Vinyl halides
Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 500 MG
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor. It induces cell-cycle arrest and selective apoptosis in cancer cells, attenuating PI3K/Akt signaling.
- Orally bioavailable
- Highly selective and potent CK2 inhibitor
- Induces cell-cycle arrest in cancer cells
- Selectively induces apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Demonstrates robust antitumor activity in murine xenograft models
- Well-tolerated in vivo
Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.92% | C19H11ClN3NaO2 | 1 G
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. It induces cell-cycle arrest and selectively induces apoptosis in cancer cells, attenuates PI3K/Akt signaling, and its antiproliferative activity correlates with CK2α catalytic subunit expression. It also prevents leukemic cells from engaging a functional UPR and decreases pro-survival ER chaperon BIP/Grp78 expression.
- Highly selective and potent CK2 inhibitor (IC50 of 1 nM against CK2α and CK2α')
- Induces cell-cycle arrest and selective apoptosis in cancer cells
- Attenuates PI3K/Akt signaling and suppresses CK2-mediated PI3K/Akt/mTOR signaling
- Exerts anti-proliferative effects in hematological tumors
- Prevents leukemic cells from engaging a functional UPR and decreases pro-survival ER chaperon BIP/Grp78 expression
Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 5 MG
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor (IC50 values of 1 nM against CK2α and CK2α'). It induces cell-cycle arrest and selectively causes apoptosis in cancer cells, attenuates PI3K/Akt signaling, and demonstrates antiproliferative activity correlating with CK2α catalytic subunit expression. It also prevents leukemic cells from engaging a functional UPR to buffer proteotoxic stress and decreases pro-survival ER chaperon BIP/Grp78 expression.
- Causes cell-cycle arrest
- Induces apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Exhibits antiproliferative activity
- Prevents leukemic cells from engaging a functional UPR
- Decreases pro-survival ER chaperon BIP/Grp78 expression
- Induces cytotoxicity
- Suppresses CK2-mediated PI3K/Akt/mTOR signaling pathways
- Demonstrates robust antitumor activity in murine xenograft models
Medchemexpress LLC Silmitasertib sodium salt (CX-4945 sodium salt) | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 50 MG
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor, demonstrating IC50 values of 1 nM against CK2α and CK2α'. This compound induces cell-cycle arrest and selectively promotes apoptosis in cancer cells. It also attenuates PI3K/Akt signaling, decreases pro-survival ER chaperon BIP/Grp78 expression, and suppresses activation of CK2-mediated PI3K/Akt/mTOR signaling pathways in hematological tumors.
- Orally bioavailable and potent CK2 inhibitor
- Highly selective against CK2α and CK2α' (IC50 1 nM)
- Induces cell-cycle arrest and apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Suppresses CK2-mediated PI3K/Akt/mTOR signaling
Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 100 MG
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor.
- Causes cell-cycle arrest and selectively induces apoptosis in cancer cells by attenuating PI3K/Akt signaling.
- Antiproliferative activity correlates with CK2α catalytic subunit expression.
- Prevents leukemic cells from engaging UPR during PS-341 treatment, reducing BIP/Grp78 expression.
- Induces cytotoxicity and apoptosis, exerting anti-proliferative effects in hematological tumors.
- Demonstrates robust antitumor activity and reduces phospho-p21 (T145) in murine xenograft models.
Medchemexpress LLC CpG ODN 10101 (sodium) | 1234402-77-7 | 99.2% | 7,185.00 Da | 10 MG
CpG ODN 10101 (sodium) is a synthetic oligodeoxynucleotide that functions as a toll-like receptor 9 (TLR9) agonist. Supplied as the sodium salt for research use, it is employed to stimulate innate immune responses and study immunomodulatory effects, including cytokine production and B-cell activation.
- TLR9 agonist that stimulates dendritic cells and B cells.
- Induces interferon and proinflammatory cytokine production.
- Provided as a sodium salt to aid stability and handling.
- High purity suitable for research applications.
- Available in milligram-scale quantities for laboratory studies.
