Dimethyl Sulfoxide
Selleck Chemical LLC JNK-IN-8 - 10mM 1mL in DMSO99.16 purity
JNK-IN-8 - 10mM 1mL in DMSO99.16 purity
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss.1L
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Sigma Aldrich Fine Chemicals Biosciences Promethazine sulfoxide Bri
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss500ML
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Apexbio Technology LLC Caspofungin(Synonyms: Cancidas, Caspofungin acetate, MK-0991, L-743872), 10mM (in 1mL DMSO), CAS: 162808-62-0.
Caspofungin (CAS 162808-62-0) is a small-molecule inhibitor of -1 3-glucan synthase an enzyme essential for the biosynthesis of -(1 3)-D-glucan a fundamental cell wall component in pathogenic fungi such as Candida albicans Caspofungin selectively inhibits -1 3-glucan synthase activity with a reported IC50 of approximately 0 6 nmol/L in membrane preparations of C albicans Caspofungin demonstrates potent antifungal activity against various Candida isolates including azole-resistant strains (MIC90 0 5 g/mL) and shows prolonged post-antifungal effects lasting 6 8 hours It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics
Apexbio Technology LLC URB597(Synonyms: URB-597, KDS-4103, FAAH inhibitor URB597, Cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester), 10mM (in 1mL DMSO), CAS: 546141-08-6.
URB597 (CAS 546141-08-6) also known as KDS-4103 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH) an enzyme responsible for intracellular hydrolysis of the endocannabinoid anandamide In vitro assays indicate that URB597 inhibits FAAH activity with IC values of 3 nM in human liver microsomes and 52 nM in rat brain membranes Intraperitoneal administration in rats results in FAAH inhibition within brain tissue (ID 0 15 mg/kg) URB597 exhibits minimal interaction with cannabinoid receptors anandamide transporters or other related receptors ion channels enzymes and transporters This selectivity makes URB597 valuable for investigating endocannabinoid signaling pathways in biomedical research
Apexbio Technology LLC Darapladib(Synonyms: SB-480848, Darapladib, LP-PLA2 inhibitor, SB480848), 10mM (in 1mL DMSO), CAS: A3349.
Darapladib (CAS 356057-34-6) is a selective inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) an enzyme strongly implicated in the progression and instability of atherosclerotic plaques In vitro Darapladib shows high potency toward Lp-PLA2 (IC50 approximately 270 pM) with minimal inhibition of other secretory PLA2 isoforms (e g III V X) Preclinical studies in ApoE-deficient mouse models demonstrate that inhibition of Lp-PLA2 attenuates vascular inflammatory processes and markedly reduces atherosclerotic lesion formation Clinically Darapladib administration in statin-treated patients significantly decreases plasma Lp-PLA2 activity and inflammatory markers indicating potential applications in cardiovascular research related to atherosclerosis and associated inflammation
Apexbio Technology LLC AZD7762(Synonyms: AZD-7762, AZD 7762, 860352-01-8), 10mM (in 1mL DMSO), CAS: 860352-01-8.
AZD7762 (CAS No 860352-01-8) is an ATP-competitive inhibitor targeting the checkpoint kinases Chk1 and Chk2 regulatory enzymes activated upon DNA damage that control cell-cycle progression through phosphorylation of CDC25 phosphatases By competitively binding the ATP-binding pocket of Chk1 AZD7762 blocks Chk1-mediated phosphorylation of CDC25C exhibiting an IC50 of approximately 5 nM and Ki of 3 6 nM This inhibition prevents DNA damage-induced cell cycle arrest and interrupts DNA repair mechanisms promoting apoptosis in tumor cells Consequently AZD7762 acts as a chemosensitizing agent enhancing the cytotoxic effects of DNA-damaging therapies in oncology research
Apexbio Technology LLC MLN8237 (Alisertib) 1028486-01-2 10mM (in 1mL DMSO)
MLN8237 (Alisertib CAS 1028486-01-2) is an orally administered small molecule inhibitor targeting Aurora A kinase (AAK) an enzyme frequently overexpressed in various cancers and linked to tumor proliferation and progression Developed from its predecessor MLN8054 to reduce benzodiazepine-like side effects MLN8237 potently inhibits Aurora A kinase through reversible ATP-competitive binding (Ki 0 43 nmol/L) Given its demonstrated anti-tumor activity in preclinical in vitro and in vivo studies MLN8237 is currently under investigation for treating advanced malignancies
Apexbio Technology LLC Fenretinide 65646-68-6 10mM (in 1mL DMSO)
Fenretinide (4-HPR) is a synthetic retinoic acid analog which acts primarily through inhibition of focal adhesion kinase (FAK) and modulation of related signaling cascades Fenretinide induces apoptosis in various tumor cell lines such as prostate ovarian cervical endometrial breast small-cell lung carcinoma and malignant hematopoietic cells Mechanistically Fenretinide promotes apoptotic cell death through reactive oxygen species (ROS)-mediated DNA fragmentation and disrupts tumor cell migration and invasion via interference with the FAK/AKT/GSK3 signaling axis and destabilization of -catenin Fenretinide is frequently utilized as a chemopreventive agent in oncology research particularly for investigating mechanisms of growth inhibition and cell migration suppression
Apexbio Technology LLC Triapine 236392-56-6; 200933-27-3; 143621-35-6 10mM (in 1mL DMSO)
Triapine is a small molecule thiosemicarbazone derivative known to inhibit ribonucleotide reductase an enzyme essential for the conversion of ribonucleotides to deoxyribonucleotides thereby interfering with DNA synthesis and repair pathways Through this inhibition mechanism Triapine exhibits antitumor activity in a range of experimental cancer models including human ovarian carcinoma xenografts and murine leukemia models and inhibits proliferation across multiple tumor cell lines Due to its mechanistic specificity Triapine serves as a useful chemical tool for biomedical research into nucleic acid metabolism cancer cell replication and therapeutic resistance mechanisms
Apexbio Technology LLC Y-27632 dihydrochloride 129830-38-2 10mM (in 1mL DMSO)
Y-27632 dihydrochloride (CAS 129830-38-2) is a small-molecule inhibitor targeting ROCK kinases (Rho-associated protein kinases) specifically interacting with the catalytic domains of ROCK-1 and ROCK-2 It inhibits their kinase activity with an IC50 of approximately 140 nM By targeting ROCK signaling Y-27632 disrupts Rho-mediated formation of cellular stress fibers influences cell cycle progression from G1 to S phase and interferes with cytokinesis It is commonly utilized in studies investigating cell proliferation cytoskeletal organization and stem cell viability