Drug Standards
Medchemexpress LLC Mitotane | 53-19-0 | 320.04 | 1 ML
Mitotane (2,4′-DDD) is an isomer of DDD and a derivative of dichlorodiphenyltrichloroethane (DDT). It acts as an antineoplastic agent primarily used in adrenocortical carcinoma research. Its adrenocorticolytic effect is exerted, in part, through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can also influence corticotroph cells in the pituitary and activate CYP3A4 gene expression via steroid and xenobiotic receptor (SXR).
- Used as an antineoplastic agent in adrenocortical carcinoma research
- Exerts adrenocorticolytic effect through lipotoxicity
- Induces CYP3A4 gene expression via SXR activation
- Can have direct pituitary effects on corticotroph cells
Medchemexpress LLC Fostamatinib disodium hexahydrate | 914295-16-2 | 99.5% | 50 MG
Fostamatinib disodium hexahydrate is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor, also inhibiting Lyn and Lck. This product is for research use only.
- Oral proagent of R406
- Orally available
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn and Lck
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Melatonin, 73-31-4, MFCD00005655, 250 mg
Empirical Formula (Hill Notation): C13H16N2O2, Molecular Weight: 232.28, powder, ≥98% (TLC), mp: 116.5-118 °C, storage temp: −20°C, Synonym: N-Acetyl-5-methoxytryptamine.
Medchemexpress LLC Celecoxib 10Mm 1Ml Dmso Soluti | HY-14398-10MM-1ML
Celecoxib 10Mm 1Ml Dmso Soluti
Medchemexpress LLC Rosuvastatin lactone | 503610-43-3 | 98.6% | 463.52 | 50 MG
Rosuvastatin lactone is a metabolite of Rosuvastatin, an HMG-CoA inhibitor. It is intended for research use only and is not sold to patients. This product appears as a white to off-white solid.
- Purity: 98.6%
- Molecular weight: 463.52
- Chemical formula: C22H26FN3O5S
- Shipping: Room temperature in continental US
- Storage: Powder at -20°C for 3 years or 4°C for 2 years
- Storage: In solvent at -80°C for 6 months or -20°C for 1 month
- Solubility: 125 mg/mL in DMSO
Apexbio Technology LLC Tiamulin fumarate 55297-96-6 250mg
Tiamulin fumarate is a semi-synthetic antibiotic belonging to the pleuromutilin class specifically inhibiting bacterial protein synthesis Its primary antibacterial activity targets Gram-positive bacteria certain Gram-negative bacteria and mycoplasmas by binding to the bacterial 50S ribosomal subunit thereby blocking peptide chain elongation Laboratory studies commonly utilize Tiamulin fumarate for investigating bacterial susceptibility mechanisms antibiotic resistance profiles and antimicrobial efficacy in veterinary pathogens It is applied predominantly in veterinary research settings involving swine mycoplasmal pneumonia swine dysentery and chronic respiratory infections in poultry In vitro assays demonstrate antibacterial activity with reported minimum inhibitory concentration (MIC) values often in the low micromolar range and inhibitory concentrations (IC50) varying depending on bacterial strain and experimental conditions
U.S. Pharmacopeia Climbazole | 38083-17-9 | MFCD00055505 | 400mg
Climbazole | Mol Wt: 292.764 | 38083-17-9 | MFCD00055505 | 400mg
Medchemexpress LLC Fostamatinib Disodium | 1025687-58-4 | 98.3% | 25 MG
Fostamatinib Disodium is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Oral proagent of active compound R406
- Orally available and competitive Syk/FLT3 inhibitor
- Inhibits Lyn and Lck
Apexbio Technology LLC Ciclopirox 29342-05-0 200mg
Ciclopirox is a synthetic antifungal compound with broad-spectrum activity against dermatophytes yeasts and molds It disrupts fungal membranes and interferes with essential enzymes inhibiting cell growth and replication Ciclopirox also has antibacterial properties against select Gram-positive and Gram-negative bacteria In vitro it demonstrates anti-inflammatory and anticancer activities suggesting its potential in research on fungal infections inflammation and tumorigenesis The compound s inhibitory concentrations (IC50) in antifungal assays typically range from 0 5 to 5 g/mL depending on the target species and conditions Ciclopirox is used to study fungal pathogenicity and develop therapies for dermatopharmacology and oncology
