0-50 nM for 24 hours
- Reduces cell death induced by LPS
- Inhibits LPS-induced pyroptosis by activating Nrf2 and its effector molecule HO-1
- Arrests cell cycle at G0/G1 phase
- Stimulates focal bone formation and suppresses bone resorption
Medchemexpress LLC 3(2H)-Pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-d3 | 99.4% | 25 MG
Pimobendan-d3 (UD-CG115-d3) is a deuterium labeled form of Pimobendan, a selective inhibitor of PDE3. It is intended for research use only, not for patient use. Deuterium labeled compounds like Pimobendan-d3 are used as tracers in quantitation during drug development, with deuteration potentially affecting pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Selleck Chemical LLC Estradiol S1709-1g
Estradiol (17 -estradiol -Estradiol E2 17 -Oestradiol) is a human sex hormone and steroid and the primary female sex hormone Estradiol upregulates IL-6 expression through the estrogen receptor (ER ) pathway
Medchemexpress LLC Bazedoxifene (acetate) | 198481-33-3 | 99.88% | C32H38N2O5 | 500 MG
Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM). It has IC50s of 23 nM for ERα and 99 nM for ERβ. This compound is used in the research of osteoporosis. Additionally, Bazedoxifene acetate acts as an inhibitor of IL-6/GP130 protein-protein interactions and is utilized in research for pancreatic cancer.
- Oral, nonsteroidal selective estrogen receptor modulator (SERM)
- Exhibits IC50s of 23 nM for ERα and 99 nM for ERβ
- Used in osteoporosis and pancreatic cancer research
- Inhibits IL-6/GP130 protein-protein interactions and STAT3 phosphorylation
- Induces apoptosis and blocks cell migration in pancreatic cancer cells in vitro
- Inhibits Capan-1 tumor growth in a mouse model in vivo
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 100 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol. This compound is a white to off-white solid with a purity of 98.8%. It is suitable for research applications.
- Synthetic derivative of estradiol
- Purity of 98.8%
- Molecular weight of 372.45
- White to off-white solid appearance
- Store at 4°C under nitrogen
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO
Selleck Chemical LLC Dexamethasone palmitate S5184-5mg
Dexamethasone palmitate (DXP) a lipophilic prodrug of Dexamethasone (DXM) is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM Dexamethasone palmitate (DXP) exhibits anti-inflammatory activity
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 5 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase.
- Used for research purposes.
Medchemexpress LLC Ciraparantag acetate | 1644388-83-9 | 98.0% | 873.01 | 5 MG
Ciraparantag acetate (PER977) is a thrombin and factor Xa inhibitor that functions as a broad-spectrum reversal agent for anticoagulants, including low molecular weight heparins, unfractionated heparins, and some direct oral anticoagulants. It does not reverse Vitamin K antagonists (VKAs).
- Small, synthetic, and cationic molecule
- Binds to direct Factor Xa inhibitors and direct thrombin inhibitors
- Binds to unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge-charge interactions
- Shows reversal of anticoagulants in rat-tail transection bleeding assays
- Reduces bleeding as observed in thromboelastography studies
- Soluble in H2O at 125 mg/mL (requires ultrasonic treatment)
Cayman Chemical 25-hydroxy VItamIn D2 500ug
A metabolite of vitamin D2; serum levels of 25-hydroxy vitamin D2 have been used as a marker of vitamin D status