Hydrochlorides
Medchemexpress LLC Nisoxetine | 53179-07-0 | 98.6% | 100 MG
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It functions as an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels. This product is intended for research use only.
- Potently and selectively inhibits the noradrenaline transporter (NET) with a Kd of 0.76 nM.
- Acts as both an antidepressant and a local anesthetic.
- Can block voltage-gated sodium channels.
- Available in multiple quantities.
- Comes with a data sheet, COA, SDS, and handling instructions.
- Detailed solubility information provided for in vitro use.
Medchemexpress LLC Angoline hydrochloride | 21080-31-9 | 5 MG
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
- Potent and selective IL6/STAT3 signaling pathway inhibitor
- IC50 of 11.56 μM
- Inhibits STAT3 phosphorylation
- Inhibits its target gene expression
- Inhibits cancer cell proliferation
- Purity: >98%
Medchemexpress LLC 2,4-dichloro-5-(((2-((dimethylamino)methyl)phenyl)methoxy)methyl)pyrimidine hydrochloride | 2289726-31-2 | 99.9% | 375.72 | 50 MG
DCPT1061 hydrochloride is a potent inhibitor of histone methyltransferases, specifically targeting PRMT1, PRMT6, and PRMT8 in vitro. It exhibits weak inhibitory effects on other epigenetic enzymes like PRMT3, PRMT4, and PRMT5. This compound has demonstrated antitumor effects, making it a promising agent for cancer research.
- Strong inhibitory effect on PRMT1, PRMT6, and PRMT8.
- Minimal inhibition of PRMT3, PRMT4, and PRMT5.
- Exhibits antitumor properties.
- Suitable for research applications.
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 5 MG
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. It is intended for research use only and not for patient administration.
- Potent and selective P2X7 receptor antagonist
- High purity of 99.99%
- Appearance as a solid, white to off-white
- For research use only
Medchemexpress LLC preQ1 dihydrochlorid 1mg | 86694-45-3 | 252.10 g·mol⁻1 | C7H11Cl2N5O | 1 MG
PreQ1 dihydrochloride is a guanine-derived nucleobase precursor used in research on tRNA modification and queuine biosynthesis. It binds preQ1 riboswitch aptamers with high affinity and is supplied as the dihydrochloride salt for in vitro biochemical and molecular biology studies.
- High purity, typically 98.88%.
- Molecular weight 252.10 g·mol⁻1; formula C7H11Cl2N5O.
- Soluble in DMSO (125 mg/mL) and water (≈14.29 mg/mL) with sonication and warming to 60°C.
- White to light brown solid appearance.
- Store sealed at 4°C, protect from moisture and light; in solution store at -80°C up to 6 months.
Medchemexpress LLC SKF-96365 hydrochlor 10mM 1mL
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG
DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG
Medchemexpress LLC Buformin hydrochloride | 1190-53-0 | 99.78% | 50 MG
Buformin hydrochloride | 1190-53-0 | 99.78% | 50 MG
Medchemexpress LLC Queuine dihydrochloride | 86496-18-6 | 350.20 | 5 MG
Queuine dihydrochloride | 86496-18-6 | 350.20 | 5 MG
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 1 ML
Verubulin hydrochloride is the hydrochloride salt of verubulin (MPC-6827), a microtubule/tubulin inhibitor used in preclinical research. It is supplied as a ready-to-use 10 mM solution in DMSO and is also available as solid quantities for custom preparation. Intended for research use only.
- Highly pure product (98.7% typical).
- Provided as 10 mM, 1 mL solution in DMSO for ready-to-use applications.
- Available as solid in multiple masses (mg scale) for flexible dosing.
- Molecular weight 315.8 g/mol; formula C17H18ClN3O.
- Suitable for in vitro and in vivo preclinical research; not for human use.
Medchemexpress LLC Epertinib hydrochloride | 2071195-74-7 | >98.0% | 596.48 g/mol | C30H28Cl2FN5O3 | 1 ML
Epertinib hydrochloride is the hydrochloride salt of epertinib, a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 used in oncology research. The product is supplied as a 10 mM solution in DMSO (1 mL) and as solid powders; consult the datasheet and safety information for handling and purity details.
- Potent, reversible inhibitor of EGFR, HER2, and HER4.
- Suitable for in vitro and in vivo oncology research.
- Available as a 10 mM DMSO solution for ready-to-use assays.
- Also available as solid for formulation or long-term storage.
- Molecular weight 596.48 g/mol and CAS number 2071195-74-7.
Medchemexpress LLC Bestatin hydrochloride (Ubenimex hydrochloride) | 65391-42-6 | MFCD00058004 | 99.9% | 100 MG
Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research. Bestatin hydrochloride is also known to have several biological activities, including:
- Inhibitor of CD13 (aminopeptidase N)/APN and leukotriene A4 hydrolase
- Enhances ATRA-induced differentiation in ATRA-sensitive APL NB4 cells
- Inhibits ATRA-driven phosphorylation of p38 MAPK
- Slows cell cycle progression in D. discoideum
- Inhibits mitosis and inherent multinuclearity in D. discoideum
- Reduces CD13 expression in diabetic mice
- Inhibits MMP-9 specific gelationolytic band densities in diabetic mice
- Inhibits VEGF and heparanase expression in diabetic mice
- Increases splenocytes producing hemolytic anti-SRBC antibodies (at 0.1 mg/kg)
Medchemexpress LLC H3B-6545 hydrochloride | 2052132-51-9 | 99.2% | 604.04 | 1 ML
H3B-6545 hydrochloride | 2052132-51-9 | 99.2% | 604.04 | 1 ML
Medchemexpress LLC Verubulin hydrochloride | 917369-31-4 | 98.7% | 50 MG
Verubulin hydrochloride is the hydrochloride salt of verubulin (MPC-6827), a quinazoline-derived microtubule polymerization inhibitor with reported antitumor activity. It is supplied as a solid research reagent for preclinical studies investigating microtubule dynamics and anticancer mechanisms.
- Hydrochloride salt suitable for enhanced solubility in polar solvents.
- Potent microtubule polymerization inhibitor used in anticancer research.
- Reported to be brain-penetrant, enabling neurobiology applications.
- High purity typical for analytical and preclinical work (98.7%).
- Stable as a solid at 4°C; follow recommended storage conditions for solutions.
Medchemexpress LLC Terbinafine hydrochloride | 78628-80-5 | 99.9% | 327.89 | 500 MG
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. It is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. It also demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent antifungal agent
- Orally active
- Inhibits squalene epoxidase from Candida
- Demonstrates antibacterial activity against certain Gram-positive and Gram-negative bacteria
- Functions as a click chemistry reagent with an Alkyne group
- Exhibits primary fungicidal action against most fungal pathogens
- Effective topically and orally in experimental dermatophytoses