Hydrochlorides
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 50 MG
KB-0742 dihydrochloride is a potent, selective, and orally active inhibitor of CDK9/cyclin T1, demonstrating an IC50 of 6 nM. It exhibits over 50-fold selectivity against other CDK kinases and shows significant anti-tumor activity. This compound has been shown to reduce downstream phosphorylation of RNA Pol II at Ser2, Ser7, and Ser5, and to diminish global androgen receptor protein levels in prostate cancer cells. It also displays antiproliferative effects in various cancer cell lines, such as prostate cancer and leukemia.
- Potent and selective CDK9 inhibitor.
- Orally active with significant anti-tumor efficacy.
- Exhibits high selectivity for CDK9/cyclin T1 over other CDK kinases.
- Induces significant reduction of RNA Pol II phosphorylation.
- Demonstrates antiproliferative activity in cancer cell lines.
Medchemexpress LLC DPTN dihydrochloride | 325767-87-1 | C22H20Cl2N4OS | 5 MG
DPTN dihydrochloride is a potent and selective human, mouse, and rat A3AR antagonist. It exhibits Ki values of 1.65 nM for human A3AR, 9.61 nM for mouse A3AR, and 8.53 nM for rat A3AR. This product is for research use only.
- Potent and selective A3AR antagonist
- High purity (98.47%)
- Solid appearance
- Light yellow to yellow color
- Store at -20°C, sealed, away from moisture
- Shipped at room temperature in continental US
Medchemexpress LLC DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG
DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 1 ML
Verubulin hydrochloride is the hydrochloride salt of verubulin (MPC-6827), a microtubule/tubulin inhibitor used in preclinical research. It is supplied as a ready-to-use 10 mM solution in DMSO and is also available as solid quantities for custom preparation. Intended for research use only.
- Highly pure product (98.7% typical).
- Provided as 10 mM, 1 mL solution in DMSO for ready-to-use applications.
- Available as solid in multiple masses (mg scale) for flexible dosing.
- Molecular weight 315.8 g/mol; formula C17H18ClN3O.
- Suitable for in vitro and in vivo preclinical research; not for human use.
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | 99.9% | 495.07 | 5 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. It induces proliferation and migration on endothelial cells by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding to the receptor
- Possesses antithrombotic activity
- Induces proliferation and migration on endothelial cells
- Significantly reduces myocardial no-reflow
- Alleviates myocardial microvascular structural and endothelial dysfunction
Medchemexpress LLC AQ-13 dihydrochloride | 169815-40-1 | MFCD28469800 | 98.1% | 364.74 g/mol | C16H24Cl3N3 | 1 ML
AQ-13 dihydrochloride is an aminoquinoline antimalarial compound active against drug-resistant strains of Plasmodium falciparum. Supplied in ready-to-use solution and solid forms, it is intended for in vitro antiparasitic research and related biochemical studies.
- Aminoquinoline antimalarial active against drug-resistant Plasmodium falciparum.
- Available as a 10 mM solution in DMSO and as solid quantities.
- High purity, approximately 98.1%.
- Molecular formula C16H24Cl3N3; molecular weight 364.74 g/mol.
- Includes CAS number 169815-40-1 for unambiguous identification.
- Recommended storage: sealed at 4°C; stock solutions, -80°C (6 months) or -20°C (1 month).
- Intended for in vitro antiparasitic and biochemical research applications.
Cayman Chemical DoxepIn N-oxIdehydrate 10mg
A metabolite of doxepin; a photodegradation product of doxepin
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 | C11H17ClN2O3 | 50 MG
Nifenalol hydrochloride is the hydrochloride salt of a β-adrenergic receptor antagonist used in cardiovascular and receptor pharmacology research. It is provided as a high-purity solid reagent with supporting analytical documentation for laboratory use.
- High purity for reliable experimental results.
- Hydrochloride salt, stable solid form for storage and handling.
- Suitable for in vitro adrenergic receptor assays and cardiovascular studies.
- Certificate of analysis and safety data sheet available for quality and safety documentation.
- Available in small research pack sizes for laboratory workflows.
