Dimethyl Sulfoxide
Apexbio Technology LLC Zafirlukast 107753-78-6 10mM (in 1mL DMSO)
Zafirlukast (CAS 107753-78-6) is an antagonist targeting cysteinyl leukotriene receptors (CysLTR) which mediate inflammatory signaling pathways By competitively inhibiting leukotriene receptor binding it disrupts the leukotriene-driven inflammatory response Zafirlukast demonstrates antagonist potency against leukotriene receptors with an IC50 value of approximately 0 6 M and exhibits moderate inhibitory activity on CYP2C9 enzyme (IC50 of about 7 0 M) In biomedical research Zafirlukast serves as a pharmacological tool for studying leukotriene-mediated inflammation and receptor signaling processes
Apexbio Technology LLC GW788388 452342-67-5 10mM (in 1mL DMSO)
GW788388 (CAS 452342-67-5) is a selective inhibitor targeting activin receptor-like kinase 5 (ALK5) the type I receptor for transforming growth factor-beta (TGF- ) It inhibits the kinase activity of ALK5 suppressing TGF- -mediated signaling cascades GW788388 demonstrates potent inhibition of ALK5 autophosphorylation with an IC50 of 18 nM leading to decreased Smad2 phosphorylation It also inhibits TGF- -induced epithelial-mesenchymal transition (EMT) cellular proliferation fibrosis and angiogenesis in various cell models such as NMuMG MDA-MB-231 RCC and U2OS In animal studies GW788388 ameliorates renal fibrosis in diabetic db/db mouse models highlighting its utility in investigating TGF- -driven pathophysiological processes
Apexbio Technology LLC N6-methyladenosine (m6A) 1867-73-8 10mM (in 1mL DMSO)
N6-methyladenosine (m6A) is a purine derivative functioning primarily as an adenosine receptor agonist and modulates adenylate cyclase activity with reported ED50 approximately 17 25 M It is a common internal modification in eukaryotic messenger RNAs predominantly occurring within consensus motif RRACH (R G or A H A C or U) and affecting RNA stability processing and translation Experimental studies indicate m6A application in cellular models such as murine erythroleukemia (MEL) cells reduces -globin mRNA accumulation thereby suppressing erythroid differentiation initiation Due to its epigenetic regulatory role m6A serves as a tool for studying RNA methylation-dependent gene expression and cellular differentiation
Medchemexpress LLC Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Medchemexpress LLC S63845 Solution, 10 mM * 1 mL in DMSO
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.