Dimethyl Sulfoxide
Apexbio Technology LLC Ro 3306 872573-93-8 10mM (in 1mL DMSO)
Ro 3306 (CAS 872573-93-8) is an ATP-competitive inhibitor targeting cyclin-dependent kinase 1 (CDK1) It selectively inhibits CDK1/cyclin B1 and CDK1/cyclin A complexes (Ki values of 35 nM and 110 nM respectively) thereby interfering with mitotic entry In DU145 cells Ro 3306 at 1 M diminishes BRCA1 localization at DNA double-strand breaks and suppresses RAD51 foci formation sensitizing these cells to DNA-damaging agents such as AZ12253801 Hence Ro 3306 is useful in studying cell cycle regulation DNA repair mechanisms and sensitization of cancer cells to targeted therapies
Apexbio Technology LLC PF-8380 1144035-53-9 10mM (in 1mL DMSO)
PF-8380 (CAS 1144035-53-9) is a selective inhibitor of autotaxin (ATX) a secreted enzyme with lysophospholipase D activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) As increased local LPA production promotes tumor proliferation and invasion targeting ATX reduces LPA synthesis PF-8380 demonstrates potent ATX inhibition (IC50 2 8 nM) significantly lowering LPA in plasma and tissue in rodent models It reduces Akt activation enhances radiosensitivity and diminishes growth and invasion of glioblastoma cells indicating utility in oncology research focused on ATX-LPA signaling pathways
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Medchemexpress LLC Ly2090314 1Ml Dmso Reconstitut | HY-16294-1ML DMSO RECONST
Ly2090314 1Ml Dmso Reconstitut
Medchemexpress LLC HY-Y0320 100mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 100mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Selleck Chemical LLC GSK2256098 10mM 1mL in DMSOPurity 99.82
GSK2256098 10mM 1mL in DMSOPurity 99.82
Selleck Chemical LLC Avapritinib 10mM 1mL in DMSOPurity 99.99
Avapritinib 10mM 1mL in DMSOPurity 99.99
TARGETMOL CHEMICALS INC TRAMETINIB DMSO SOLVATE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 2 nM)purity: 99%
Sigma Aldrich Fine Chemicals Biosciences DIMETHYL SULFOXIDE 500ML
NC3885792 DIMETHYL SULFOXIDE 500ML
Selleck Chemical LLC OSS_128167, 10mM (1mL in DMSO)
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis