Drug Standards
Medchemexpress LLC Enzalutamide (standard) | 915087-33-1 | 100.0% | C21H16F4N4O2S | 25 MG
Enzalutamide (Standard) is the analytical standard of Enzalutamide, intended for research and analytical applications. It acts as an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells and is also an autophagy activator. This analytical standard grade compound serves as a reference for assays, commonly utilized in qualitative, quantitative, and methodological research experiments involving techniques such as HPLC, GC, and MS.
- Analytical standard of enzalutamide
- Intended for research and analytical applications
- Functions as an androgen receptor (AR) antagonist
- Autophagy activator
- Serves as a reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Compatible with techniques such as HPLC, GC, and MS
Selleck Chemical LLC RO4929097 5mg 847925-91-1
RO4929097 is a ? secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of A?40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC LAPATINIB DITOSYLATE 500MG
Also available in 25 mg 50 mg 100 mg 200 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50 10.8/9.2 nM for EGFR/ErbB2). purity: 99%
Medchemexpress LLC Ticagrelor impurity 12 | 220241-61-2 | 99.6% | 385.88 | C15H20ClN5O3S | 10 MG
Ticagrelor impurity 12 is an analytical standard used as an impurity reference for ticagrelor in research and analytical testing. The compound is characterized by high purity and defined physicochemical properties for method development and quality control.
- High purity standard (99.6%) for analytical assays.
- Molecular weight 385.88 g/mol.
- CAS number 220241-61-2 for unambiguous identification.
- Recommended storage under nitrogen at -20°C; in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month.
- Intended for research and analytical use (not for human consumption).
Medchemexpress LLC Cpd-1224 | 2891620-68-9 | 99.8% | 855.40 | C43H47ClN8O7S | 10 MG
CPD-1224 is an orally active small-molecule inhibitor of anaplastic lymphoma kinase (ALK) that links an ALK-binding moiety to a cereblon ligand to induce target degradation. It degrades EML4-ALK and resistant mutant forms, shows tumor growth inhibition in preclinical studies, and is supplied for research applications.
- Orally active anaplastic lymphoma kinase (ALK) inhibitor that promotes target degradation.
- Effective against resistance mutations L1196M and G1202R.
- High purity (>99.8%) suitable for analytical and biological assays.
- Soluble in DMSO at approximately 14.29 mg/mL for in vitro studies.
- Available in small-molecule quantities for preclinical research.
Sigma Aldrich Fine Chemicals Biosciences D-(+)-Maltose monohydrate BioXtra | 6363-53-7 | MFCD00149343 | 500g
D-(+)-Maltose monohydrate BioXtra | 99% | MW: 360.31 | 6363-53-7 | MFCD00149343 | 500g
Medchemexpress LLC Proguanil hydrochloride | 637-32-1 | MFCD01732193 | 99.2% | 290.19 g·mol⁻¹ | C11H17Cl2N5 | 10 MG
Proguanil hydrochloride is an antimalarial prodrug that is metabolized to cycloguanil and acts as a dihydrofolate reductase (DHFR) inhibitor. It is supplied as a white to off-white solid for research use, with high purity and solvent solubility suitable for in vitro testing.
- Antimalarial prodrug converted to cycloguanil.
- Dihydrofolate reductase (DHFR) inhibitor used in antiparasitic research.
- High purity suitable for analytical and biological assays.
- Soluble in DMSO at high concentration; sonication may be required.
- Available in small research pack sizes for convenience.
Apexbio Technology LLC FITC-Dextran (MW 150000) 10mg
FITC-Dextran MW 150000 (CAS 60842-46-8) is a fluorescent polysaccharide probe composed of dextran covalently labeled with fluorescein isothiocyanate (FITC) It is designed as a macromolecular marker to study cell membrane permeability and barrier integrity in biological systems FITC-Dextran MW 150000 functions by emitting detectable green fluorescence after excitation enabling quantitative analysis of transport dynamics and permeability Based on these properties FITC-Dextran MW 150000 is employed in research applications such as permeability assays evaluation of barrier integrity (blood-brain intestinal vascular) intracellular trafficking studies and assessment of fluid-phase uptake processes
Medchemexpress LLC Doramectin | 117704-25-3 | MFCD00894747 | >95.0% | 10 MG
Doramectin (Standard) is the analytical reference standard of doramectin, a macrocyclic lactone antiparasitic derivative of ivermectin. It is provided for research and analytical applications and is characterized by CAS 117704-25-3, molecular formula C50H74O14, and molecular weight 899.11. The material is supplied in solid form and as a solution for use in assay, calibration, and method development.