Medchemexpress LLC Alizarin Red S sodium | 130-22-3 | 25 MG
Alizarin Red S sodium is an anthraquinone-derived dye that binds calcium ions and is used to stain mineralized deposits in biological samples. It is commonly used in histology and cell biology to assess osteoblast differentiation and bone formation.
- Stains calcium deposits for histology and cell-based assays.
- Forms complexes with calcium for visualization of mineralized matrix.
- Water-soluble sodium salt suitable for aqueous staining procedures.
- Supplied in small laboratory quantities for research use.
Medchemexpress LLC Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-, sodium salt | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 1 ML
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor with IC50 values of 1 nM against CK2α and CK2α'. It exhibits potent anti-cancer activity.
- Orally bioavailable and potent CK2 inhibitor
- Highly selective for CK2α and CK2α'
- Causes cell-cycle arrest and induces apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Demonstrates robust antitumor activity in murine xenograft models
- Suitable for research use only
Medchemexpress LLC Adenosine, 8-bromo-, cyclic 3',5'-[hydrogen P(S)]-phosphorothioate], sodium salt (1:1) | 1573115-90-8 | 99.9% | 446.15 | 500 UG
Sp-8-Br-cAMPS sodium is a cAMP analog that activates protein kinase A (PKA). It is known to inhibit T-cell proliferation and the haemocyte non-self response in Lepidoptera larvae. This compound also inhibits phagocytosis of certain bacteria and modulates cytokine expression.
- Activates protein kinase A (PKA) with an EC50 of 360 nM
- Inhibits T-cell proliferation
- Inhibits haemocyte non-self response in Lepidoptera larvae
- Inhibits phagocytosis of *X. nematophila* and *B. subtilis*
- Modulates cytokine expression (IFN-γ, TNF-α, IL-2, IL-4)
Medchemexpress LLC Rp-8-Br-cAMPS sodium | 925456-59-3 | 446.15 | 500 UG
Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. It occupies cAMP binding sites on PKA type I regulatory subunits, which prevents PKA dissociation and activation. It can be used in the study of tumors and retrovirus-induced immune deficiency, and it also inhibits insulin secretion.
- Blocks the ability of 2-chloroadenosine to inhibit LAK cytotoxicity.
- Significantly reduces the inhibitory effect of 2-chloroadenosine on cytokine production.
- Inhibits insulin secretion in 832/13 cells.
- Improves immune function in a mouse retrovirus infection model.
- Strongly increases responses to the anti-CD3 mAb.
- Improved T cell responses.
Medchemexpress LLC TX1-85-1 | 1603845-32-4 | 99.7% | 580.68 | 1 MG
TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. It acts as the first selective Her3 ligand, forming a covalent bond with Cys721 in the ATP-binding site of Her3. This compound induces partial degradation of Her3 protein and attenuates Her3-dependent signaling, showing anti-proliferation effects in various cell lines.
- Irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM
- First selective Her3 ligand forming a covalent bond with Cys721
- Induces partial degradation of Her3 protein
- Attenuates Her3-dependent signaling
- Demonstrates anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively
Medchemexpress LLC Rp-8-Br-cAMPS sodium | 925456-59-3 | 446.15 | 1 MG
Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. It occupies cAMP binding sites on PKA type I regulatory subunits, preventing PKA dissociation and activation. It can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion.
- Completely blocks the ability of 2-chloroadenosine to inhibit LAK cytotoxicity.
- Significantly reduces the inhibitory effect of 2-chloroadenosine on cytokine production.
- Inhibits insulin secretion in 832/13 cells.
- Improves immune function in a mouse retrovirus infection model.
Medchemexpress LLC Prexigebersen sodium | C177H206N63Na18O110P17 | 1 MG
Prexigebersen sodium is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2). It is for research use only.
- Purity: 98.95%
- Chemical structure: DNA, d(P-ethyl)(A-T-A-T-T-T-G-G-C-G-A-T-G-G-C-T-T-C), sodium salt
- Molecular weight: 5520.6 (free acid)
- Appearance: Solid
- Color: Off-white to light yellow
- Target: ERK
- Pathway: MAPK/ERK pathway; Stem cell/Wnt
- Solubility (in vitro): H2O: ≥ 100 mg/mL
- Storage: -20°C, sealed, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture)