Hydrochlorides
![Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.
- Acts as a mGlu4 positive allosteric modulator
- Has an EC50 of 19.8 nM
- Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
- Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)
Medchemexpress LLC K-604 dihydrochloride | 217094-32-1 | MFCD30738203 | >=98.0% | 575.64 | C23H32Cl2N6OS3 | 25 MG
K-604 dihydrochloride is a research reagent that selectively inhibits acyl-CoA:cholesterol acyltransferase 1 (ACAT-1), with a reported IC50 of 0.45 ± 0.06 μM. Supplied as the dihydrochloride salt, it is intended for biochemical and cellular studies probing ACAT-1 activity and cholesterol esterification pathways.
- Selective ACAT-1 inhibitor with reported IC50 of 0.45 ± 0.06 μM.
- Dihydrochloride salt form for improved solubility in polar solvents.
- Molecular weight 575.64 g/mol and formula C23H32Cl2N6OS3.
- Purity reported as ≥98% by HPLC in supplier and database listings.
- CAS number 217094-32-1 for unambiguous identification.
- Suitable for biochemical and cellular assays targeting cholesterol metabolism.
Medchemexpress LLC SKF-96365 hydrochlor 50mg
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
![Medchemexpress LLC (S)-9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoind | 2092923-21-0 | 99.5% | 438.85 | C24H17ClF2N2O2 | 10 MM 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211664.png-250.jpg)
Medchemexpress LLC (S)-9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoind | 2092923-21-0 | 99.5% | 438.85 | C24H17ClF2N2O2 | 10 MM 1 ML
VU 6008667 is a selective negative allosteric modulator of the muscarinic acetylcholine receptor M5. It inhibits human M5 and rat M5 with IC50 values of 1.2 μM and 1.6 μM, respectively, and is supplied for research use only as a 10 mM solution in DMSO (1 mL); solid quantities are also available. Reported data indicate high central nervous system penetration.
- Selective M5 negative allosteric modulator with documented IC50 values.
- High central nervous system penetration suitable for CNS studies.
- Provided as a ready-to-use 10 mM solution in DMSO (1 mL).
- High purity with supporting analytical documentation (COA, HPLC, MS).
- Intended for research use only; not for clinical or therapeutic use.
Medchemexpress LLC Duloxetine metabolite Para-Naphthol Duloxetine | 949095-98-1 | 297.41 | 250 MG
Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).
- Synonym: Para-naphthol duloxetine
- CAS number: 949095-98-1
- Molecular weight: 297.41
- Molecular formula: C18H19NOS
- Appearance: Solid
- Color: White to off-white
- Storage for powder: -20°C for 3 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC Nifenalol hydrochloride | 5704-60-9 | 99.9% | 260.72 | C11H17ClN2O3 | 25 MG
Nifenalol hydrochloride is a β-adrenergic receptor antagonist supplied as a white to off-white solid for research use. It is used in pharmacology and cardiac electrophysiology studies, including investigation of early afterdepolarization (EAD) effects. The compound is provided in milligram-scale packs and has manufacturer guidance for solid and solution storage.
- β-adrenergic receptor antagonist for pharmacological research.
- Useful for studying cardiac electrophysiology and EAD mechanisms.
- High reported purity suitable for laboratory assays (99.9%).
- White to off-white solid, stable under recommended storage.
- Available in milligram-scale pack sizes for small-scale experiments.
Medchemexpress LLC PD 128907 hydrochloride | 112960-16-4 | MFCD01529976 | 99.5% | 285.77 | C14H20ClNO3 | 25 MG
PD 128907 hydrochloride is a potent and selective dopamine D3 receptor agonist supplied as a solid biochemical reagent for life-science research. It is used in pharmacology and neurobiology to probe D3-mediated signaling and dopaminergic mechanisms, and is provided at high purity in small pack sizes for laboratory experiments.
- Potent D3 receptor agonist with low-nanomolar activity.
- High selectivity over D2 receptors for receptor-specific studies.
- High purity suitable for research applications.
- Solid form with white to light yellow appearance.
- Available in multiple small pack sizes for dosing flexibility.
- Recommended sealed storage away from moisture to preserve stability.
Medchemexpress LLC TAK-960 dihydrochloride | 99.2% | 634.52 | 5 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also demonstrates inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and shows significant efficacy against various tumor xenografts.
- Orally available
- Selective inhibitor of polo-like kinase 1 (PLK1)
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against various tumor xenografts
- Causes accumulation of G2-M cells
- Leads to G2/M cell cycle arrest
Medchemexpress LLC BAY-6672 hydrochloride | 2247520-31-4 | C26H28BrCl2N3O3 | 1 ML
BAY-6672 hydrochloride is a chemical compound supplied as a solid, primarily intended for laboratory research and the manufacture of substances.
