Drug Standards
Apexbio Technology LLC Bromhexine HCl 611-75-6 10g
Bromhexine Hydrochloride is an expectorant compound utilized frequently in respiratory research to examine mucolytic mechanisms It functions primarily by disrupting acidic polysaccharide fibers within bronchial mucus reducing mucus viscosity and facilitating mucociliary clearance The compound is routinely employed in in vitro studies involving respiratory epithelial cells and ex vivo respiratory tract tissues to investigate its pharmacological influence on mucus production and secretion Reported IC50 values for Bromhexine Hydrochloride in mucolytic assays typically range between 30-50 M under standard experimental conditions Its applications extend to the study of respiratory disorders associated with abnormal mucus secretion enabling researchers to better characterize molecular pathways involved in mucus regulation and investigate potential therapeutic targets
Medchemexpress LLC Sarafloxacin hydrochloride | 91296-87-6 | 98.13% | 100 MG
Sarafloxacin hydrochloride is a quinolone antibiotic agent registered for use against poultry diseases. It has been shown to be effective in treating channel catfish infected with *E. ictaluri*.
- Quinolone antibiotic agent
- Registered for use against poultry diseases
- Efficacious in treating channel catfish infected with *E. ictaluri*
- Inhibitory level is strain dependent for tested bacteria
Medchemexpress LLC Detomidine hydrochloride | 90038-01-0 | 99.83% | 1 ML
Detomidine hydrochloride is an imidazole derivative and a potent α2-adrenergic agonist. It produces dose-dependent analgesic effects. This product is for research use only and not sold to patients.
- Potent α2-adrenergic agonist
- Produces dose-dependent analgesic effects
- Exhibits cardiac and respiratory effects
- Has an antidiuretic action
- Available in solid and solution forms
- For research use only
Apexbio Technology LLC Bromfenac Sodium 91714-93-1 10mM (in 1mL DMSO)
Bromfenac Sodium (CAS 91714-93-1) is a nonsteroidal anti-inflammatory small molecule compound characterized primarily by its capacity to inhibit cyclooxygenase enzymes (COX-1 and COX-2) By targeting these enzymes Bromfenac Sodium disrupts prostaglandin biosynthesis subsequently modulating inflammatory pathways and responses In biomedical research Bromfenac Sodium serves as a useful pharmacological tool to investigate inflammation signaling pathways and prostaglandin-mediated processes in various experimental models
Apexbio Technology LLC Cabozantinib (XL184, BMS-907351) 849217-68-1 10mM (in 1mL DMSO)
Cabozantinib (XL184 BMS-907351 CAS 849217-68-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) notably VEGFR2 MET and RET with reported IC50 values of 0 035 nmol/L 1 3 nmol/L and 5 2 nmol/L respectively Acting by blocking downstream phosphorylation events cabozantinib disrupts RTK-mediated cell signaling pathways fundamental to cellular proliferation and differentiation In vitro studies utilizing RET-mutant TT cells showed dose-dependent inhibition of RET autophosphorylation (IC50 85 nmol/L) and reduced cellular proliferation In vivo experiments using TT-cell xenograft mouse models demonstrated tumor growth suppression and decreased serum calcitonin levels Cabozantinib serves as a valuable tool in oncology and RTK-related signaling research
Apexbio Technology LLC Doxazosin Mesylate 77883-43-3 10mM (in 1mL DMSO)
Doxazosin Mesylate (CAS 77883-43-3) is a selective long-acting antagonist of 1-adrenoceptors It has been reported to enhance serotonin (5-HT)-induced contraction responses in a dose-dependent manner In animal models doxazosin administration decreases alcohol consumption and elevates water intake Furthermore doxazosin demonstrates anti-inflammatory effects inhibiting TNF- production in LPS-induced systemic inflammation and reducing MCP-1 expression in LPS-mediated pulmonary inflammation It similarly attenuates paw edema in delayed-type hypersensitivity and slightly reduces MCP-1 in a thioglycolate-induced peritoneal inflammation model
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 200 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits little to no activity at other steroid receptors and also possesses anti-viral activity. Its applications span immunology, anti-infection, and metabolic research.