![Medchemexpress LLC (S)-9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoind | 2092923-21-0 | 99.5% | 438.85 | C24H17ClF2N2O2 | 10 MM 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211664.png-250.jpg)
Medchemexpress LLC (S)-9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoind | 2092923-21-0 | 99.5% | 438.85 | C24H17ClF2N2O2 | 10 MM 1 ML
VU 6008667 is a selective negative allosteric modulator of the muscarinic acetylcholine receptor M5. It inhibits human M5 and rat M5 with IC50 values of 1.2 μM and 1.6 μM, respectively, and is supplied for research use only as a 10 mM solution in DMSO (1 mL); solid quantities are also available. Reported data indicate high central nervous system penetration.
- Selective M5 negative allosteric modulator with documented IC50 values.
- High central nervous system penetration suitable for CNS studies.
- Provided as a ready-to-use 10 mM solution in DMSO (1 mL).
- High purity with supporting analytical documentation (COA, HPLC, MS).
- Intended for research use only; not for clinical or therapeutic use.
Medchemexpress LLC 2-Buten-1-amine, 3-fluoro-4-(phenylsulfonyl)-, hydrochloride (1:1), (2Z)- | 2409964-40-3 | C10H13ClFNO2S | 25 MG
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor, abolishing lysyl oxidase activity. It inhibits LOX with IC50s ranging from 0.2 μM to 3.2 μM across various LOX isoforms, and also reduces deposition and crosslinking of collagen I secreted by human fibroblasts.
- Purity of 99.71%
- Solid, white to off-white appearance
- Molecular weight of 265.73
- Storage conditions: 4°C sealed for solid; -80°C for 6 months or -20°C for 1 month in solvent
- Soluble in DMSO at 100 mg/mL
- Inhibits LOX isoforms including Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4
- Reduces collagen I deposition and crosslinking
Medchemexpress LLC SB-399885 hydrochloride | 402713-81-9 | 98.3% | 482.81 g/mol | C18H22Cl3N3O4S | 10 MG
SB-399885 hydrochloride is a research-grade small molecule hydrochloride salt that acts as a selective 5-HT6 (serotonin) receptor antagonist. It is supplied as a solid for laboratory research, suitable for in vitro and in vivo pharmacology and behavioral studies. CAS 402713-81-9; molecular weight 482.81 g/mol.
- High purity suitable for research use.
- Hydrochloride salt form for improved solubility.
- Applicable to in vitro receptor pharmacology and in vivo behavioral assays.
- Supplied with a supplier datasheet for handling and storage information.
- Available in small bench-scale pack sizes for preclinical studies.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 | C14H22Cl2N2 | 10 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with an IC50 of 16 nM. Provided as a solid for research use, the compound has been used in cellular studies to modulate gene expression, induce autophagy markers, and inhibit proliferation in various cancer cell lines. Handle and store according to safety data sheet recommendations.
Medchemexpress LLC Ly-272015 hydrochloride | 172895-15-7 | MFCD00933882 | 99.5% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
LY-272015 hydrochloride is the hydrochloride salt of LY-272015, a selective, orally active 5-HT2B receptor antagonist. It blocks 5-HT or BW723C86-induced ERK2 phosphorylation and has demonstrated antihypertensive activity in DOCA-salt hypertensive rat models. Supplied as a high-purity off-white to light-yellow solid for research use.
- Selective 5-HT2B receptor antagonist.
- Orally active compound suitable for in vivo studies.
- Inhibits 5-HT or BW723C86-induced ERK2 phosphorylation.
- Demonstrated antihypertensive effects in DOCA-salt hypertensive rats.
- High reported purity (99.5%).
- Soluble in DMSO at 5 mg/mL with ultrasonic assistance.
![Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244527.png-250.jpg)
Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.
- Selective positive allosteric modulation of mAChR M5.
- EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
- Enhances acetylcholine-stimulated insulin secretion in human β-cells.
- Available as solid or as a 10 mM solution in DMSO for flexible application.
- High purity suitable for biochemical and cellular assays.
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 500 MG
Azaphen dihydrochloride monohydrate, also known as Pipofezine or Azafen, is a potent inhibitor of serotonin reuptake. It functions as a tricyclic antidepressant (TCA) and is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Acts as a tricyclic antidepressant
- Used for the treatment of depression