Dimethyl Sulfoxide
Apexbio Technology LLC 3-Deazaneplanocin A (DZNep) hydrochloride 120964-45-6 10mM (in 1mL DMSO)
3-Deazaneplanocin A (DZNep) hydrochloride is a selective inhibitor targeting histone methyltransferase EZH2 exhibiting inhibitory activity with an IC50 range of 0 08-0 24 M Additionally DZNep inhibits S-adenosylhomocysteine hydrolase (SAHH) at a Ki of 50 pM EZH2 acts as a catalytic subunit of polycomb repressive complex 2 (PRC2) participating in modulation of gene expression via histone methylation Research demonstrates that DZNep suppresses EZH2-dependent gene regulation pathways in cancer cells leading to altered expression of cell-cycle and apoptosis-associated genes DZNep is commonly utilized in epigenetic studies of various tumors and metabolic dysfunction models including AML liver fibrosis and lipid accumulation studies
Apexbio Technology LLC SAG(Synonyms: Smoothened Agonist, SAG dihydrochloride, Hh-Smo agonist, SAG hydrochloride), 10mM (in 1mL DMSO), CAS: 912545-86-9.
SAG (CAS 912545-86-9) is a synthetic small-molecule agonist targeting the Smoothened (SMO) receptor a GPCR-like protein central to the Hedgehog (Hh) signaling pathway It activates SMO with an EC50 of approximately 3 nM thus stimulating downstream Gli transcription factor activity involved in embryonic development and adult tissue homeostasis At concentrations above 1 M SAG exhibits inhibitory effects on pathway signaling It binds directly to SMO forming an interaction with a reported dissociation constant (K D) around 59 nM SAG is employed in biomedical research notably to mitigate glucocorticoid-induced cerebellar injury in primary mouse neuronal cell cultures
Apexbio Technology LLC RK-33 1070773-09-9 10mM (in 1mL DMSO)
RK-33 is a small molecule inhibitor targeting DDX3 an RNA helicase frequently overexpressed in various cancer types including lung cancer DDX3 overexpression correlates with poorer survival outcomes in lung cancer patients suggesting therapeutic relevance Mechanistically RK-33 inhibits DDX3 enzymatic activity thereby disrupting downstream signaling pathways particularly the -catenin-dependent Wnt signaling axis In vitro studies indicate RK-33 induces cell cycle arrest at G1 phase promotes apoptosis and enhances cellular radiosensitivity in DDX3-high expressing cell lines (e g A549 H1299 H23 and H460 IC50 4 4 8 4 M) In preclinical in vivo testing using a Twist1/KrasG12D mouse lung cancer model combined treatment of RK-33 with radiation resulted in reduced tumor growth compared with radiation alone RK-33 serves as a research tool to investigate DDX3 biology and potential therapeutic strategies for cancers with elevated DDX3 expression
Apexbio Technology LLC Danusertib (PHA-739358) 827318-97-8 10mM (in 1mL DMSO)
Danusertib (PHA-739358 CAS 827318-97-8) is a pyrrolopyrazole-based aminopyrazole derivative that functions as a pan-inhibitor of aurora kinases prominently targeting aurora B kinase (ABK) It also exhibits inhibitory activity against several other tyrosine kinases including the T315I mutant form RET TRK-A and fibroblast growth factor receptor-1 (FGFR-1) Due to its broad kinase inhibition profile danusertib has demonstrated significant antitumor activity in various xenograft spontaneous and genetically engineered animal models and is thus useful in oncology research involving leukemia and solid tumors
Apexbio Technology LLC Fluoxetine HCl(Synonyms: Prozac, Sarafem, Fluoxetine Hydrochloride, Lilly 110140, Fluoxeren, Fluctin), 10mM (in 1mL DMSO), CAS: 56296-78-7.
Fluoxetine HCl (CAS 56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks presynaptic serotonin (5-HT) transporters resulting in elevated extracellular serotonin levels It modulates serotonergic signaling through inhibition of serotonin-induced membrane currents in cloned 5HT2C receptors exhibiting an IC50 around 20 M and binds 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM) Fluoxetine treatment has been shown in vivo to stimulate neurogenesis and enhance neuronal maturation and synaptic plasticity within rat hippocampus and prefrontal cortex Widely employed in neuroscience research fluoxetine aids in studies of depression stress resilience and neuro-regulatory mechanisms involving serotonergic signaling
Apexbio Technology LLC PD 173074 219580-11-7 10mM (in 1mL DMSO)
PD 173074 (CAS 219580-11-7) is a selective inhibitor targeting fibroblast growth factor receptors (FGFR) exerting its effects by suppressing FGFR tyrosine kinase phosphorylation It has demonstrated dose-dependent inhibitory activity against small cell lung cancer (SCLC) cell lines including H-510 and H-69 by reducing their proliferation colony formation and FGF-2 induced chemotherapy resistance in vitro In murine xenograft models of SCLC PD 173074 reduced tumor progression and significantly prolonged animal survival achieving durable complete responses in some cases PD 173074 represents an important tool compound for investigating the oncogenic role of FGFR signaling in cancer research
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Medchemexpress LLC Puromycin 10 Mm 1 Ml In Dmso | HY-B1743-10 MM 1 ML IN
Puromycin 10 Mm 1 Ml In Dmso
Apexbio Technology LLC Erlotinib 183321-74-6 10mM (in 1mL DMSO)
Erlotinib (CAS 183321-74-6) is an orally bioavailable reversible inhibitor targeting the epidermal growth factor receptor (EGFR) tyrosine kinase It acts by competitively binding the intracellular ATP-binding domain of EGFR thereby preventing receptor autophosphorylation and subsequent signaling cascades involved in proliferation angiogenesis and cell survival In biochemical assays Erlotinib demonstrates potent inhibition of EGFR tyrosine kinase (IC50 2 nmol/L) and cellular autophosphorylation of EGFR (IC50 20 nmol/L) Due to its selective interference with EGFR-mediated signaling Erlotinib is extensively employed in oncology research particularly in studies on EGFR-expressing tumor models
Apexbio Technology LLC BLZ945 953769-46-5 10mM (in 1mL DMSO)
BLZ945 (CAS 953769-46-5) is a selective small-molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF-1R) a receptor tyrosine kinase critical for macrophage and osteoclast differentiation proliferation migration and survival in response to macrophage colony-stimulating factor (M-CSF) BLZ945 inhibits CSF-1R kinase activity with an IC50 of 1 2 nM and reduces proliferation of M-CSF-dependent cells in vitro (e g EC50 of 71 M in MNFS-60 cells) In murine tumor models CSF-1R inhibition by BLZ945 reduces tumor-associated macrophage turnover and delays progression of breast and cervical tumors highlighting its utility in cancer and immune research
Apexbio Technology LLC Rosiglitazone(Synonyms: Avandia, BRL-49653, Rosiglitazone Maleate, Rosiglitazone Base, BRL49653C, RGZ, Rosiglizole), 10mM (in 1mL DMSO), CAS: 122320-73-4.
Rosiglitazone (CAS 122320-73-4) is a synthetic thiazolidinedione (TZD) that functions as an agonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor highly expressed in adipose tissues Upon ligand binding PPAR forms heterodimers with retinoid X receptors promoting transcriptional activation of genes regulating adipogenesis glucose uptake lipid metabolism and insulin sensitivity Through modulating fatty acid storage in adipose tissue and secretion of adipokines rosiglitazone significantly enhances insulin sensitivity making it extensively utilized in metabolic and diabetes research particularly type II diabetes studies
Apexbio Technology LLC Foretinib (GSK1363089) 849217-64-7 10mM (in 1mL DMSO)
Foretinib (GSK1363089 CAS 849217-64-7) is a small molecule inhibitor targeting receptor tyrosine kinases involved in angiogenesis and tumor progression notably receptors for vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) Foretinib inhibits tyrosine kinase activity of Met Ron KDR Flt-1 Flt-4 KIT Flt-3 Tie-2 and PDGFR / exhibiting IC50 values ranging from 0 4 to 9 6 nmol/L In cell-based assays foretinib reduces MET phosphorylation in mouse B16F10 melanoma and human PC-3 prostate cells (IC50 21 23 nmol/L) inhibits HGF-induced cell migration invasion and suppresses proliferation in B16F10 A549 and HT29 tumor cell lines Foretinib is utilized in preclinical cancer research targeting angiogenesis invasion and metastasis pathways
Apexbio Technology LLC PD0325901 391210-10-9 10mM (in 1mL DMSO)
PD0325901 (CAS 391210-10-9) is a small-molecule inhibitor selectively targeting mitogen-activated protein kinase kinase (MEK) an integral kinase within the RAS/RAF/MEK/ERK signaling cascade This pathway commonly exhibits elevated activity in various human cancers and contributes to cell proliferation survival and differentiation Treatment with PD0325901 reduces phosphorylated ERK (P-ERK) levels in vitro indicative of MEK inhibition In mouse tumor models administration of PD0325901 has demonstrated suppression of tumor growth underscoring its value as a research tool for elucidating MEK-mediated signaling and evaluating therapeutic potential in oncology
Apexbio Technology LLC ML-323(Synonyms: ML323, ML 323, USP1 inhibitor ML323, ML-323 USP1-UAF1 inhibitor, USP1/UAF1 inhibitor ML323), 10mM (in 1mL DMSO), CAS: 1572414-83-5.
ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex with a reported IC50 of 76 nM USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2 In cellular assays ML-323 inhibits USP1 UAF1-mediated deubiquitination enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families providing a valuable research tool for DNA repair and cancer biology studies