- Potent topical anti-inflammatory corticosteroid
- Selective glucocorticoid receptor agonist (KD of 0.5 nM)
- Exhibits minimal activity at other steroid receptors
- Possesses anti-viral activity
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM
- Targets glucocorticoid receptor, endogenous metabolite, enterovirus, and ADC payload
- Relevant to immunology/inflammation, vitamin D related/nuclear receptor, metabolic enzyme/protease, anti-infection, and antibody-drug conjugate/ADC related pathways
Apexbio Technology LLC Dipyridamole 58-32-2 500mg
Dipyridamole (CAS 58-32-2) is an orally bioactive phosphodiesterase (PDE) inhibitor that acts primarily by inhibiting the cellular uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells This mechanism elevates extracellular adenosine levels subsequently modulating adenosine-dependent pathways involved in platelet function vasodilation and coagulation processes Dipyridamole exhibits antiplatelet properties and is commonly used in research related to secondary stroke prevention Additionally it has demonstrated the ability to induce apoptosis in certain tumor cell lines highlighting potential applications in oncology research
Apexbio Technology LLC Dipyridamole 58-32-2 10mM (in 1mL DMSO)
Dipyridamole (CAS 58-32-2) is an orally bioactive phosphodiesterase (PDE) inhibitor that acts primarily by inhibiting the cellular uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells This mechanism elevates extracellular adenosine levels subsequently modulating adenosine-dependent pathways involved in platelet function vasodilation and coagulation processes Dipyridamole exhibits antiplatelet properties and is commonly used in research related to secondary stroke prevention Additionally it has demonstrated the ability to induce apoptosis in certain tumor cell lines highlighting potential applications in oncology research
Apexbio Technology LLC Ketorolac tromethamine salt 74103-07-4 1g
Ketorolac tromethamine salt (CAS 74103-07-4) is a small-molecule inhibitor that targets cyclooxygenase (COX) enzymes non-selectively resulting in potent analgesic activity through inhibition of prostaglandin synthesis This compound is commonly utilized in biomedical research to investigate pathways related to inflammation pain perception and prostaglandin-mediated physiological responses
Apexbio Technology LLC Ganciclovir 82410-32-0 10mM (in 1mL DMSO)
Ganciclovir (DHPG) is an antiviral compound classified as a nucleoside analog primarily utilized in research targeting cytomegalovirus (CMV) infections Its active pharmacological mechanism involves phosphorylation by viral thymidine kinase enzymes subsequently converting to ganciclovir triphosphate which inhibits viral DNA polymerase to suppress viral replication It displays inhibitory activity against herpesviruses including human cytomegalovirus herpes simplex virus types I and II and Epstein-Barr virus Research indicates ganciclovir also reduces proliferation and activation of microglia as demonstrated in experimental animal models suggesting utility for studies involving neuroinflammatory and glial cell proliferation processes Literature-reported IC50 against human CMV polymerase is approximately 0 25 M illustrating its potential use in antiviral mechanism assays and neuroscience-related inflammation research
Medchemexpress LLC 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1) | 65473-14-5 | 99.7% | 100 MG
Naftifine hydrochloride is an antibiotic with antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. It can be used for the research of superficial dermatomycoses inhibition.
- Antifungal activity against dermatophytes
- Antifungal activity against aspergilli
- Antifungal activity against Sporothrix schenckii
- Antifungal activity against yeasts of the genus Candida
- Used for research of superficial dermatomycoses inhibition
Medchemexpress LLC Tofacitinib impurity 2 | 95.4% | 436.69 | 100 MG
Tofacitinib impurity 2 is an impurity of Tofacitinib (HY-40354).
- For research use only
Medchemexpress LLC Fenoldopam mesylate | 67227-57-0 | 99.94% | 5 MG
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor. It exhibits anti-hypertensive effects, anti-cancer cell proliferation activity, and can induce cell apoptosis. This compound is suitable for research use only.
- Functions as a D1 receptor agonist
- Acts as a novel LSD1 inhibitor with an IC50 of 0.8974 μM
- Exhibits anti-hypertensive effects
- Demonstrates anti-cancer cell proliferation activity
- Can induce cell apoptosis
- Shows antiproliferative activity against RCC cell lines
- Induces cell apoptosis in ACHN cells in a dose-dependent manner