Hydrochlorides
Medchemexpress LLC TAK-960 dihydrochloride | 99.2% | 634.52 | 5 MG
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. It also demonstrates inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. This compound inhibits the proliferation of multiple cancer cell lines and shows significant efficacy against various tumor xenografts.
- Orally available
- Selective inhibitor of polo-like kinase 1 (PLK1)
- Inhibits proliferation of multiple cancer cell lines
- Exhibits significant efficacy against various tumor xenografts
- Causes accumulation of G2-M cells
- Leads to G2/M cell cycle arrest
Medchemexpress LLC SKF-96365 hydrochlor 50mg
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | MFCD07368623 | 99.9% | 495.07 g/mol | C22H39ClN2O6S | 10 MG
Tirofiban hydrochloride monohydrate is the hydrochloride monohydrate salt of tirofiban, a selective and reversible platelet integrin (Gp IIb/IIIa) antagonist supplied for research and analytical applications. It inhibits fibrinogen binding to the Gp IIb/IIIa receptor and is provided as a high-purity solid suitable for in vitro studies.
- Selective, reversible Gp IIb/IIIa antagonist suitable for platelet research.
- Inhibits fibrinogen binding to the Gp IIb/IIIa receptor.
- High purity (≈99.9%) for reproducible experimental results.
- Available in small laboratory quantities for analytical and preparative use.
- Supplied as a stable hydrochloride monohydrate salt for consistent handling.
Medchemexpress LLC ENMD-1068 hydrochloride | 2703451-51-6 | 98.3% | 319.87 | C15H30ClN3O2 | 10MM 1ML
ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist used in biochemical and cellular research to probe PAR2 signaling and related pathways such as TGF-β1/Smad. The compound is supplied as the hydrochloride salt with high reported purity and is offered both as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid pack sizes for flexibility in experimental workflows.
- Selective PAR2 antagonist suitable for signaling and fibrosis research.
- Provided as the hydrochloride salt with white to off-white appearance.
- Available as a 10 mM DMSO solution (1 mL) for immediate use in assays.
- Offered in solid quantities for custom formulation and dosing.
- High reported purity (~98.3%) and defined molecular weight for reliable dosing.
- Solubility data and storage recommendations provided for in vitro and in vivo use.
Medchemexpress LLC Arc 239 dihydrochloride | 55974-42-0 | MFCD02262215; MFCD16875414 | 99.2% | 480.43 | C24H31Cl2N3O3 | 5 MG
ARC 239 dihydrochloride is a small-molecule research compound that acts as a selective α2B/α2C adrenoceptor antagonist. It is supplied as a white to off-white solid intended for in vitro pharmacology and receptor-binding studies; reported binding data indicate greater affinity at α2B compared with α2A and α2C subtypes.
- Selective antagonist of α2B and α2C adrenoceptors.
- Reported pKd/pKi values indicate higher affinity for α2B subtype.
- High purity suitable for research applications.
- White to off-white solid form for convenient handling.
- Stable under recommended refrigerated storage.
- Useful for subtype-selective adrenergic receptor studies.
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | 99.7% | 269.77 | C14H20ClNO2 | 10 MG
Piperoxan hydrochloride is a research chemical described as an α2 adrenoceptor antagonist and an early-generation antihistamine. Supplied as a solid for laboratory use, it is used as a reference compound in receptor pharmacology and biochemical studies.
- α2 adrenoceptor antagonist activity
- First-generation antihistamine properties
- High reported purity (about 99.7%) suitable for research
- Solid form supplied in small laboratory pack sizes
- Molecular formula C14H20ClNO2; molecular weight 269.77
Medchemexpress LLC Nisoxetine | 53179-07-0 | 98.6% | 100 MG
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It functions as an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels. This product is intended for research use only.
- Potently and selectively inhibits the noradrenaline transporter (NET) with a Kd of 0.76 nM.
- Acts as both an antidepressant and a local anesthetic.
- Can block voltage-gated sodium channels.
