Hydrochlorides
Medchemexpress LLC Efaroxan hydrochloride | 89197-00-2 | 99.80% | 25 MG
Efaroxan hydrochloride is a potent, selective, and orally active α2-adrenoceptor antagonist, demonstrating antidiabetic activity. It also acts as a selective I1-Imidazoline receptor antagonist. This compound can be utilized in research related to cardiovascular disease.
- Potent, selective, and orally active α2-adrenoceptor antagonist.
- Possesses antidiabetic activity.
- Selective I1-Imidazoline receptor antagonist.
- Applicable for research in cardiovascular disease.
- Binds to I1-imidazoline and α2-adrenergic receptors with Kᵢ values of 0.15 nM and 5.6 nM, respectively, in bovine rostral ventrolateral medulla membranes.
- Increases plasma insulin levels in conscious fed and fasted rats without significantly affecting plasma glucose levels.
Cayman Chemical Teijin Compound 1 hydrochlor
A CCR2b antagonist (IC50 = 180 nM in a radioligand binding assay); inhibits CCL2-induced chemotaxis in THP-1 cells (EC50 = 24 nM)
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 100.0% | 591.23 | 10 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It has IC50s of 8.9 nM for rat uterus oxytocin receptor and 26 nM for human uterus oxytocin receptor. It is used as a tocolytic agent.
- Potent oxytocin receptor antagonist
- Selective action
- Orally bioavailable
- Non-peptide structure
- IC50s of 8.9 nM for rat uterus oxytocin receptor and 26 nM for human uterus oxytocin receptor
- Used as a tocolytic agent
- Soluble in DMSO (100 mg/mL)
- Soluble in H2O (5 mg/mL)
- Storage at 4°C sealed, away from moisture
- In solvent storage at -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC PB28 dihydrochloride | 172907-03-8 | 99.6% | 443.49 | 10 MG
PB28 dihydrochloride is a high-affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM, also acting as a σ1 antagonist with a Ki of 0.38 nM. This cyclohexylpiperazine derivative inhibits electrically evoked twitch in guinea pig bladder and ileum, and can modulate SARS-CoV-2-human protein-protein interaction. It induces caspase-independent apoptosis and exhibits antitumor activity. This product is for research use only.
- High-affinity and selective sigma 2 (σ2) receptor agonist
- Sigma 1 antagonist
- Inhibits electrically evoked twitch in guinea pig bladder and ileum
- Modulates SARS-CoV-2-human protein-protein interaction
- Induces caspase-independent apoptosis
- Exhibits antitumor activity
Medchemexpress LLC Queuine dihydrochloride | 86496-18-6 | 350.20 | 50 MG
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT), incorporated into eukaryotic tRNA to promote modification. Its deficiency enhances aerobic glycolysis, inhibits oxidative phosphorylation, and promotes Warburg metabolism. It is useful for autoimmune diseases and cancer metabolic regulation and is for research use only.
- Selective substrate for tRNA guanine transglycosylase.
- Promotes tRNA modification in eukaryotic cells.
- Impacts mitochondrial function and Warburg metabolism.
- Deficiency linked to enhanced glycolysis and inhibited oxidative phosphorylation.
- Potential for autoimmune disease and cancer metabolic research.
- Reduces lactate dehydrogenase activity and lactate production.
- Natural TGT substrate, replacing guanine (G34) in tRNA.
Medchemexpress LLC Anabasine ((S)-Anabasine) | 494-52-0 | 99.0% | 25 MG
Anabasine ((S)-Anabasine) is an alkaloid found as a minor component in tobacco (Nicotiana). It is a botanical pesticide, nicotine, and acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 μM).
- Alkaloid found in tobacco
- Botanical pesticide
- Full agonist of nicotinic acetylcholine receptors (nAChRs)
- Induces depolarization of TE671 cells
Medchemexpress LLC Dapoxetine hydrochloride | 129938-20-1 | 99.96% | 50 MG
Dapoxetine hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) used for premature ejaculation (PE) research. It binds to 5-HT, norepinephrine, and dopamine reuptake transporters.
- Inhibits 5-HT, norepinephrine, and dopamine uptake
- Can be used for premature ejaculation (PE) research
- Oral gavage significantly inhibits testosterone-mediated increase in prostate weight in rats
Medchemexpress LLC Nisoxetine hydrochloride | 57754-86-6 | 99.9% | 25 MG
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It is an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Functions as an antidepressant
- Acts as a local anesthetic
- Blocks voltage-gated sodium channels
Chem-Impex International, Inc. 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 10G
2-Iminothiolane hydrochloride, 4781-83-3, MFCD00039013, 10G
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 99.9% | 591.23 | 25 MG
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist. It is used as a tocolytic agent and shows less activity on VP receptors in human and rat liver and kidney.
- Potent, orally bioavailable, non-peptide oxytocin receptor antagonist
- IC50s of 8.9 nM for rat uterus oxytocin receptor
- IC50s of 26 nM for human uterus oxytocin receptor
- Used as a tocolytic agent
- Less active on VP receptor in human and rat liver and kidney
- Exhibits similar pharmacokinetics in rats and dogs
- Orally available with demonstrated bioavailability in rats
Medchemexpress LLC RS-25344 hydrochloride | 152815-28-6 | 99.9% | 411.80 | 25 MG
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. It has only weak inhibitory effects on PDE I, II, and III (IC50 of >100 μM, 160 μM, and 330 μM, respectively). It exhibits anti-inflammatory, memory- and cognition-enhancing, and antineoplastic effects. It is a potent inhibitor of sperm PDE activity, with an effective concentration of 0.3 nM, reaching maximum inhibition in the range of 100 nM. In vivo studies have shown that it can significantly increase stomach weights and gastric retention in mice.
- Selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor.
- Exhibits anti-inflammatory effects.
- Enhances memory and cognition.
- Possesses antineoplastic effects.
- Potent inhibitor of sperm PDE activity.
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 | 25 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist. It demonstrates high selectivity with EC50s of 0.028 μM for OX2R and 2.75 μM for OX1R. This compound has been shown to ameliorate narcolepsy-cataplexy symptoms in mouse models, increasing wakefulness and decreasing NREM sleep time.
- Selective orexin type-2 receptor (OX2R) agonist
- Nonpeptide compound
- EC50 of 0.028 μM for OX2R
- Ameliorates narcolepsy-cataplexy symptoms in mouse models
- Increases wakefulness
- Decreases NREM sleep time