Purine nucleotides
Medchemexpress LLC Inosine 5'-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 25 MG
Inosine 5′-diphosphate sodium is a purine ribonucleoside 5′-diphosphate with inosine as the nucleobase. It can participate in intracellular energy metabolism and signal transduction processes. This product is for research use only.
- Purine ribonucleoside
- Involved in intracellular energy metabolism
- Participates in signal transduction processes
- Useful for research in respiratory and metabolic diseases
- Classified as a nucleotide analog and endogenous metabolite
Medchemexpress LLC Adenosine 5'-O-(2-thiodiphosphate) trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | C10H12Li3N5O9P2S | 10MG
ADP-β-S trilithium is the trilithium salt of adenosine 5'-β-thiodiphosphate, used in research as a P2Y12 receptor activator. It is supplied as a white to off-white solid (CAS 73536-95-5) with listed purity ~94.9% and molecular formula C10H12Li3N5O9P2S. Store sealed and away from moisture; in solution store at -80°C for long-term stability.
- Activator of P2Y12 receptor in cellular assays.
- Upregulates IL-1β and IL-6 production in microglial models.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation in relevant studies.
- Provided as a solid suitable for preparation of assay solutions.
- Stable under recommended sealed, low-temperature storage conditions.
Cayman Chemical Adenosine 5'-monophosphate (sodium salt hydrate), Purity: ≥95%, CAS: 149022-20-8, 1 g
A central nucleotide with functions in metabolism and cell signaling
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.4% | C9H14N5Na2O10P3 | 10MG
Tenofovir diphosphate disodium is the disodium salt of the active intracellular metabolite of tenofovir. It functions as an antiretroviral nucleotide analog and inhibitor of HIV-1 reverse transcriptase, and is provided for in vitro research into viral replication and polymerase activity. The compound is supplied as a solid for laboratory use.
- High purity (99.4%).
- Disodium salt form improves aqueous compatibility.
- Inhibits HIV-1 reverse transcriptase for biochemical assays.
- Available in small research pack sizes for laboratory experiments.
- Solid, white to off-white appearance for easy handling.
- Intended for research use only, not for human consumption.
Medchemexpress LLC Adenosine 5'-β-thiodiphosphate trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | 461.07 g·mol⁻¹ | C10H12Li3N5O9P2S | 5 MG
ADP-β-S trilithium is the trilithium salt form of adenosine 5'-β-thiodiphosphate used as a research reagent to activate P2Y12 receptors and study purinergic signaling and inflammatory pathways. It modulates cytokine production and NF-κB/NLRP3 signaling, and is provided as a dry powder for laboratory use.
- Activates P2Y12 receptor to modulate purinergic signaling.
- Increases IL-1β and IL-6 production in microglial cells.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation.
- Supplied with stated purity and molecular data for experimental planning.
- Suitable for biochemical and cellular assays requiring receptor activation.
Medchemexpress LLC Uridine 5'-(trihydrogen diphosphate), 4-oxime | 39023-73-9 | 98.8% | 419.18 | 10 MG
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in a diphosphate form. NHC is a pyrimidine ribonucleoside and acts as a potent anti-virus agent, effectively inhibiting the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV).
- Active phosphorylated intracellular metabolite
- Potent anti-virus agent
- Inhibits replication of Venezuelan equine encephalitis virus (VEEV)
- Inhibits replication of Chikungunya virus (CHIKV)
- Inhibits replication of hepatitis C virus (HCV)
- For research use only
- Soluble in H2O: 160 mg/mL (needs ultrasonic)
- Store at -20°C, protect from light, stored under nitrogen
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Potassium diphosphate | 7320-34-5 | MFCD00011393 | 1kg
Potassium diphosphate (tetra-Potassium pyrophosphate) is a kind of biological materials or organic compounds that are widely used in life science research[1]
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.42% | 491.14 | 1 MG
Tenofovir diphosphate disodium is an antiretroviral agent primarily used for AIDS research. It acts as an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound exhibits minimal inhibitory effect on eukaryotic DNA replication in vitro.
- Antiretroviral agent
- Inhibits HIV reverse transcriptase DNA and RNA
- Used for AIDS research
- Minimal inhibitory effect on eukaryotic DNA replication in vitro
Medchemexpress LLC Cidofovir diphosphate tri(triethylamine) | 00-00-0 | 99.9% | 742.72 g/mol | C26H61N6O12P3 | 5 MG
Cidofovir diphosphate tri(triethylamine) is the triethylamine salt of cidofovir diphosphate, an active intracellular metabolite and selective inhibitor of viral DNA polymerases. It is provided as a high-purity biochemical reagent intended for in vitro and biochemical research applications.
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Research Products International Corp Coenzyme A Trilithium Salt, 25 MG
Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes.
Medchemexpress LLC Uridine diphosphate glucuronic acid | 2616-64-0 | 98.0% | 580.29 g/mol | C15H22N2O18P2 | 10MG
Uridine diphosphate glucuronic acid (UDP-GlcA) is a sugar nucleotide cofactor used in biochemical and enzymatic research. It participates in glucuronidation and nucleotide sugar metabolism and serves as a substrate for glycosyltransferases and UDP-glucose dehydrogenase assays. The reagent is supplied for research use in biochemical assays and pathway studies.
- High purity (98.0%) for reliable assay performance.
- Molecular weight 580.29 g/mol and formula C15H22N2O18P2 for precise calculations.
- Available in small pack sizes including 10 mg for screening and method development.
- Suitable as a substrate in enzymatic and glycosylation studies.
- Provided with batch-specific COA and SDS for traceability.
Apexbio Technology LLC Chloroquine diphosphate 50-63-5 10mM (in 1mL H2O)
Chloroquine diphosphate is an antimalarial agent and inhibitor of TLR7 and TLR9 commonly used in biomedical research to modulate autophagic processes On the cellular level chloroquine diphosphate promotes autophagy through cell cycle arrest at the G1 phase involving increased expression of p27 and p53 and decreased levels of CDK2 and cyclin D1 Additionally chloroquine diphosphate enhances sensitivity of cancer cells toward chemotherapy and radiotherapy treatments by elevating autophagy and apoptotic responses In vitro studies demonstrated dose-dependent activity with reported IC50 values typically ranging from approximately 15 to 40 M depending on cell types This compound is widely utilized as an autophagy modulator and therapeutic adjuvant in tumor cell models
Sigma Aldrich Fine Chemicals Biosciences Coenzyme A Trilithium Salt | ≥85% Purity | Mol Wt: 767.5 | ®93-18-4-3 | 10 mg
Coenzyme A trilithium salt | Purity: ≥85% | Mol Wt: 767.5 | CAS No: 93-18-4-3 | Biochemical cofactor involved in metabolic pathways and energy production via acyl transfer and thioesterification | 10mg
