Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Medronic acid European Pharmacopoeia (EP) Reference Standard | 1984-15-2 | MFCD00002139 |
Medronic acid European Pharmacopoeia (EP) Reference Standard | Mol Wt: 176 | 1984-15-2 | MFCD00002139 |
Sigma Aldrich Fine Chemicals Biosciences Thiamine pyrophosphate >=95% | 154-87-0 | MFCD00038740 | 25G
Thiamine pyrophosphate >=95% | Purity: >=95% | Mol Wt: 460.77 | 154-87-0 | MFCD00038740 | 25G
Apexbio Technology LLC Edoxaban tosylate monohydrate 1229194-11-9 10mM (in 1mL DMSO)
Edoxaban tosylate monohydrate (CAS 1229194-11-9) is a small-molecule oral anticoagulant that selectively and directly inhibits coagulation factor Xa (FXa) a serine protease central to the thrombin generation pathway In vitro edoxaban tosylate monohydrate demonstrates high affinity for free FXa (Ki 0 561 nM) and the prothrombinase complex (Ki 2 98 nM) with over 10 000-fold selectivity for FXa versus related targets It effectively prolongs prothrombin time and activated partial thromboplastin time in human plasma without affecting platelet aggregation induced by ADP collagen or U46619 In vivo it exhibits dose-dependent inhibition of thrombosis in rodent models with minimal prolongation of bleeding time Edoxaban tosylate monohydrate is widely used in thrombosis and anticoagulation research
Medchemexpress LLC Ticagrelor impurity 11 | 220352-36-3 | ≥95.0% | C10H8F2O2 | 5 G
Ticagrelor impurity 11 is an impurity of Ticagrelor. It appears as a solid with a molecular weight of 198.17. This product is for research use only.
- Purity: ≥95.0%
- Storage as powder: -20 °C for 3 years, 4 °C for 2 years
- Storage in solvent: -80 °C for 6 months, -20 °C for 1 month
Apexbio Technology LLC Robenidine hydrochloride 25875-50-7 100mg
Robenidine hydrochloride (CAS 25875-50-7) is a small-molecule antimicrobial agent with activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) It is designed to inhibit these bacterial pathogens thereby interfering with microbial survival Robenidine hydrochloride exerts its biological activity primarily through disruption of microbial cell membrane integrity In in vitro studies Robenidine hydrochloride demonstrates inhibitory activity with MIC50 values of 8 1 M for MRSA and 4 7 M for VRE Based on these pharmacological properties Robenidine hydrochloride holds research potential in the fields of microbial infection drug resistance and the development of novel anti-infective strategies
Medchemexpress LLC Granisetron Hydrochloride | 107007-99-8 | 99.9% | C18H25ClN4O | 1 ML
Granisetron (Hydrochloride), also known as BRL 43694A, is a serotonin 5-HT3 receptor antagonist. It is utilized as an antiemetic to alleviate nausea and vomiting, particularly following chemotherapy.
- Serotonin 5-HT3 receptor antagonist
- Used as an antiemetic
- Treats nausea and vomiting following chemotherapy
Medchemexpress LLC Capecitabine | 154361-50-9 | 99.99% | C15H22FN3O6 | 1 ML
Capecitabine is an oral proagent that converts to its active metabolite, 5-FU, via thymidine phosphorylase. It is an anti-cancer chemotherapy drug, classified as an antimetabolite. Capecitabine is converted into 5′-deoxy-5-fluorocytidine (5′DFCR), 5′-deoxy-5-fluorouridine (5′DFUR), and 5-FU by carboxylesterases (CES1 and 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) in both the liver and tumor. Capecitabine induces a significant cytotoxic effect in vitro only at high concentrations.
- Intended for research use only
- Converted to active metabolite, 5-FU, in the liver and tumor
- Classified as an antimetabolite
- Induces cytotoxic effect in vitro at high concentrations
Medchemexpress LLC Doxazosin (UK 33274) | 74191-85-8 | 99.9% | C23H25N5O5 | 100 MG
Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It is a long-lasting inhibitor of α1-adrenoceptors, widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. Doxazosin may also have a direct inhibitory effect on cholesterol synthesis, independent of the LDL receptor, which could lead to an upregulation of the LDL receptor, increasing lipoprotein cholesterol importation and reducing LDL cholesterol in the medium. This product is for research use only and not sold to patients.
- Selectively antagonizes postsynaptic α1-adrenergic receptors.
- Long-lasting α1-adrenoceptor inhibitor.
- Used for benign prostatic hyperplasia and lower urinary tract symptoms.
- Potential to inhibit cholesterol synthesis.
- Effective as monotherapy or in combination with beta-blockers.
- For research use only.
Medchemexpress LLC Cytidine, 2'-deoxy-2',2'-difluoro-, hydrochloride | 122111-03-9 | 99.9% | C9H12ClF2N3O4 | 1 ML
Gemcitabine hydrochloride is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. It inhibits DNA synthesis and repair, leading to autophagy and apoptosis.
- Targets DNA/RNA synthesis
- Functions as a nucleoside antimetabolite/analog
- Induces autophagy and apoptosis
- Used in cancer research
Apexbio Technology LLC Lenalidomide hydrochloride 1243329-97-6 100mg
Lenalidomide hydrochloride is a small-molecule immunomodulator that inhibits TNF- secretion It is designed to modulate immune signaling pathways thereby regulating T cell activation and cytokine production Lenalidomide hydrochloride exerts its biological activity primarily by inhibiting TNF- secretion (IC50 13 nM) enhancing IL-2 and soluble IL-2 receptor (sIL-2R) production and inducing CD28 tyrosine phosphorylation followed by NF- B activation in T cells It also impairs autoubiquitination of cereblon (CRBN) a substrate receptor of the E3 ligase complex affecting downstream protein expression including c-Myc IRF4 and p21(WAF-1) Based on these pharmacological properties lenalidomide hydrochloride holds research potential in oncology and inflammation studies focusing on immune modulation
Selleck Chemical LLC Lanabecestat (AZD3293) 5mg 1383982-64-6 LY3314814
Lanabecestat (AZD3293, LY3314814) is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor with an inhibitory constant Ki? of 0.4 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC Plerixafor 25MG
Also available in 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4. Purity 100%
TARGETMOL CHEMICALS INC Flumazenil 500MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. Flumazenil is an imidazobenzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Purity 99.62%