Purine nucleotides
Medchemexpress LLC Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 5 G
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. It demonstrates significant antiviral activity against HSV-1 and HSV-2. In vitro studies show that its cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells.
- Negligible cell toxicity at 25 to 400 μM in RAW264.7 cells
- Attenuates mRNA expression of TNF-α and IL-6 in RAW264.7 cells
- Reduces NF-κB p65 recruitment to TNF-α, IL-6, and IL-1β gene promoters
- Increases hepatic adenosine levels and improves survival rates in mice
- Lowers serum AST and ALT levels, reduces liver necrosis and inflammatory cell infiltration
Apexbio Technology LLC 2'-O-Methyl-2-Amino-ATP 10ul (100 mM)
2p-O-Methyl-2-Amino-ATP is a modified nucleoside triphosphate incorporating methylation at the ribose 2 -hydroxyl group and an amino substitution at the 2 position of the adenine base It is designed to alter nucleotide biochemical properties impacting RNA stability and structure upon enzymatic incorporation In in vitro transcription assays 2p-O-Methyl-2-Amino-ATP demonstrates an ability to increase RNA resistance to exonuclease-mediated degradation and induce altered RNA secondary structures Based on these properties 2p-O-Methyl-2-Amino-ATP holds research potential in studies of RNA folding dynamics stability assays RNA-protein interactions and analyses involving chemically modified RNA in biomedical research
Medchemexpress LLC Mtb ATP synthase-IN-1 | 2642394-38-3 | 98.6% | C17H13N3O4 | 10MG
Mtb ATP synthase-IN-1 is a potent Mycobacterium tuberculosis ATP synthase inhibitor (compound 6ab) for anti-mycobacterial research. It exhibits MIC 0.452-0.499 μg/mL against M. tuberculosis, demonstrates good metabolic stability and acceptable oral bioavailability, and shows low cytotoxicity in Vero cells.
- Potent inhibition of M. tuberculosis ATP synthase
- MIC 0.452-0.499 μg/mL against M. tuberculosis
- Good metabolic stability
- Low cytotoxicity (Vero IC50 > 64 μg/mL)
- High purity (~98.6%)
- Available in multiple solid and solution pack sizes
- Stable storage recommendations for powder and solutions
Medchemexpress LLC L-adenosine | 3080-29-3 | MFCD01075784 | 99.8% | 267.25 g/mol | C10H13N5O4 | 25 MG
L-adenosine is a high-purity adenosine deaminase (ADA) inhibitor provided as a powdered research reagent for in vitro biochemical and cellular studies. The 25 mg vial is suitable for assay development, enzymatic assays, and dose-response experiments, with documented solubility and recommended storage conditions to preserve stability.
- High purity (99.82%).
- Suitable for in vitro biochemical and cellular assays.
- Powdered solid supplied as a 25 mg vial for small-scale studies.
- Soluble in DMSO (~8.33 mg/mL) with ultrasonic assistance; hygroscopic solvent may affect solubility.
- Store at 4°C protected from light; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Adenosine 5'-triphosphate-13C10,15N5 dilithium | 56-65-5 | 13C10H14Li215N5O13P3 | 1 MG
Adenosine 5'-triphosphate-13C10,15N5 dilithium is a 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate. It is a central component of energy storage and metabolism in vivo, providing metabolic energy for pumps and serving as a coenzyme in cells. It also functions as an important endogenous signaling molecule in immunity and inflammation.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Provides metabolic energy to drive metabolic pumps
- Serves as a coenzyme in cells
- Acts as an endogenous signaling molecule in immunity and inflammation
Medchemexpress LLC Cytarabine triphosph 10mg | 1179343-17-9 | 549.10 | C9H13N3Na3O14P3 | 10 MG
Cytarabine triphosphate trisodium is the trisodium salt of the active intracellular metabolite of cytarabine, provided as an aqueous solution for biochemical and cell biology research. It acts as a competitive inhibitor of DNA synthesis and is used to study nucleoside metabolism and antimetabolite mechanisms.
- Active intracellular metabolite of cytarabine (Ara-CTP).
- Competitive inhibitor of DNA synthesis.
- Supplied as an aqueous solution at 100 mM; common pack sizes include 5 mg, 10 mg, 25 mg, and 50 mg.
- Purity: 96.78%.
- Appearance: colorless to light yellow liquid.
- Salt form: trisodium; molecular weight 549.10; formula C9H13N3Na3O14P3.
- Storage: store at -20°C for long-term; stock solutions at -80°C (up to 6 months) or -20°C (1 month).