- Available in multiple quantities.
- Comes with a data sheet, COA, SDS, and handling instructions.
- Detailed solubility information provided for in vitro use.
Medchemexpress LLC Angoline hydrochloride | 21080-31-9 | 5 MG
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
- Potent and selective IL6/STAT3 signaling pathway inhibitor
- IC50 of 11.56 μM
- Inhibits STAT3 phosphorylation
- Inhibits its target gene expression
- Inhibits cancer cell proliferation
- Purity: >98%
eMolecules 28356-58-3 | 4-Pyridineacetic acid | Combi-Blocks | MFCD03701446 | 137.138 | C7H7NO2 | 98.000 | OC(=O)Cc1ccncc1 | 1g | 357561050
4-Pyridineacetic acid | Combi-Blocks | 28356-58-3 | MFCD03701446 | 137.138 | C7H7NO2 | 98.000 | OC(=O)Cc1ccncc1 | 1g | 357561050
Medchemexpress LLC N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid dihydrochloride | 35369-53-0 | MFCD04113603 | >95.0% | 461.34 | C20H26Cl2N2O6 | 1 ML
HBED dihydrochloride is an orally active, hexadentate phenolic aminocarboxylate iron chelator (N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid dihydrochloride) supplied for research use in solution and solid formats for studies of iron binding and chelation biology.
- Orally active hexadentate iron chelator.
- Suitable for iron chelation research and biochemical assays.
- Supplied as ready-to-use 10 mM in DMSO solution and as solid material.
- Solid sizes available: 100 mg, 250 mg, 500 mg, 1 g.
- Molecular weight 461.34; formula C20H26Cl2N2O6.
- Typical purity specification ≥95.0% (batch dependent).
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 5 MG
Benzamil hydrochloride, an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor with an IC50 of approximately 100 nM. It also functions as a non-selective blocker of Deg/epithelial sodium channels (ENaC) and can enhance myogenic vasoconstriction. It inhibits TRPP3-mediated Ca2+-activated currents with an IC50 of 1.1 μM.
- Inhibits neuronal and heterologously expressed small conductance Ca2+-activated K-channels.
- Treatment with the compound (0.7 mg/kg/day; s.c.) resulted in an average survival until 16.1 weeks of age in stroke-prone spontaneously hypertensive rats (SHRSP).
Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | 98.5% | 406.31 | 50 MG
TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- Dual inhibitor of DNA topoisomerase I/II.
- Active on CCRF-CEM cells with an IC50 value of 5 nM.
- Significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells.
- Highly cytotoxic to Lewis lung carcinoma (LLC) cells.
- Inhibits the viability of HeLa cells with an IC50 of 40 nM.
- Disrupts signal recognition particle (SRP) complex formation and induces destabilization of SRP14 and SRP19.
- Causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells without obvious body weight loss.
- Liposomal TAS-103 is more active than free TAS-103 in vivo.
Medchemexpress LLC (±)-Bepridil hydrochloride hydrate | 74764-40-2 | 99.9% | 421.02 | 25 MG
Bepridil hydrochloride hydrate is a non-selective, long-acting calcium channel antagonist and sodium, potassium channel inhibitor. It exhibits antianginal and type I antiarrhythmic effects, and also functions as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. This product is intended for research on cardiovascular disorders.
- Non-selective calcium channel antagonist
- Long-acting
- Sodium channel inhibitor
- Potassium channel inhibitor
- Antianginal effects
- Type I antiarrhythmic effects
- Cardiac Na+/Ca2+ exchange (NCX1) inhibitor
- Blockades of Ca2+-dependent action potentials in vascular smooth muscle
- Blocks Ca currents and Na currents
- Decreases IKs under blockade of IKr
- Exhibits a half-life of averages 33±15 hours after single-dose administration
Medchemexpress LLC SKF-96365 hydrochlor 10mM 1mL
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Medchemexpress LLC DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG
DAPI dihydrochloride | 28718-90-3 | 99.9% | 500 UG