Hydrochlorides
Medchemexpress LLC Nisoxetine hydrochloride | 57754-86-6 | MFCD00078426 | 99.92% | 5 MG
Nisoxetine hydrochloride is a potent and selective inhibitor of the noradrenaline transporter (NET), with a Kd of 0.76 nM. It functions as an antidepressant and local anesthetic by blocking voltage-gated sodium channels.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Acts as an antidepressant
- Functions as a local anesthetic
- Blocks voltage-gated sodium channels
eMolecules 21987-29-1 | 4,4-DIFLUOROPIPERIDINE | AstaTech | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 5g | 261434923
4,4-DIFLUOROPIPERIDINE | AstaTech | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 5g | 261434923
eMolecules 21987-29-1 | 4,4-DIFLUOROPIPERIDINE | AstaTech | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 1g | 261434922
4,4-DIFLUOROPIPERIDINE | AstaTech | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 1g | 261434922
C1 | 1g | 603145005](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502193564.JPG-250.jpg)
eMolecules 1286208-55-6 | (R)-1-(3-Aminopyrrolidin-1-yl)ethanone hydrochloride | Combi-Blocks, Inc. | MFCD17014273 | 164.630 | C6H13ClN2O | 95.000 | Cl.CC(=O)N1CC[C@@H](N)C1 | 1g | 603145005
(R)-1-(3-Aminopyrrolidin-1-yl)ethanone hydrochloride | Combi-Blocks, Inc. | 1286208-55-6 | MFCD17014273 | 164.630 | C6H13ClN2O | 95.000 | Cl.CC(=O)N1CC[C@@H](N)C1 | 1g | 603145005
eMolecules 89990-54-5 | Pyrazolidine dihydrochloride | A1 Biochem Labs | MFCD16620353 | 145.030 | C3H10Cl2N2 | 95.000 | Cl.Cl.C1CNNC1 | 1g | 283328635
Pyrazolidine dihydrochloride | A1 Biochem Labs | 89990-54-5 | MFCD16620353 | 145.030 | C3H10Cl2N2 | 95.000 | Cl.Cl.C1CNNC1 | 1g | 283328635
eMolecules 6291-01-6 | Cyclobutanamine hydrochloride | ChemScene | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 10g | 536772988
Cyclobutanamine hydrochloride | ChemScene | 6291-01-6 | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 10g | 536772988
Medchemexpress LLC Melflufen (hydrochloride) | 380449-54-7 | 98.1% | 534.88 | C24H31Cl3FN3O3 | 25 MG
Melflufen hydrochloride is a peptide-conjugated alkylating prodrug of melphalan supplied as a hydrochloride salt for research use. It demonstrates antitumor activity in preclinical studies, is provided as a high-purity solid for in vitro and biochemical oncology research, and should be handled according to the manufacturer safety data sheet.
- Peptide-conjugated alkylating prodrug.
- Demonstrates antitumor activity against multiple myeloma cells.
- Off-white to light yellow solid appearance.
- Purity approximately 98.06%.
- Molecular weight 534.88 g/mol.
- Available in small milligram pack sizes for research use.
- Store sealed at 4°C and protect from moisture; follow SDS for details.
eMolecules 89990-54-5 | Pyrazolidine dihydrochloride | Combi-Blocks | MFCD16620353 | 145.030 | C3H10Cl2N2 | 96.000 | Cl.Cl.C1CNNC1 | 1g | 457917116
Pyrazolidine dihydrochloride | Combi-Blocks | 89990-54-5 | MFCD16620353 | 145.030 | C3H10Cl2N2 | 96.000 | Cl.Cl.C1CNNC1 | 1g | 457917116
Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 10 MG
XE991 dihydrochloride is a Kv7 (KCNQ) channel blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current.
- Potently inhibits Kv7.1 (KCNQ1) channels with an IC50 of 0.75 μM.
- Inhibits Kv7.2 (KCNQ2) channels with an IC50 of 0.71 μM.
- Blocks Kv7.2 + Kv7.3 (KCNQ3) channels with an IC50 of 0.6 μM.
- Inhibits M-current with an IC50 of 0.98 μM.
- Enhances [3H]ACh release from rat brain slices with an EC50 of 490 nM.
- Demonstrates good in vivo potency and duration of action.
Medchemexpress LLC JAK-IN-5 hydrochloride | 2751323-21-2 | 99.5% | 511.03 | 25 MG
JAK-IN-5 hydrochloride is an inhibitor of JAK that was extracted from patent US20170121327A1, specifically as compound example 283. It has been shown to inhibit STAT6 phosphorylation by 60% in IL-13-induced lung tissue in a mouse model of pSTAT6 induction. Additionally, in a male C57 mouse model of Alternaria alternata-induced eosinophilic inflammation of the lung, JAK-IN-5 hydrochloride inhibited 88% of BALF eosinophils.
- Inhibitor of JAK.
- Inhibits STAT6 phosphorylation in a mouse model.
- Reduces BALF eosinophils in a mouse model of inflammation.
- For research use only.
Medchemexpress LLC N-(1,3-diphenylpyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g·mol⁻¹ | C22H16N4O3 | 100 MG
VU-29 is a small-molecule positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5), used in pharmacology and neuroscience research to potentiate receptor responses. It is characterized by low-nanomolar activity and high reported purity, and is provided as a solid appropriate for in vitro receptor modulation studies.
- Positive allosteric modulation of mGlu5 receptor (EC50 ≈ 9 nM).
- Selective activity with reported Ki ≈ 244 nM for rmGluR5.
- High reported purity suitable for research applications.
- Available in multiple package sizes for experimental flexibility.
- Small molecule with formula C22H16N4O3 and molecular weight 384.39 g·mol⁻¹.
![Medchemexpress LLC N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233838.png-250.jpg)
Medchemexpress LLC N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG
N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride | 257639-98-8 | 99.8% | 5MG
Apexbio Technology LLC VU 0361737 1161205-04-4 50mg
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease
Medchemexpress LLC (±)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride | 62717-42-4 | MFCD00069248 | 99.5% | 291.77 | C16H18ClNO2 | 100MG
SKF 38393 hydrochloride is a selective dopamine D1 receptor agonist for research use that activates D1-mediated signaling, increases intracellular cAMP, and is used in cell signaling and in vivo pharmacology studies.
- Selective D1 receptor agonist with reported IC50 of 110 nM.
- High purity (99.49%).
- CAS number 62717-42-4 for unambiguous identification.
- Molecular formula C16H18ClNO2; molecular weight 291.77 Da.
- Suitable for in vitro receptor activation and in vivo pharmacology models.
- Storage: solid at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC A-674563 hydrochloride | 2070009-66-2 | 99.9% | C22H23ClN4O | 10MG
A-674563 hydrochloride is a potent, selective Akt1 (protein kinase B) inhibitor with a reported Ki of 11 nM. It shows in vitro anti-proliferative and pro-apoptotic activity across multiple cancer cell lines and has been used in vivo to investigate Akt-dependent signaling and combination therapies.
- Potent Akt1 inhibition (Ki ≈11 nM).
- High purity suitable for research use (≈99.9%).
- Demonstrated antiproliferative activity in tumor cell assays (EC50 ≈0.4 μM).
- Effective in in vivo models for studying Akt signaling and combination regimens.
- Available as solid and DMSO solution formats for flexible dosing.