Drug Standards
Medchemexpress LLC Ropinirole hydrochloride | 91374-20-8 | 99.9% | 50 MG
Ropinirole hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for the D2 receptor. It exhibits pEC50s of 7.4, 8.4, and 6.8 for hD2, hD3, and hD4 receptors, respectively, and demonstrates no affinity for D1 receptors. This compound is under investigation for its therapeutic potential in treating Parkinson's disease.
- Potent D3/D2 receptor agonist
- Ki of 29 nM for D2 receptor
- pEC50s of 7.4 (hD2), 8.4 (hD3), and 6.8 (hD4)
- No affinity for D1 receptors
- Higher affinity for D3 receptors compared to D2 and D4 receptors
- Weakly active at alpha 2-adrenoceptors and 5-HT2 receptors
- Inactive at 5-HT1, benzodiazepine, gamma-aminobutyric acid receptors, or alpha 1 and beta-adrenoceptors
- Investigated for potential in treating Parkinson's disease
Medchemexpress LLC Naphazoline hydrochloride | 550-99-2 | 99.4% | 10 MM * 1 ML
Naphazoline hydrochloride is a potent α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also decreases the levels of inflammatory factors (TNF-α, IL-1β, and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. This compound can be used for non-bacterial conjunctivitis research and is intended for research use only, not sold to patients.
- Potent α-adrenergic receptor agonist
- Reduces vascular hyperpermeability and promotes vasoconstriction
- Decreases inflammatory factors (TNF-α, IL-1β, and IL-6)
- Decreases cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF
- Suitable for non-bacterial conjunctivitis research
Medchemexpress LLC Isradipine | 75695-93-1 | 5 MG
Isradipine is an orally active, blood-brain barrier permeable L-type calcium channel blocker. It functions as a potent peripheral vasodilator and is a dihydropyridine calcium antagonist with selective effects on the heart and peripheral circulation. Isradipine is considered a potentially viable neuroprotective agent for Parkinson's disease.
- Orally active
- Blood-brain barrier permeable
- L-type calcium channel blocker
- Potent peripheral vasodilator
- Dihydropyridine calcium antagonist with selective effects on the heart and peripheral circulation
- Potentially viable neuroprotective agent for Parkinson's disease
Medchemexpress LLC Ibiglustat (succinate) | 1629063-80-4 | 99.7% | 507.57 | 50 MG
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be utilized for research related to Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
- Orally active.
- Brain-penetrant glucosylceramide synthase (GCS) inhibitor.
- Can be used for research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
Apexbio Technology LLC Alprostadil(Synonyms: Prostaglandin E1, PGE1, Alprostadilum, Edex, Caverject, Muse, Prostin VR, Liprostin), 10mg, CAS: 745-65-3.
Alprostadil (CAS 745-65-3) also known as prostaglandin E1 is an endogenous prostaglandin analog that exerts potent vasodilatory activity by binding and activating prostaglandin E-type (EP) receptors primarily EP2 and EP4 Upon receptor activation intracellular cyclic adenosine monophosphate (cAMP) levels rise mediating smooth muscle relaxation and vasodilation Clinically Alprostadil is investigated and utilized in research contexts addressing vascular biology erectile dysfunction mechanisms and cardiovascular function offering insights into prostaglandin signaling pathways
Medchemexpress LLC Lenalidomide | 191732-72-6 | C13H13N3O3 | 500 MG
Lenalidomide | 191732-72-6 | C13H13N3O3 | 500 MG
Medchemexpress LLC Meloxicam (Standard) | 71125-38-7 | 99.89% | 25 MG
Meloxicam (Standard) is the analytical standard of Meloxicam, a non-steroidal anti-inflammatory agent that inhibits COX activity. It is intended for research and analytical applications, commonly used as a reference standard in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Inhibits COX activity with IC50s of 0.49 μM for COX-2 and 36.6 μM for COX-1.
- Used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Suitable for use in HPLC, GC, and MS.
- Has a molecular weight of 351.40.
- Chemical formula is C14H13N3O4S2.
- Appearance is a solid, light yellow to green yellow in color.
- Purity is 99.89%.
