Steroids and derivatives
Cayman Chemical EstradIol CypIonate 1g
A synthetic estrogen; reduces estrogen-depletion induced spikes in basal tail temperature in ovariectomized wild-type, ERα-/-, and ERβ-/- mice at 0.1 mg/kg per day; increases the rate of pregnancy in cows induced to ovulate small dominant follicles; reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | 99.9% | 1 ML
Estradiol (β-Estradiol) is a steroid hormone and the primary female sex hormone. It can increase the expression of neural markers in human endometrial stem cells (hEnSCs) and promote their neural differentiation. This product is intended for research use only and is utilized in studies concerning cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases expression of neural markers in human endometrial stem cells.
- Promotes neural differentiation of human endometrial stem cells.
- Utilized in research for cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases SIRT1 protein levels in C2C12 cells.
- Increases FoxL2 and pFoxL2 protein expression levels in ZF4 cells.
- Promotes proliferation of sheep myoblasts.
- Enhances expression of ERRα and VLDL-related genes in primary hepatocytes.
- Induces mRNA expression of pS2 and NRF1 genes in MCF-7 cells.
Gold Biotechnology Inc Digitonin Special Grade
Digitonin is a nonionic saponin steroid derived from the plant Digitalis purpurea It is useful for creating Digitonin-cholesterol complexes which form when Digitonin disrupts the cell membrane and binds with cholesterol in a nearly 1 1 stoichiometric ratio When precipitated from ethanolic solutions these complexes form flat lamellar sheets Digitonin s cholesterol displacing properties have been used in newer applications to quantify the rate of lysosomal membrane permeabilization (LMP) a new technique developed to bypass traditional cell death pathways Digitonin permeabilizes plasma membranes but leaves lysosomal membranes intact allowing for a quantifiable measurement of lysosomal hydrolases and comparison to normal cellular enzyme activity Digitonin has been shown to induce hemolysis in red blood cells
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 10 MG
Estradiol 3-methyl ether is a synthetic estrogen that can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibit cell proliferation. Additionally, it decreases serum cholesterol levels and increases body weight loss, showing feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss
- Useful for biochemical assays
- Potential for research into microtubule modulation and cell proliferation
- Applicable in studies related to cholesterol regulation and weight management in relevant models
Medchemexpress LLC Estradiol dipropionate | 113-38-2 | 99.5% | 50 MG
Estradiol dipropionate is a combined estrogen-progesterone that acts as an estrogen and progesterone agonist. It is for research use only and not sold to patients.
- Acts as an estrogen and progesterone agonist.
- Suitable for in vivo studies.
- Used in research for metabolic or endocrine disease.
Sigma Aldrich Fine Chemicals Biosciences beta-Estradiol 6-O-carboxy5MG
BETA beta-Estradiol 6-O-carboxy5MG
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | 98.6% | 5 MG
Estradiol-d3 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. This compound serves as a tracer and internal standard for quantitative analysis, leveraging the potential of deuteration to influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration influences drug pharmacokinetic and metabolic profiles
- Appears as a white to off-white solid
- Molecular weight: 275.40
- Chemical formula: C18H21D3O2
- Powder storage: -20°C for 3 years or 4°C for 2 years
- Solvent storage: -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (50 mg/mL) and ethanol (20 mg/mL)
Medchemexpress LLC Estradiol 3-glucuronide sodium | 14982-12-8 | 1 MG
Estradiol 3-glucuronide sodium is an estrogen metabolite, a glucuronide conjugate formed in tissues like the liver from Estradiol. It is a potent substrate of Mrp2, achieving hepatobiliary transport in hepatocytes via basolateral uptake through OATP1B1, OATP1B3, and OATP2B1, and apical efflux via MRP2 and BCRP. For research use only.
- Substrate for OATP1B1, OATP1B3, and OATP2B1 in HEK293T cells.
- Uptake inhibited by OATP substrates and inhibitors.
- Inhibits OATP1B3- and OATP2B1-mediated estrone-3-sulfate uptake.
- Inhibits OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin uptake.
- Substrate of rat Mrp2 in Sf9 cell membrane vesicles.
- Competitively inhibits rat Mrp2-mediated Estradiol 17-glucuronide transport.
- Used to produce high-affinity antiserum for radioimmunoassay in urine samples.
Sigma Aldrich Fine Chemicals Biosciences Estradiol hemihydrate European Pharmacopoeia (EP) Reference Standard | 35380-71-3 | MFCD23102821 |
Estradiol hemihydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 281.39 | 35380-71-3 | MFCD23102821 |
Cayman Chemical 17-EstradIol-d3 10mg
An internal standard for the quantification of 17β-estradiol by GC- or LC-MS
Selleck Chemical LLC Ethinyl Estradiol S1625-1g
Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills
Selleck Chemical LLC Alpha-Estradiol
Alpha-Estradiol ( -Estradiol 17 alpha-Estradiol Alfatradiol Epiestradiol Epiestrol Alora 17 -E2) a natural non-feminizing stereoisomer a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 -E2) is a weak inhibitor of estrogen
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 100mg
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Medchemexpress LLC Estradiol-d4 | 66789-03-5 | 99.1% | 1 ML
Estradiol-d4 | 66789-03-5 | 99.1% | 1 ML