Hydrochlorides
Selleck Chemical LLC Tirofiban S3085-25mg
Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 50 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with an EC50 of 19.8 nM. Intended for research use only, this solid compound appears white to off-white. While it demonstrates better stability in Human Liver Microsomes, its less than ideal PK properties prevent its use as an in vivo tool.
- Positive allosteric modulator (PAM) for mGlu4
- EC50 of 19.8 nM
- Purity of 99.42%
- Solid appearance, white to off-white color
- Exhibits better stability in HLM (63% remaining) compared to RLM (2% remaining)
- Target: mGluR
eMolecules 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | 98338-26-2 | MFCD16618478 | 1g
AstaTech | 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | 1g | 222806229 | 84194 | 95.000 | 98338-26-2 | MFCD16618478 | 273.012 | C7H15Br2N
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Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 25 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It exhibits better stability in HLM (63% remaining) compared to RLM (2% remaining). It is intended for research use only.
- mGlu4 positive allosteric modulator (PAM)
- EC50 of 19.8 nM
- Better stability in HLM (63% remaining) than RLM (2% remaining)
- For research use only
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 50 MG
RS-127445 hydrochloride is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. It is intended for research use only.
- Selective 5-HT2B receptor antagonist
- High-affinity binding
- Orally bioavailable
- Demonstrates 1000-fold selectivity
- Suitable for research applications
Medchemexpress LLC CP-24879 hydrochlori 10mM 1mL | 10141-51-2 | 1 ML
CP-24879 hydrochloride is a research compound that potently and selectively inhibits delta5 and delta6 desaturases. It is supplied as a 10 mM solution in DMSO (1 mL) for biochemical and cell-based studies of lipid metabolism and inflammatory pathways. CAS 10141-51-2; molecular formula C11H18ClNO; molecular weight 215.72 g·mol⁻¹; reported purity 99.59%.
- Potent dual delta5/delta6 desaturase inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL format.
- High reported purity suitable for research use.
- Appropriate for biochemical and cell-based lipid metabolism studies.
- Molecular formula C11H18ClNO; molecular weight 215.72 g·mol⁻¹.
eMolecules Broadpharm / 2-Iminothiolane HCl salt / 500mg / 686681063 / BP-27870 / 95.000 / 4781-83-3 / MFCD00216010 / 101.170 / C4H7NS
Broadpharm / 2-Iminothiolane HCl salt / 500mg / 686681063 / BP-27870 / 95.000 / 4781-83-3 / MFCD00216010 / 101.170 / C4H7NS
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 5 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). PXS-4787 hydrochloride also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts.
- Specific and effective pan-LOX (lysyl oxidase) inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces the deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 25 MG
RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It exhibits 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites.
- Selective and high affinity 5-HT2B receptor antagonist
- Orally bioavailable
- 1000-fold selectivity compared to other receptor and ion channel binding sites
- Potently displaces [3H]-5-HT from human recombinant 5-HT2B receptors
- Blocks 5-HT-evoked increases in intracellular calcium concentrations
Medchemexpress LLC 4-Hydroxytryptamine 1mg | 55206-11-6 | 387.41 | C14H21N5O6S | 1 MG
4-Hydroxytryptamine creatinine sulfate is the creatinine sulfate salt of 4-hydroxytryptamine (serotonin). It is a tryptamine derivative used as a research reagent and acts as a neurotransmitter agonist; reported activities include inhibition of [3H] norepinephrine uptake and modulation of norepinephrine release in animal studies.
- High purity: 97.9% (assay).
- Solid powder form, suitable for analytical and biological studies.
- Molecular weight 387.41 g·mol⁻¹.
- Chemical formula C14H21N5O6S.
- Provided in milligram-scale pack sizes for research use.
- Documentation available: COA, SDS, and elemental analysis report.
Medchemexpress LLC CS-VIP 8 hydrochloride | 961.40 | 5 MG
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (Kᵢ= 0.008 μM). It induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. This compound shows promise for research into hematological diseases like leukemia.
- Selective allosteric WDR5 protein inhibitor (Kᵢ= 0.008 μM).
- Induces conformational changes in the MLL1 complex.
- Leads to the dissociation of MLL1 from the complex.
- Inhibits MLL1 histone methyltransferase activity.
- Regulates HOX gene expression.
- Promising for research into hematological diseases such as leukemia.
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 100 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of the TGF-β type I receptor kinase (ALK5) used for biochemical and cell-based studies. It potently inhibits ALK5 kinase activity and reduces Smad2/3 phosphorylation in cellular assays, making it suitable for research on TGF-β/Smad signaling and related applications.
- Potent ALK5 inhibition, IC50 = 2.72 nM.
- Cellular activity: inhibits Smad2/3 phosphorylation in A549 cells, IC50 = 8.68 nM.
- High reported purity (99.22%).
- Supplied as the hydrochloride salt; available in research pack sizes including 100 mg.
- Molecular weight 334.85 g·mol-1; formula C14H11ClN4S2.
Medchemexpress LLC Ecopipam hydrochloride | 190133-94-9 | 99.5% | 350.28 | C19H21Cl2NO | 5 MG
Ecopipam hydrochloride is a potent, selective, orally active antagonist of dopamine D1 and D5 receptors used in biochemical and pharmacological research. It has nanomolar affinity and shows high selectivity versus other monoaminergic receptors, and is supplied in high-purity forms suitable for in vitro and in vivo studies.
- Potent, selective antagonist of dopamine D1 and D5 receptors.
- Nanomolar affinity supports sensitive pharmacological assays.
- Greater than 40-fold selectivity versus D2, D4, 5-HT, and α2a receptors.
- Suitable for preclinical studies of neuropsychiatric and metabolic disorders.
- Available as solid and as DMSO solution; provided at high purity.
Medchemexpress LLC Tp0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 50 MG
TP0427736 hydrochloride is the hydrochloride salt of a potent ALK5 (TGF-β type I receptor) kinase inhibitor for in vitro and preclinical research. It inhibits ALK5 with low-nanomolar potency and reduces Smad2/3 phosphorylation in cellular assays.
- Potent ALK5 inhibitor (ALK5 IC50 2.72 nM).
- Selective over ALK3 (ALK3 IC50 836 nM).
- Reduces Smad2/3 phosphorylation in A549 cells induced by TGF-β1 (8.68 nM).
- Molecular weight 334.85.
- Chemical formula C14H11ClN4S2.
- Purity 99.22%.
- Solid supplied as a 50 mg vial for laboratory research.
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 5 MG
This compound is a selective, high-affinity, and orally bioavailable antagonist of the 5-HT2B receptor, exhibiting a pKi of 9.5. It demonstrates significantly higher selectivity (1000-fold) for this receptor compared to numerous other receptor and ion channel binding sites.
- High affinity for the target receptor.
- Orally bioavailable.
- Shows high selectivity, reducing off-target effects.
- Effective in inhibiting serotonin-induced intracellular calcium increases.
- Proven antagonist activity in cellular assays.