Hydrochlorides
Medchemexpress LLC Co 101244 hydrochloride | 193356-17-1 | 99.9% | 377.90 | C21H28ClNO3 | 10 MG
Co 101244 hydrochloride (PD 174494 hydrochloride) is a selective antagonist of NR2B (GluN2B)-containing NMDA receptors used to study NMDA receptor pharmacology and neuronal signaling in vitro. The hydrochloride salt is characterized by formula C21H28ClNO3, molecular weight 377.90 g/mol, and supplier-reported purity near 99.9%. It is supplied in small-molecule formats for research assays.
- Selective antagonist of NR2B-containing NMDA receptors.
- High chemical purity for reproducible experimental results.
- Hydrochloride salt form for improved solubility in assay solvents.
- Suitable for in vitro pharmacology and receptor binding assays.
- Available in mg-scale solid and DMSO solution formats.
- Molecular weight and formula provided for dosing calculations.
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 50 MG
RS-127445 hydrochloride is a selective, high-affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. It demonstrates 1000-fold selectivity for this receptor compared to numerous other receptor and ion channel binding sites. It is intended for research use only.
- Selective 5-HT2B receptor antagonist
- High-affinity binding
- Orally bioavailable
- Demonstrates 1000-fold selectivity
- Suitable for research applications
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 100 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. While it exhibits less than ideal PK properties for in vivo use, it demonstrates better stability in HLM (63% remaining) compared to RLM (2% remaining).
- mGlu4 positive allosteric modulator
- Exhibits an EC50 of 19.8 nM
- Shows improved stability in HLM (63% remaining) compared to RLM (2% remaining)
- Soluble in DMSO (50 mg/mL)
- Targets mGluR in GPCR/G Protein and neuronal signaling pathways
Accela Chembio Inc 2-(methylsulfonyl)ethylamine Hydrochloride | 5g | 104458-24-4 | MFCD03840162 | 97+% | Shelf Life: 900 Days | Moisture Sensitive
2-(methylsulfonyl)ethylamine Hydrochloride | 5g | 104458-24-4 | MFCD03840162 | 97+% | Shelf Life: 900 Days | Moisture Sensitive
Chem-Impex International, Inc. 2-Aminoethylmethylsulfone Hydrochloride | 104458-24-4 | MFCD03840162 | 1G
2-Aminoethylmethylsulfone Hydrochloride, 104458-24-4, MFCD03840162, 1G
Medchemexpress LLC Erlotinib hydrochloride | 183319-69-9 | 99.9% | 10 MG
Erlotinib hydrochloride is the hydrochloride salt of erlotinib, an EGFR tyrosine kinase inhibitor used in research to study oncology, signal transduction, and inhibitor profiling. Supplied as a high-purity solid suitable for in vitro assays and formulation development.
- High purity suitable for biochemical and cell-based assays.
- Molecular weight 429.90 g/mol; formula C22H24ClN3O4.
- Soluble in DMSO (~3.33 mg/mL); in vivo formulation guidance provided by manufacturer.
- Available in small-mass packages for assay development, including 10 mg size.
- Acts as an EGFR tyrosine kinase inhibitor (IC50 ≈ 2 nM) for target validation studies.
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MM 1 ML
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. It does not induce intracellular calcium mobilization. Studies show it dose-dependently decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI), also blocking Phencyclidine (PCP)-induced deficits.
- GHSR-1a antagonist (IC50 of 32±3 nM)
- No intracellular calcium mobilization
- Dissociation constant (Kb) of 19±6 nM
- Decreases acoustic startle responses (ASR) and increases prepulse inhibition (PPI)
- Blocks PCP-induced PPI deficits
- Relevant for neurological disease and endocrinology research
- Store at 4°C (sealed, away from moisture) or in solvent at -80°C (6 months) / -20°C (1 month)
Medchemexpress LLC RS-127445 | 199864-87-4 | C17H16FN3 | 5 MG
This compound is a selective, high-affinity, and orally bioavailable antagonist of the 5-HT2B receptor, exhibiting a pKi of 9.5. It demonstrates significantly higher selectivity (1000-fold) for this receptor compared to numerous other receptor and ion channel binding sites.
- High affinity for the target receptor.
- Orally bioavailable.
- Shows high selectivity, reducing off-target effects.
- Effective in inhibiting serotonin-induced intracellular calcium increases.
- Proven antagonist activity in cellular assays.
Medchemexpress LLC Vu 0238429 | 1160247-92-6 | 99.9% | 100 MG
VU 0238429 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor subtype 5 (mAChR5, M5) used as a research tool to probe M5 receptor pharmacology.
- Positive allosteric modulator of mAChR5 with EC50 1.16 μM.
- High purity (≈99.9%), suitable for research applications.
- Solid, light yellow to orange appearance.
- Stable under recommended storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
- Relevant to GPCR/G protein and neuronal signaling studies.
Medchemexpress LLC Cp-409092 hydrochloride | 225240-86-8 | 99.8% | 333.81 g/mol | C17H20ClN3O2 | 25 MG
CP-409092 hydrochloride is a research chemical that functions as a partial agonist of the GABAA receptor and has reported anxiolytic activity. Supplied as the hydrochloride salt, it is provided as a high-purity solid for in vitro and in vivo pharmacology studies.
- Acts as a partial agonist of the GABAA receptor.
- Demonstrates reported anti-anxiety (anxiolytic) activity in pharmacological assays.
- High purity (≈99.8%) with white to off-white solid appearance.
- Soluble in water and DMSO with ultrasonic assistance for stock preparation.
- Documented with COA, SDS, and data sheet for research handling.
eMolecules 53179-07-0 | Medchem Express | Nisoxetine | 5mg | 783660599 | HY-B1704 | MFCD00865443 | 271.36 | C17H21NO2
Medchem Express | Nisoxetine | 5mg | 783660599 | HY-B1704 | 53179-07-0 | MFCD00865443 | 271.360 | C17H21NO2
Medchemexpress LLC TAK-960 dihydrochloride | 1137868-52-0 | C27H36Cl2F3N7O3 | 50 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.
- Causes accumulation of G2-M cells, aberrant polo mitosis morphology, and increased phosphorylation of histone H3 (pHH3).
- Inhibits proliferation of multiple cancer cell lines (e.g., HT-29, HCT116, HeLa) with mean EC50 values from 8.4 to 46.9 nM, not affecting normal cells.
- In HeLa cells, 8 nM leads to G2/M cell cycle arrest without significant cytotoxicity.
- In animal models, it shows substantial antitumor activity and good tolerability against HT-29 colorectal cancer xenografts.
Cayman Chemical Terbinafine hydrochloride
A broad-spectrum antifungal agent; has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml); selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively); induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and HUVECs from 90-120 μM