Hydrochlorides
![Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | 99.7% | 342.44 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | 99.7% | 342.44 | 25 MG
VU 0240551 is a potent and selective neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM, demonstrating selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. VU 0240551 has been shown to attenuate GABA-induced hyperpolarization of P cells, induce a positive shift in the P cell GABA reversal potential, and enhance P cell synaptic transmission.
- In HEK293 cells, VU 0240551 showed an IC50 of 568 nM for antagonist activity at KCC2.
- It exhibited an IC50 > 50 μM for antagonist activity at NKKC1 in human HEK293 cells.
- VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner.
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 10 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It exhibits significant selectivity over other CDK kinases and demonstrates potent anti-tumor activity.
- Potent, selective, and orally active CDK9 inhibitor
- Shows over 50-fold selectivity for CDK9/cyclin T1
- Exhibits potent anti-tumor activity
- Significantly reduces downstream phosphorylation of RNA Pol II
- Reduces global androgen receptor protein levels
- Shows cytostatic effects in prostate cancer and leukemia cell lines
- Well tolerated and reduces tumor burden in xenograft models
- Soluble in H2O and DMSO
![Medchemexpress LLC 3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride | 1197334-04-5 | 99.4% | 328.80 g/mol | C17H17ClN4O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245959.png-250.jpg)
Medchemexpress LLC 3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride | 1197334-04-5 | 99.4% | 328.80 g/mol | C17H17ClN4O | 10 MG
SB 206553 hydrochloride is the hydrochloride salt of a selective 5-HT2B/5-HT2C serotonin receptor antagonist used in pharmacological research. It is supplied as a high-purity solid for in vitro and in vivo studies and is typically provided in small milligram pack sizes.
- Selective 5-HT2B and 5-HT2C receptor antagonist.
- High purity, 99.4%.
- Hydrochloride salt form for improved solubility.
- Supplied in small pack sizes suitable for research (e.g., 5 MG, 10 MG, 25 MG).
- Recommended storage: sealed, away from moisture; solid at -20°C; in solvent, -80°C for long-term.
Medchemexpress LLC Terbinafine | 91161-71-6 | MFCD00242672 | 99.96% | 291.43 | 500 MG
Terbinafine (TDT 067) is an orally active and potent antifungal agent. It is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria. It is a click chemistry reagent that contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active.
- Potent antifungal agent.
- Potent non-competitive inhibitor of squalene epoxidase.
- Shows antibacterial activity against certain gram-positive and gram-negative bacteria.
- Click chemistry reagent.
- Contains an alkyne group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition with molecules containing azide groups.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 | C4H8ClNS | 10 MG
2-Iminothiolane hydrochloride is a thiolating reagent used to introduce sulfhydryl (-SH) groups into primary amines of proteins, peptides, and oligosaccharides. It reacts under near-physiological conditions to expose free thiols for subsequent conjugation, crosslinking, or labeling in bioconjugation workflows.
- Reacts with primary amines at pH 7-10 to generate free thiols.
- Forms an amidine linkage that tethers the thiol to the substrate.
- Enables protein and peptide modification for bioconjugation.
- Suitable for glycan labeling and oligosaccharide modification.
- High purity for reproducible experimental results (>99.9%).
- Solid, white to off-white material that is easy to handle and weigh.
- Available in small research-scale pack sizes for laboratory use.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 g·mol⁻¹ | C4H8ClNS | 500 MG
2-Iminothiolane hydrochloride is a thiolation reagent that introduces free sulfhydryl (-SH) groups into primary amines on proteins, peptides, and oligosaccharides under mild aqueous conditions (pH 7-10). It is commonly used to generate thiol handles for downstream conjugation, crosslinking, and labeling workflows where efficient coupling to thiol-reactive probes is required.
- High purity suitable for biochemical applications.
- Introduces free sulfhydryl groups to primary amines at pH 7-10.
- Enables efficient conjugation to maleimide or thiol-reactive probes.
- Reactive under mild, aqueous conditions preserving biomolecule integrity.
- Available in multiple pack sizes for scale flexibility.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 g·mol⁻¹ | C4H8ClNS | 250 MG
2-Iminothiolane hydrochloride is a thiolating reagent (Traut's reagent) used to introduce sulfhydryl (-SH) groups into primary amines on proteins, peptides, and oligosaccharides for bioconjugation, labeling, and cross-linking. It reacts efficiently near neutral to slightly alkaline pH to form thiol-modified biomolecules while minimizing disruption of native structure.
- Reacts with primary amines at pH 7-10 to generate free sulfhydryl groups.
- Suitable for protein, peptide, and oligosaccharide modification for bioconjugation.
- High purity (≈99.9%) for reliable, reproducible results.
- Soluble in water (100 mg/mL) and DMSO (14.29 mg/mL) with ultrasonic or gentle warming as needed.
- Recommended storage sealed at 4°C; prepared solutions stable at -20°C (short term) or -80°C (long term) per datasheet.