Hydrochlorides
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 1 ML
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15 nM, 21 nM, and 15 nM, respectively, and induces apoptosis. It inhibits cell viability in cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells. It also downregulates cIAP-1, activates RIPK1 (upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7.
- Antagonist of inhibitor of apoptosis proteins (IAPs).
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP.
- Induces apoptosis.
- Inhibits cell viability in NSCLC cells.
- Downregulates cIAP-1 and activates RIPK1.
- Triggers extrinsic and intrinsic apoptosis pathways.
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.77% | 360.33 | 25 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It shows >50-fold selectivity over other CDK kinases and exhibits potent anti-tumor activity.
- Potent and selective CDK9 inhibitor.
- Orally active.
- Exhibits >50-fold selectivity over other CDK kinases.
- Possesses potent anti-tumor activity.
- Reduces downstream phosphorylation of RNA Pol II.
- Downregulates global androgen receptor (AR) protein levels.
- Decreases nascent transcription and depletes short half-life transcripts.
- Well tolerated and significantly reduces tumor burden in xenograft models.
Medchemexpress LLC preQ1 dihydrochlorid 10mg | 86694-45-3 | 252.10 | C7H11Cl2N5O | 10 MG
preQ1 dihydrochloride is a guanine-derived nucleobase used as a precursor in the biosynthesis of queuine and as a ligand for PreQ1 riboswitch studies. Supplied as the dihydrochloride salt for research use, the compound has defined solubility and storage recommendations.
- Precursor in queuine biosynthesis and useful for tRNA modification studies.
- Binds the PreQ1 riboswitch aptamer with high affinity.
- Solubility: DMSO 125 mg/mL; water 15 mg/mL (may require ultrasonic agitation).
- Solid storage recommended at 4°C in a sealed container, protected from moisture and light.
- In-solution stability: store at -80°C for up to 6 months or -20°C for up to 1 month when sealed.
Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 50 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes.
- Positive and highly selective mGlu5R allosteric modulator
- EC50 of 33 nM for mGlu5R
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Appearance: solid, white to off-white
- Solubility in DMSO: ≥ 50 mg/mL (163.76 mM)
Medchemexpress LLC SB 202190 hydrochloride | 350228-36-3 | MFCD17215958 | 99.7% | 367.80 g·mol⁻1 | C20H15ClFN3O | 50 MG
SB 202190 hydrochloride is the hydrochloride salt of a selective p38 mitogen-activated protein kinase (MAPK) inhibitor used in biochemical and cellular research to probe p38 signaling pathways. It is supplied as a solid and as a ready-to-use DMSO solution, and is characterized by high purity and defined storage recommendations.
- Selective inhibitor of p38 MAPK isoforms.
- High purity suitable for research applications.
- Available as solid and as a 10 mM solution in DMSO.
- Light yellow solid appearance for easy visual inspection.
- Requires low-temperature, sealed storage to preserve stability.