Hydrochlorides
Apexbio Technology LLC RS 127445 199864-87-4 10mg
RS 127445 (CAS 199864-87-4) is a highly selective antagonist of the serotonin 5-HT2B receptor displaying nanomolar affinity (pKi 9 5 pIC50 10 4) and approximately 1000-fold selectivity over other receptor subtypes By inhibiting 5-HT2B-mediated signaling RS 127445 suppresses serotonin-induced increases in inositol phosphate and intracellular calcium in cellular models In vivo administration in rat models reduces stress- and TNBS-induced visceral hypersensitivity and attenuates colonic motility responses RS 127445 is widely used to elucidate 5-HT2B receptor functions in neurogastroenterology and mechanisms of gastrointestinal hypersensitivity
Medchemexpress LLC DAPI dihydrochloride (4',6-Diamidino-2-phenylindole) | 28718-90-3 | 99.9% | 50 MG
DAPI (4',6-Diamidino-2-phenylindole) dihydrochloride is a fluorescent dye that strongly binds to double-stranded DNA at AT base pairs, causing a significant increase in fluorescence intensity. This property makes it widely used in fluorescence microscopy for DNA quantification and cell staining, capable of penetrating intact cell membranes. It also functions as an ASIC3 inhibitor and is explored in chronic pain treatment research.
- Binds strongly and specifically to DNA.
- Increases fluorescence intensity upon DNA binding.
- Used in fluorescence microscopy for DNA quantification.
- Stains both live and fixed cells by penetrating cell membranes.
- Acts as an acid-sensing ion channel 3 (ASIC3) inhibitor.
- Applicable in chronic pain treatment research.
- For research use only.
Sigma Aldrich Fine Chemicals Biosciences o-Phenylenediamine dihydrochloride tablet, 10 mg substrate per tablet | 615-28-1 | MFCD00012966 | 100TAB
o-Phenylenediamine dihydrochloride tablet, 10 mg substrate per tablet | Mol Wt: 181.06 | 615-28-1 | MFCD00012966 | 100TAB
Sigma Aldrich Fine Chemicals Biosciences 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | 23007-85-4 | MFCD00012790 | 100MG
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | Mol Wt: 209.72 | 23007-85-4 | MFCD00012790 | 100MG
Sigma Aldrich Fine Chemicals Biosciences 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | 23007-85-4 | MFCD00012790 | 10MG
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride powder | Mol Wt: 209.72 | 23007-85-4 | MFCD00012790 | 10MG
Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
Chem-Impex International, Inc. O-Benzyl-hydroxylamine hydrochloride | 2687-43-6 | MFCD00012952 | 100G
O-Benzyl-hydroxylamine hydrochloride, 2687-43-6, MFCD00012952, 100G
Medchemexpress LLC Dasatinib hydrochloride | 854001-07-3 | 99.3% | 524.47 g/mol | C22H27Cl2N7O2S | 500 MG
Dasatinib hydrochloride is the hydrochloride salt of dasatinib, a potent ATP-competitive dual Src/Bcr-Abl kinase inhibitor used in cancer research and cell signaling studies. It is supplied as a high-purity research reagent intended for in vitro and in vivo kinase inhibition assays and related biochemical applications.
- Potent ATP-competitive inhibitor of Src and Bcr-Abl kinases.
- Suitable for in vitro and in vivo research applications.
- Hydrochloride salt for improved solubility and handling.
- High purity (99.31% by HPLC) for reliable experimental results.
- Molecular formula C22H27Cl2N7O2S; molecular weight 524.47 g/mol.
- Available in a 500 mg research package.
Chem-Impex International, Inc. 2-Iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 10G
2-Iminothiolane hydrochloride, 4781-83-3, MFCD00039013, 10G
Selleck Chemical LLC VU 0364439
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with EC50 of 19 8 nM
Medchemexpress LLC L-368,899 hydrochloride | 160312-62-9 | 100.0% | 591.23 | 50 MG
L-368,899 hydrochloride | 160312-62-9 | 100.0% | 591.23 | 50 MG
Medchemexpress LLC L-778123 hydrochloride | 253863-00-2 | 99.9% | 442.34 | 1 ML
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively. For research use only, not for sale to patients. In vitro, it does not show obvious cytotoxicity on HT-29 and A549 cell lines (IC50: >100 μM) but can generate synergistic effects with Doxorubicin, with decreased IC50s of 1.72 and 1.52 μM respectively. It inhibits myeloid leukemia cell proliferation with IC50 values of 0.2 μM-1.8 μM for cell lines, and 0.1 μM-161.8 μM in primary samples. It inhibits H-RAS prenylation in HL-60 cells, and inhibits phosphorylated MEK-1/2 level. It also inhibits lymphocyte activation and function in human PBMCs.
- Dual inhibitor of FPTase and GGPTase-I
- Shows synergistic effects with Doxorubicin
- Inhibits myeloid leukemia cell proliferation
- Inhibits H-RAS prenylation and phosphorylated MEK-1/2 level
- Inhibits lymphocyte activation and function
TARGETMOL CHEMICALS INC Anabasine 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. (±) Anabasine is a muscle relaxant that can be used for muscle relaxation during surgery.
eMolecules 246257-69-2 | DICYCLOPROPYLAMINE HYDROCHLORIDE | MFCD06796385 | 1g
Ambeed | Ethyl 7-amino-5-chloro-1H-indole-2-carboxylate | 100mg | 596569065 | A644870 | 59694-51-8 | MFCD20923225 | 238.670 | C11H11ClN2O2
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