- Identified for laboratory chemical applications
- Recommended storage at 4°C under nitrogen, away from moisture
- Store in solvent at -80°C for 6 months or -20°C for 1 month, under nitrogen
- Ships at room temperature if transit is less than 2 weeks
- For research use only
Medchemexpress LLC Benzenepropanoic acid, ß-(aminomethyl)-4-chloro-, hydrochloride (1:1) | 28311-31-1 | 99.8% | C10H13Cl2NO2 | 1 ML
Baclofen hydrochloride is a lipophilic derivative of γ-aminobutyric acid (GABA) and an orally active, selective metabotropic GABAB receptor (GABABR) agonist. It mimics the action of GABA, producing slow presynaptic inhibition through the GABAB receptor. This compound exhibits high blood-brain barrier penetrance, making it suitable for muscle spasticity research.
- Orally active, selective GABAB receptor agonist.
- Mimics GABA action for slow presynaptic inhibition.
- Exhibits high blood-brain barrier penetrance.
- Increases cell viability in huntingtin-expressing striatal cells.
- Enhances chymotrypsin-like proteasome activity.
- Ameliorates motor deficits in Huntington's disease animal models.
- Reduces neuronal intranuclear inclusions in animal models.
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | MFCD07368623 | 99.9% | 495.07 g/mol | C22H39ClN2O6S | 10 MG
Tirofiban hydrochloride monohydrate is the hydrochloride monohydrate salt of tirofiban, a selective and reversible platelet integrin (Gp IIb/IIIa) antagonist supplied for research and analytical applications. It inhibits fibrinogen binding to the Gp IIb/IIIa receptor and is provided as a high-purity solid suitable for in vitro studies.
- Selective, reversible Gp IIb/IIIa antagonist suitable for platelet research.
- Inhibits fibrinogen binding to the Gp IIb/IIIa receptor.
- High purity (≈99.9%) for reproducible experimental results.
- Available in small laboratory quantities for analytical and preparative use.
- Supplied as a stable hydrochloride monohydrate salt for consistent handling.
Medchemexpress LLC ENMD-1068 hydrochloride | 2703451-51-6 | 98.3% | 319.87 | C15H30ClN3O2 | 10MM 1ML
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist used in biochemical and cellular research to probe PAR2 signaling and related pathways such as TGF-β1/Smad. The compound is supplied as the hydrochloride salt with high reported purity and is offered both as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid pack sizes for flexibility in experimental workflows.
- Selective PAR2 antagonist suitable for signaling and fibrosis research.
- Provided as the hydrochloride salt with white to off-white appearance.
- Available as a 10 mM DMSO solution (1 mL) for immediate use in assays.
- Offered in solid quantities for custom formulation and dosing.
- High reported purity (~98.3%) and defined molecular weight for reliable dosing.
- Solubility data and storage recommendations provided for in vitro and in vivo use.
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Medchemexpress LLC SB-258585 hydrochloride | 1216468-02-8 | 99.7% | 523.82 g/mol | C18H23ClIN3O3S | 10 MG
SB-258585 hydrochloride is a research compound used as a high-affinity ligand and antagonist for the serotonin 5-HT6 receptor (CAS 1216468-02-8). Supplied as the hydrochloride salt, it has molecular formula C18H23ClIN3O3S, molecular weight 523.82 g/mol, and is provided for in vitro and ex vivo pharmacological and receptor-binding studies.
- High-affinity antagonist of the serotonin 5-HT6 receptor.
- High reported purity, suitable for analytical and biological assays.
- Appropriate for radioligand binding and receptor labeling studies.
- Supplied in small-mass research quantities for laboratory use.
- Molecular weight 523.82 g/mol and defined molecular formula.
Medchemexpress LLC TG 100572 hydrochloride | 867331-64-4 | MFCD18251422 | 98.8% | 512.43 g/mol | C26H27Cl2N5O2 | 50 MG
TG 100572 Hydrochloride is a multi-targeted kinase inhibitor supplied as a hydrochloride salt for laboratory research. It inhibits several receptor tyrosine kinases and Src family kinases and is used in vitro to study signaling pathways and kinase-dependent cellular processes. Offered in multiple pack sizes with high listed purity for biochemical and cell-based studies.
- Multi-targeted kinase inhibition profile (VEGFR, FGFR, PDGFR, Src family).
- High listed purity suitable for in vitro assays.
- Available in small pack sizes and solution format for flexibility.
- Compatible with biochemical and cell-based assay workflows.
- For research use only; not for human or veterinary use.