Hydrochlorides
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 500 MG
Nilotinib hydrochloride dihydrate is the hydrochloride dihydrate salt of nilotinib (AMN107), an orally active Bcr-Abl tyrosine kinase inhibitor used in research on chronic myelogenous leukemia. Supplied as a solid powder for laboratory research, the material is provided with assay data and manufacturer storage guidance for short- and long-term handling.
- High purity (99.9%).
- Solid powder form suitable for research use.
- Molecular formula C28H27ClF3N7O3; molecular weight 602.01 g/mol.
- Available in multiple pack sizes, including 500 mg.
- Store sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 50 MG
GW405833 (L768242) hydrochloride is a potent and selective cannabinoid receptor 2 (CB2) agonist, exhibiting high affinity for CB2 over CB1. It also functions as a non-competitive CB1 antagonist and can inhibit cAMP production stimulated by Forskolin. This compound notably inhibits glycolysis by down-regulating HIF-1α, suggesting its role in alleviating acute liver failure (ALF).
- Potent, selective cannabinoid receptor 2 (CB2) agonist.
- Exhibits non-competitive CB1 antagonist activity.
- Inhibits glycolysis by down-regulating HIF-1α.
- Alleviates acute liver failure (ALF).
- Reverses mechanical pain in neuropathic and inflammatory pain models.
Medchemexpress LLC Gr 55562 dihydrochloride | 159533-25-2 | 99.0% | 448.39 | C23H27Cl2N3O2 | 5 MG
GR 55562 dihydrochloride is a selective serotonin 5-HT1B and 5-HT1D receptor antagonist supplied as the dihydrochloride salt for research use. It is commonly used in receptor pharmacology and behavioral studies to probe serotonergic mechanisms in vitro and in vivo.
- Selective 5-HT1B/5-HT1D receptor antagonist.
- Suitable for in vivo and in vitro studies.
- High purity (99.0%).
- Provided as the dihydrochloride salt for improved solubility.
- Available in small quantities for research use (5 MG, 10 MG).
- Includes documentation: datasheet, COA, and SDS.
Medchemexpress LLC 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 137.63 | C4H8ClNS | 100 MG
2-Iminothiolane hydrochloride is a thiolating reagent that converts primary amines into free sulfhydryl (-SH) groups for protein, peptide, and oligosaccharide modification. It reacts under mild conditions (pH 7-10) to form an amidine linkage while introducing a reactive thiol, enabling subsequent labeling, crosslinking, or conjugation for research applications.
- Introduces free sulfhydryl groups to primary amines.
- Reacts efficiently at neutral to slightly basic pH (7-10).
- Forms stable amidine linkages upon conjugation.
- Enables protein and peptide labeling and crosslinking.
- Suitable for bioconjugation and assay development.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 g/mol | C4H8ClNS | 50 MG
2-Iminothiolane hydrochloride is a thiolating reagent that introduces sulfhydryl (-SH) groups into primary amines of proteins, peptides, and oligosaccharides for bioconjugation and cross-linking. Supplied as a white to off-white solid, it is intended for research use and should be stored sealed and away from moisture.
- High purity suitable for biochemical applications
- Efficient thiolation of primary amines under mild conditions
- Useful for protein and peptide modification and cross-linking
- Solid form easy to weigh and dissolve for reactions
- Stable when stored sealed and protected from moisture
Medchemexpress LLC N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g/mol | C22H16N4O3 | 25 MG
VU-29 (N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide, CAS 890764-36-0) is a research small molecule that acts as a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5). Supplied as a high-purity solid, it is intended for use in in vitro and in vivo pharmacology and neuroscience research.
- Acts as a positive allosteric modulator of mGlu5 receptor.
- High purity suitable for research applications.
- Solid form for convenient handling and storage.
- Available in small mass packages for preclinical studies.
- Characterized by standard chemical identifiers for traceability.
Medchemexpress LLC Queuine dihydrochloride | 86496-18-6 | 350.20 | 50 MG
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT), incorporated into eukaryotic tRNA to promote modification. Its deficiency enhances aerobic glycolysis, inhibits oxidative phosphorylation, and promotes Warburg metabolism. It is useful for autoimmune diseases and cancer metabolic regulation and is for research use only.
- Selective substrate for tRNA guanine transglycosylase.
- Promotes tRNA modification in eukaryotic cells.
- Impacts mitochondrial function and Warburg metabolism.