- Analytical standard suitable for assay and method development.
- Characterized by CAS 117704-25-3 and molecular weight 899.11.
- Available as solid and DMSO solution formats for flexible use.
- Intended for research and analytical applications.
- Certificate of analysis available; confirm supplier-specific purity before use.
Apexbio Technology LLC Atazanavir sulfate (BMS-232632-05) 229975-97-7 5mg
Atazanavir sulfate (BMS-232632-05) (CAS 229975-97-7) is a small-molecule inhibitor targeting HIV-1 protease It is designed to inhibit protease-mediated processing of HIV gag and gag-pol polyproteins thereby blocking viral particle maturation Atazanavir sulfate exerts its biological activity primarily through selective inhibition of HIV-1 protease In in vitro studies atazanavir sulfate demonstrates inhibitory activity against HIV-1 strains with reported IC50 values ranging from 2 to 5 nM Based on these pharmacological properties atazanavir sulfate holds research potential in antiviral studies focused on HIV replication mechanisms and investigations of drug metabolism mediated by hepatic CYP systems
Medchemexpress LLC Des(methylpiperazinyl-N-methyl) imatinib dimer impurity | 1365802-18-1 | MFCD28899574 | 96.1% | C52H48N12O2 | 10MG
Imatinib Impurity E is an analytical reference standard used to characterize and quantify a known impurity of imatinib (CAS 1365802-18-1). Supplied as a high-purity compound (96.05%), it is intended for research and quality-control workflows such as impurity profiling, method development, and stability testing.
- Serves as an analytical reference standard for impurity identification.
- Supports HPLC, LC-MS, and method validation workflows.
- Supplied with a certificate of analysis for traceability.
- High reported purity suitable for quantitative analysis.
- Available in small laboratory pack sizes for analytical use.
Medchemexpress LLC Neratinib (Standard) | 698387-09-6 | 99.3% | 557.04 | 25 MG
Neratinib (Standard) is the analytical standard of Neratinib, intended for research and analytical applications. Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
- Analytical standard for Neratinib
- Used for research and analytical applications
- Orally available
- Irreversible
- Highly selective HER2 and EGFR inhibitor
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
Medchemexpress LLC Lidocaine (Standard) | 137-58-6 | 100.0% | 50 MG
Lidocaine (Standard) is the analytical standard of Lidocaine, intended for research and analytical applications. It inhibits sodium channels involving complex voltage and using dependence, and decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. It is an amide derivative and has potential for the research of ventricular arrhythmia.
- Analytical standard for research and analytical applications
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Potential for research of ventricular arrhythmia
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Apexbio Technology LLC Salmeterol xinafoate 94749-08-3 50mg
Salmeterol xinafoate (CAS 94749-08-3) is a long-acting 2-adrenergic receptor agonist that induces smooth muscle relaxation leading to bronchodilation and vasodilation In vitro studies show that salmeterol reduces retinal M ller cell death by inhibiting IRS-1 (Ser307) phosphorylation implicating -adrenergic signaling in cell survival pathways In vivo experiments demonstrate that salmeterol suppresses pro-inflammatory cytokine production in allergen-stimulated murine models and attenuates inflammatory responses via modulation of dendritic cells Clinically salmeterol has been shown to enhance peak expiratory flow in asthma and is studied in combination therapies for persistent asthma supporting its utility in respiratory and immunological research
Apexbio Technology LLC Fenoldopam 67227-56-9 50mg
Fenoldopam is a small-molecule partial agonist targeting dopamine D1-like receptors It is designed to selectively activate these receptors thereby mediating peripheral vasodilation and modulating vascular resistance Fenoldopam exerts its biological activity primarily through D1-like receptor activation In in vitro studies Fenoldopam demonstrates partial agonist activity with an EC50 value of approximately 57 nM Additionally it exhibits inhibitory activity against 2-adrenoceptors with a reported Ki of 15 25 nM Based on these pharmacological properties Fenoldopam holds research potential in studies of cardiovascular regulation receptor pharmacodynamics and selective receptor ligand profiling