Dimethyl Sulfoxide
Medchemexpress LLC Ocedurenone 10 mM 1 mL in DMSOSolid Solvent
Ocedurenone 10 mM*1 mL in DMSOSolid + Solvent
Thermo Scientific Production Chemicals and Services DOE AND INGALLS
NC3952589 DIMETHYL SULFOXIDE MULTI 190LT
Apexbio Technology LLC ICG 001 847591-62-2 10mM (in 1mL DMSO)
ICG 001 is a small molecule inhibitor of the canonical Wnt/ -catenin signaling pathway Mechanistically it competes with -catenin for interaction with CREB-binding protein (CBP) thereby selectively disrupting CBP/ -catenin-mediated transcriptional activity driven by the TCF/ -catenin complex (IC50 3 M) Experimental studies demonstrated its use in assessing CBP-dependent biological functions regulated by Wnt signaling Research applications include investigating CBP/ -catenin roles in cancer cell proliferation such as colorectal cancer cells (HCT-116 SW480) glioblastoma stem cell growth and fibrotic responses in pulmonary and dermal experimental models Additionally ICG 001 is under evaluation in clinical studies aiming at treatment of colorectal cancer and leukemia
Apexbio Technology LLC Mirabegron (YM178) 223673-61-8 10mM (in 1mL DMSO)
Mirabegron (YM178 CAS 223673-61-8) is a selective agonist targeting the -adrenergic receptor ( -AR) Activation of -AR influences physiological responses in tissues including adipose cells prostate gastrointestinal tract and primarily the urinary bladder In CHO cells expressing human -adrenergic receptor subtypes mirabegron demonstrated selective agonist properties at -AR (EC 22 4 nM) showing minimal activity at - and -AR subtypes Animal studies revealed mirabegron reduced rhythmic bladder contraction frequency without affecting amplitude Its selective -AR agonist profile makes mirabegron pertinent for research on bladder dysfunction particularly overactive bladder conditions
Apexbio Technology LLC LDC1267 1361030-48-9 10mM (in 1mL DMSO)
LDC1267 (CAS 1361030-48-9) is a selective inhibitor of the TAM receptor tyrosine kinases Mer Tyro3 and Axl demonstrating IC50 values of less than 5 nM 8 nM and 29 nM respectively By inhibiting TAM signaling LDC1267 abolishes Gas6-mediated suppression in NKG2D-activated natural killer (NK) cells thus enhancing NK-mediated cytotoxicity Preclinical studies show reduced metastasis of melanoma and 4T1 breast tumor cells upon LDC1267 administration in mouse models an effect reliant on NK cell function LDC1267 provides a research tool for investigating TAM-regulated immune modulation in cancer models
Apexbio Technology LLC Flutamide 13311-84-7 10mM (in 1mL DMSO)
Flutamide is a synthetic nonsteroidal antiandrogen agent commonly employed in biomedical research and clinical oncology Its pharmacological activity is mediated through competitive antagonism at the androgen receptor (AR) whereby its active metabolite interacts specifically with AR exhibiting a receptor binding affinity at a K sub i /sub value around 55 nM By interfering with androgen signaling pathways flutamide inhibits AR-mediated transcriptional activity resulting in reduced cellular proliferation particularly in androgen-dependent tissues In research contexts this compound is frequently utilized to investigate AR-mediated cell biology androgen-dependent tumor development and as a pharmacological tool in model systems studying prostate cancer biology and therapeutic resistance mechanisms
Apexbio Technology LLC Epinephrine HCl 55-31-2 10mM (in 1mL DMSO)
Epinephrine hydrochloride is an adrenergic receptor agonist functioning as both a hormone and neurotransmitter Structurally epinephrine hydrochloride is the hydrochloride salt form of epinephrine facilitating receptor binding and signal transduction mediated by adrenergic receptor subtypes ( and ) Upon receptor activation it initiates downstream signaling pathways through G-protein-coupled mechanisms influencing intracellular second messengers such as cAMP calcium influx and protein kinase activity In biomedical research epinephrine hydrochloride serves as a pharmacological tool for investigating adrenergic receptor-mediated physiological responses including cardiac function modulation bronchodilation metabolic processes and vasoconstriction Its controlled application aids in studying sympathetic nervous system mechanisms cellular signaling cascades cardiovascular pharmacology and stress response frameworks
Apexbio Technology LLC LY2584702 1082949-67-4 10mM (in 1mL DMSO)
LY2584702 (CAS 1082949-67-4) is an orally bioavailable ATP-competitive inhibitor selectively targeting p70 S6 kinase (p70S6K) a serine/threonine kinase downstream of the PI3K/Akt/mTOR signaling cascade By inhibiting p70S6K activity LY2584702 effectively suppresses phosphorylation of ribosomal protein S6 (S6) thereby modulating protein translation LY2584702 exhibits potent inhibition of p70S6K (IC50 4 nM) and effectively reduces phosphorylated S6 levels in HCT116 colorectal cancer cells (IC50 between 0 1-0 24 M) Notably LY2584702 demonstrated anticancer activity in preclinical xenograft models supporting its role in targeted cancer research and therapeutic development