- Deficiency linked to enhanced glycolysis and inhibited oxidative phosphorylation.
- Potential for autoimmune disease and cancer metabolic research.
- Reduces lactate dehydrogenase activity and lactate production.
- Natural TGT substrate, replacing guanine (G34) in tRNA.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 25 MG
VU-1545 is a potent metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM) with a Ki of 156 nM and an EC50 of 9.6 nM. It promotes AKT activation, efficiently doing so at concentrations as low as 0.1 and 1.0 μM. Studies have shown that VU-1545 at 10 and 100 μM promotes Akt phosphorylation. This compound is used for research purposes and is not intended for patient use.
- Potent mGluR5 positive allosteric modulator
- Ki of 156 nM for mGluR5
- EC50 of 9.6 nM for mGluR5
- Promotes AKT activation in neuronal cells
- Efficiently promotes Akt phosphorylation at 10.0 μM and 100.0 μM
Medchemexpress LLC VU 0357121 | 433967-28-3 | C17H17F2NO2 | 100 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes. It enhances glutamate sensitivity of mGlu5, likely due to an interaction at a site on the receptor distinct from the MPEP binding site, and does not possess mGlu5 NAM activity. It is for research use only.
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
- A809V/rmGlu5 mutation inhibited the ability to shift the glutamate concentration response curve
- Response is not altered by the F585I/rmGlu5 mutation
Medchemexpress LLC Kevetrin hydrochloride | 66592-89-0 | 98.0% | 179.67 | 50MG
Kevetrin hydrochloride is a potent activator of p53, inducing apoptosis in both TP53 wild-type and mutant acute myeloid leukemia cells. This compound demonstrates preferential cytotoxic activity against blast cells and is intended for research use only.
- Potent activator of p53.
- Induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells.
- Exhibits preferential cytotoxic activity against blast cells.
- Significantly inhibits KASUMI-1 cell growth.
- Induces metallothionein (MT) expression in acute myeloid leukemia cells.
- Increases p53 mRNA and protein levels, and induces p21 protein production.
- Inhibits tumor growth and extends survival time in xenograft models.
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 5 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor that effectively targets multiple LOX enzymes, with IC50 values ranging from 0.3 μM to 3.7 μM. Its excellent skin penetrability facilitates the reduction of collagen deposition and significantly enhances the appearance of scars.
- Acts as an irreversible lysyl oxidase inhibitor
- Effective against various LOX enzyme types
- Exhibits excellent skin penetrability
- Reduces collagen deposition
- Significantly improves scar appearance
- High permeability observed in Caco-2 and MDCKII cell assays
- Inhibits LOX and reduces crosslinking in porcine injury models
- Topical application improves scar appearance in murine and porcine models
Medchemexpress LLC DMPQ dihydrochloride | 1123491-15-5 | MFCD02262123 | >99.10% | 339.22 | 25 MG
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM. It is also described as 5,7-Dimethoxy-3-(4-pyridinyl) quinoline.
- Potent and selective inhibitor of human PDGFRβ
- IC50 of 80 nM
- For research use only
- Target: PDGFR
- Pathway: Protein Tyrosine Kinase/RTK
Medchemexpress LLC RS-102221 hydrochloride | 187397-18-8 | 98.0% | 649.08 g/mol | C27H32ClF3N4O7S | 25 MG
RS-102221 hydrochloride is the hydrochloride salt of a selective 5-HT2C receptor antagonist commonly used in neuroscience research. It demonstrates high affinity for 5-HT2C receptors and is supplied in both solid and solution forms for in vitro and in vivo studies, with specified purity and storage recommendations.
Medchemexpress LLC Nitrocaramiphen (hydrochloride) | 98636-73-8 | MFCD00673872 | 99.6% | 370.87 | C18H27ClN2O4 | 10 MG
Nitrocaramiphen hydrochloride is a selective muscarinic M1 receptor antagonist for research use, commonly applied in pharmacology and neuroscience to probe cholinergic signaling. It blocks muscarine-induced hyperpolarization in muscle fibers and is supplied as a purified solid for in vitro assays.
- Selective muscarinic M1 receptor antagonist (Ki 5.5 nM).
- Inhibits muscarine-induced hyperpolarization in muscle fibers.
- High purity solid suitable for in vitro research (purity 99.6%).
- Compact supply size for small-scale studies (10 mg).
- Stable when stored sealed and protected from moisture.