Apexbio Technology LLC Fluticasone propionate 80474-14-2 50mg
Fluticasone propionate is a synthetic glucocorticoid receptor (GR) agonist with high receptor selectivity and affinity It exerts anti-inflammatory and immunosuppressive actions by interacting with intracellular GR thereby influencing gene expression pathways and downstream cytokine responses This compound has been widely utilized in biomedical research to study inflammatory signaling mechanisms glucocorticoid receptor mediated transcriptional regulation and immune responses associated with asthma allergic rhinitis and related inflammatory diseases Reported in vitro studies demonstrate fluticasone propionate s GR agonist activity with an IC50 value in the subnanomolar range (approximately 0 5 nM) supporting its frequent utilization as a standard GR agonist in receptor-binding assays and inflammation-related experiments
Medchemexpress LLC Rosuvastatin lactone | 503610-43-3 | 97.0% | 463.52 | 25 MG
Rosuvastatin lactone is a metabolite of Rosuvastatin and an HMG-CoA inhibitor. It is intended for research use only.
- Metabolite of Rosuvastatin
- HMG-CoA inhibitor
- For research use only
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO (125 mg/mL)
Apexbio Technology LLC Metoprolol Tartrate 56392-17-7 10mM (in 1mL DMSO)
Metoprolol Tartrate (CAS 56392-17-7) is a selective 1-adrenergic receptor antagonist employed primarily for cardiovascular research purposes By specifically inhibiting 1-adrenergic receptors located predominantly in cardiac tissue it reduces sympathetic influences on heart rate and myocardial contractility Clinical research has indicated that genetic polymorphisms in 1-adrenergic receptors significantly affect individual hypertensive responses to treatment with metoprolol Due to its targeted mode of action and known genetic modulatory effects it is widely utilized in hypertension and cardiovascular pharmacogenomics studies
Apexbio Technology LLC Tivantinib (ARQ 197) 905854-02-6 100mg
Tivantinib (ARQ 197 CAS 905854-02-6) is a selective orally bioavailable small molecule inhibitor of the receptor tyrosine kinase c-MET (hepatocyte growth factor receptor) working through a non-ATP-competitive binding mechanism Tivantinib inhibits recombinant human c-MET with a Ki value of approximately 355 nmol/L It also demonstrates modest inhibitory activity against VEGFR-3 Pim-1 calmodulin-dependent kinase II delta and p21-activated kinase 3 In vitro studies reveal cytotoxicity against various human tumor cell lines (EC50 60-600 nmol/L) independent of c-MET gene amplification or MET protein expression Mechanistically it induces mitotic arrest and apoptosis Tivantinib is used experimentally in tumor biology research showing anti-tumor activities across multiple cancer xenograft models
Apexbio Technology LLC Esomeprazole Sodium 161796-78-7 50mg
Esomeprazole Sodium the S-enantiomer of omeprazole functions pharmacologically as a proton pump inhibitor (PPI) modulating gastric acid secretion through selective inhibition of the H /K -ATPase enzyme in gastric parietal cells By irreversibly binding covalently to the sulfhydryl groups of this enzyme esomeprazole sodium suppresses gastric acid secretion thus serving as an experimental tool in biomedical research exploring acid-related gastrointestinal conditions including erosive esophagitis and gastroesophageal reflux disease (GERD) Reported IC50 values for inhibition of H /K -ATPase activity range approximately from 2 8 M highlighting usage in studies investigating gastric acid regulation and related signaling pathways at the molecular and cellular level