Hydrochlorides
Medchemexpress LLC SB-399885 hydrochloride | 402713-81-9 | 98.3% | 482.81 g/mol | C18H22Cl3N3O4S | 10 MG
SB-399885 hydrochloride is a research-grade small molecule hydrochloride salt that acts as a selective 5-HT6 (serotonin) receptor antagonist. It is supplied as a solid for laboratory research, suitable for in vitro and in vivo pharmacology and behavioral studies. CAS 402713-81-9; molecular weight 482.81 g/mol.
- High purity suitable for research use.
- Hydrochloride salt form for improved solubility.
- Applicable to in vitro receptor pharmacology and in vivo behavioral assays.
- Supplied with a supplier datasheet for handling and storage information.
- Available in small bench-scale pack sizes for preclinical studies.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 | C14H22Cl2N2 | 10 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with an IC50 of 16 nM. Provided as a solid for research use, the compound has been used in cellular studies to modulate gene expression, induce autophagy markers, and inhibit proliferation in various cancer cell lines. Handle and store according to safety data sheet recommendations.
Chem-Impex International, Inc. O-Benzyl-hydroxylamine hydrochloride | 2687-43-6 | MFCD00012952 | 5G
O-Benzyl-hydroxylamine hydrochloride, 2687-43-6, MFCD00012952, 5G
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 1 ML
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15 nM, 21 nM, and 15 nM, respectively, and induces apoptosis. It inhibits cell viability in cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells. It also downregulates cIAP-1, activates RIPK1 (upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7.
- Antagonist of inhibitor of apoptosis proteins (IAPs).
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP.
- Induces apoptosis.
- Inhibits cell viability in NSCLC cells.
- Downregulates cIAP-1 and activates RIPK1.
- Triggers extrinsic and intrinsic apoptosis pathways.
Medchemexpress LLC Naloxone hydrochloride | 357-08-4 | 100.0% | 363.84 | 100 MG
Naloxone hydrochloride is an antagonist of the Opioid receptor. It alleviates respiratory depression induced by opioid overdose, though it may also cause pulmonary edema and cardiac arrhythmias. It is intended for research use only and not for sale to patients.
- Opioid receptor antagonist
- Alleviates opioid-overdose-induced respiratory depression
- Data sheet, COA, SDS, and handling instructions provided
- Soluble in H2O (62.5 mg/mL) and DMSO (≥ 30 mg/mL)
Apexbio Technology LLC VU 0155069 1130067-06-9 50mg
VU 0155069 (CAS 1130067-06-9) is a selective inhibitor of phospholipase D1 (PLD1) with an IC50 of 46 nM PLD1 regulates the production of phosphatidic acid a lipid mediator involved in signal transduction by G protein-coupled and receptor tyrosine kinases At 200 nM VU 0155069 preferentially inhibits PLD1 activity over PLD2 evidenced by decreased PLD1-driven migration in 4T1 cells At higher concentrations (20 M) it inhibits both PLD isoforms in Calu-1 and HEK293-gfpPLD2 cells In hepatocellular carcinoma xenograft models VU 0155069 administration significantly reduced tumor size and proliferation markers This compound is valuable for investigating PLD1-mediated cellular processes and cancer progression
Medchemexpress LLC SB 202190 hydrochloride | 350228-36-3 | MFCD28391789 | 99.7% | 367.80 g·mol⁻¹ | C20H15ClF3NO | 1 ML
SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor used in cell signaling and pharmacology research. It is commonly supplied in concentrated stock formats for convenient preparation of working solutions.
- Selective p38 MAPK inhibitor; p38α IC50 ≈ 50 nM, p38β2 IC50 ≈ 100 nM.
- Supplied in a 10 mM solution format (1 mL) for ready stock preparation.
- Molecular weight 367.80 g·mol⁻¹; formula C20H15ClF3NO.
- DMSO-soluble; may require sonication and warming (up to 60°C) for full dissolution.
- Storage in solvent: -80°C (up to 6 months) or -20°C (up to 1 month); keep sealed and dry.
- High purity (manufacturer reported ~99.7%) suitable for research applications.
Medchemexpress LLC preQ1 dihydrochlorid 10mg | 86694-45-3 | 252.10 | C7H11Cl2N5O | 10 MG
preQ1 dihydrochloride is a guanine-derived nucleobase used as a precursor in the biosynthesis of queuine and as a ligand for PreQ1 riboswitch studies. Supplied as the dihydrochloride salt for research use, the compound has defined solubility and storage recommendations.
- Precursor in queuine biosynthesis and useful for tRNA modification studies.
- Binds the PreQ1 riboswitch aptamer with high affinity.
- Solubility: DMSO 125 mg/mL; water 15 mg/mL (may require ultrasonic agitation).
- Solid storage recommended at 4°C in a sealed container, protected from moisture and light.
- In-solution stability: store at -80°C for up to 6 months or -20°C for up to 1 month when sealed.
Medchemexpress LLC SB 202190 hydrochloride | 350228-36-3 | MFCD17215958 | 99.7% | 367.80 g·mol⁻1 | C20H15ClFN3O | 50 MG
SB 202190 hydrochloride is the hydrochloride salt of a selective p38 mitogen-activated protein kinase (MAPK) inhibitor used in biochemical and cellular research to probe p38 signaling pathways. It is supplied as a solid and as a ready-to-use DMSO solution, and is characterized by high purity and defined storage recommendations.
- Selective inhibitor of p38 MAPK isoforms.
- High purity suitable for research applications.
- Available as solid and as a 10 mM solution in DMSO.
- Light yellow solid appearance for easy visual inspection.
- Requires low-temperature, sealed storage to preserve stability.
TARGETMOL CHEMICALS INC N1-Acetylspermidine hydrochlor
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. N1-Acetylspermidine hydrochloride, an acetyl derivative of spermidine, serves as a substrate for polyamine oxidase and selectively elevates its levels in human colorectal adenocarcinomas. Purity 99.76%
Medchemexpress LLC Bestatin hydrochloride | 65391-42-6 | 99.94% | 5 MG
Bestatin hydrochloride is a chemical compound known for its role as a competitive inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase. It is utilized in cancer research and is available with a high purity of 99.94%. This product is intended for research use only.
- Inhibitor of CD13 (Aminopeptidase N)/APN
- Inhibitor of leukotriene A4 hydrolase
- Used for cancer research
- Enhances ATRA-induced differentiation
- Inhibits ATRA-driven phosphorylation of p38 MAPK
- Solid, white to off-white appearance
- Store at 4°C under nitrogen
Medchemexpress LLC DRP1i27 dihydrochloride | C20H28Cl2N6O | 1 ML
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). It binds to the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. This compound targets Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.
- Directly binds to and inhibits the GTPase activity of human Drp1.
- Increases cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner.
- Has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay.
TARGETMOL CHEMICALS INC TIROFIBAN HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist. purity: 99%