Medchemexpress LLC Voriconazole impurity 1 | 137330-52-0 | ≥98.0% | C16H14F3N5O | 50 MG
Voriconazole impurity 1 is a chemical compound that serves as an impurity of Voriconazole. It has a molecular weight of 349.31 and a chemical formula of C16H14F3N5O. This solid substance has a purity of ≥98.0% and is intended for research use only.
- Suitable for research applications
- Purity of ≥98.0%
- Solid appearance
- Store at 4°C in sealed, moisture-free conditions
- When in solvent, store at -80°C for 6 months or -20°C for 1 month
Apexbio Technology LLC Ciprofloxacin hydrochloride hydrate 86393-32-0 5g
Ciprofloxacin hydrochloride hydrate (CAS 86393-32-0) is a small-molecule inhibitor targeting bacterial DNA topoisomerase IV It is designed to inhibit topoisomerase IV-mediated DNA processes thereby impairing DNA replication and promoting DNA damage Ciprofloxacin hydrochloride hydrate exerts its biological activity primarily through inhibition of bacterial DNA topoisomerase IV leading to disruption of nuclear and mitochondrial DNA integrity mitochondrial dysfunction and increased intracellular reactive oxygen species (ROS) In cellular assays ciprofloxacin hydrochloride hydrate demonstrates inhibitory activity with IC50 values typically ranging between 5 50 M depending on the cell type and experimental conditions Based on these pharmacological properties ciprofloxacin hydrochloride hydrate holds research potential in elucidating fluoroquinolone-induced topoisomerase inhibition apoptotic pathways DNA damage responses and antiproliferative effects
Apexbio Technology LLC Citalopram hydrobromide 59729-32-7 50mg
Citalopram hydrobromide (CAS 59729-32-7) is a selective serotonin reuptake inhibitor (SSRI) that functions by specifically blocking the reuptake of 5-hydroxytryptamine (5-HT) at presynaptic neuronal membranes thereby increasing 5-HT concentrations in the synaptic cleft In vitro studies demonstrate that citalopram hydrobromide exhibits potent nanomolar-level inhibition of 5-HT reuptake in synaptosomal preparations as well as low nanomolar inhibition in rabbit platelet assays This compound is widely utilized in research exploring serotonergic signaling neurotransmission processes and experimental models of depression
Selleck Chemical LLC Idoxuridine S1883-1g
Idoxuridine (NSC 39661 SKF 14287 5-Iodo-2 -deoxyuridine 5-IUdR IdUrd) is an antiviral agent for feline herpesvirus type-1 with IC50 of 4 3 M
Cayman Chemical HexnoIc AcId-d11 1g
An internal standard for the quantification of hexanoic acid by GC- or LC-MS
Medchemexpress LLC Acarbose (standard) | 56180-94-0 | 99.9% | C25H43NO18 | 50 MG
Acarbose (Standard) is an analytical standard of Acarbose, intended for research and analytical applications. This orally active alpha-glucosidase inhibitor (IC50=11 nM) can potentiate the hypoglycemic effects of sulfonylureas or insulin. It is an analytical standard grade suitable for qualitative, quantitative, and methodological research experiments.
- Analytical standard for Acarbose
- Intended for research and analytical applications
- Orally active alpha-glucosidase inhibitor (IC50=11 nM)
- Can potentiate hypoglycemic effects of sulfonylureas or insulin
- Suitable for HPLC, GC, and MS experiments
Medchemexpress LLC Amoxicillin piperazine-2,5-dione | 94659-47-9 | 25mg
Amoxicillin Impurity 7 is an impurity of Amoxicillin (HY-B0467A)
Medchemexpress LLC Octyl gallate | 1034-01-1 | 282.33 | 1 G
Octyl gallate (Progallin O) is extensively utilized as a food additive due to its antimicrobial and antioxidant properties. It exhibits a selective and sensitive fluorescent characteristic and demonstrates a significant antiviral effect against HSV-1, vesicular stomatitis virus (VSV), and poliovirus.
- Food additive
- Antimicrobial activity
- Antioxidant activity
- Selective and sensitive fluorescent property
- Antiviral effect against HSV-1, vesicular stomatitis virus (VSV), and poliovirus