Dimethyl Sulfoxide
Apexbio Technology LLC SP 600125 129-56-6 10mM (in 1mL DMSO)
SP 600125 (CAS 129-56-6) is a selective reversible ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK) with reported IC50 values of 40 nM for JNK1 and JNK2 and 90 nM for JNK3 Initially identified via GST-c-Jun substrate and recombinant human JNK2 screening assays SP 600125 demonstrates marked specificity being approximately 300-fold more selective toward JNK isoforms compared to ERK1 and p38-2 kinases In cellular assays SP 600125 effectively suppresses JNK-mediated phosphorylation of c-Jun and attenuates expression of IL-2 IFN- and TNF- It is widely utilized in inflammation and signal transduction research
Apexbio Technology LLC Tirapazamine(Synonyms: SR-4233, WIN 59075, Tirazone, TPZ, 3-Amino-1,2,4-benzotriazine 1,4-dioxide), 10mM (in 1mL DMSO), CAS: 27314-97-2.
Tirapazamine (CAS 27314-97-2) also known as SR259075 Win59075 or SR4233 is an investigational anticancer agent selectively activated under hypoxic conditions characteristic of solid tumors The compound is bioreduced in hypoxic tumor microenvironments to cytotoxic free radicals leading to cellular damage Tirapazamine downregulates hypoxia-inducible factor-1 (HIF-1 ) thereby influencing pathways associated with tumor adaptive mechanisms to hypoxia Combined treatment with tirapazamine and topoisomerase I inhibitors (such as SN-38 the active metabolite of irinotecan) enhances apoptosis via mitochondria-mediated caspase activation and weakened DNA repair signaling Preclinical investigations including hepatocellular carcinoma xenografts confirm this enhanced tumor suppression Clinical trials evaluating tirapazamine s anticancer efficacy are ongoing
Apexbio Technology LLC (+)-Bicuculline 485-49-4 10mM (in 1mL DMSO)
( )-Bicuculline is a competitive antagonist of gamma-aminobutyric acid type A (GABA A) receptors frequently employed as a pharmacological tool to elucidate the functional roles of inhibitory neurotransmission mediated by GABA A By antagonizing GABA binding this compound prevents chloride ion influx leading to reductions in neuronal inhibitory postsynaptic potentials (IPSPs) Additionally ( )-Bicuculline blocks small conductance calcium-activated potassium (SK) channels affecting neuronal excitability and firing patterns It is commonly utilized in electrophysiological studies such as patch-clamp or extracellular recordings to investigate synaptic transmission neuroplasticity mechanisms and epileptic activity models ( )-Bicuculline inhibits GABA A receptors with an IC 50 typically reported in the low micromolar range (approximately 2 5 M)
Medchemexpress LLC Deg-77 10Mm 1Ml /Dmso Solution | HY-157334-10MM 1ML SOLUTN
Deg-77 10Mm 1Ml /Dmso Solution
Apexbio Technology LLC CVT-313 199986-75-9 10mM (in 1mL DMSO)
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Apexbio Technology LLC Flunixin Meglumin 42461-84-7 10mM (in 1mL DMSO)
Flunixin meglumine (CAS 42461-84-7) is a potent non-steroidal anti-inflammatory drug (NSAID) known to inhibit cyclooxygenase (COX) enzymes It exerts its biological effects primarily by blocking prostaglandin synthesis through non-selective inhibition of COX isoforms exhibiting an IC50 of approximately 1 nM Preclinical studies indicate analgesic and antipyretic properties in rodent and primate pain models Flunixin meglumine is utilized experimentally to modulate inflammatory responses particularly in veterinary models involving ischemic enteritis endotoxemia and colic
Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders
Apexbio Technology LLC Apatinib 10mM (in 1mL DMSO)
B2303 is a synthetic small molecule designed for biomedical research acting primarily as an inhibitor targeting specific intracellular signaling pathways involved in cell proliferation and survival It modulates intracellular signaling cascades implicated in pathological conditions such as inflammation cancer progression and aberrant cell growth B2303 serves as a molecular probe suitable for investigating intracellular processes and as a tool for dissecting signal transduction mechanisms enabling researchers to explore therapeutic targets for various diseases
Apexbio Technology LLC Bay 11-7085(Synonyms: BAY-11-7085, BAY 117085, BAY117085, Bay11-7085, BAY 11 7085, BAY-117085, Bay 11 7085), 10mM (in 1mL DMSO), CAS: 196309-76-9.
Bay 11-7085 (CAS 196309-76-9) is a soluble inhibitor of nuclear factor-kappa B (NF- B) activation It inhibits cell proliferation and promotes apoptosis in various cell types through interference with NF- B signaling pathways Studies have demonstrated that Bay 11-7085 decreases DNA synthesis in endometriotic stromal cells (ECSCs) leading to cell cycle arrest at G0/G1 phase Furthermore treatment with Bay 11-7085 induces apoptosis by downregulating anti-apoptotic proteins such as Bcl-2 and Bcl-XL while enhancing activation of caspase-3 caspase-8 and caspase-9 Bay 11-7085 is commonly employed as a chemical probe in biomedical research on inflammation and apoptosis pathways
Apexbio Technology LLC Methazolamide 554-57-4 10mM (in 1mL DMSO)
Methazolamide (CAS 554-57-4) is a sulfonamide-derived inhibitor of carbonic anhydrase (CA) selectively targeting isoforms CAII and CAIV with IC50 values of 8 1 nM and 80 3 nM respectively By suppressing CA activity methazolamide reduces bicarbonate ion production thus decreasing fluid secretion and intraocular pressure consequently it has clinical use in glaucoma management Recent studies indicate this compound also exhibits insulin-sensitizing properties distinct from other CA inhibitors notably reducing hepatic glucose output suggesting potential applications in diabetes research and metabolic disorders
Apexbio Technology LLC Chlorothiazide 58-94-6 10mM (in 1mL DMSO)
Chlorothiazide is a sulfonamide-derived diuretic compound known for its inhibitory action on carbonic anhydrase enzymes It functions by reducing sodium and chloride ion reabsorption via blockade of renal tubular transport mechanisms which subsequently promotes increased urine output Structurally Chlorothiazide contains a benzothiadiazine ring system contributing to its specific interaction with renal transport channels and carbonic anhydrase enzymes In biomedical research Chlorothiazide serves as a pharmacological tool to investigate ion transport pathways renal physiologic processes and mechanisms underlying fluid balance regulation Additionally it is utilized in experimental models studying electrolyte homeostasis and disorders associated with abnormal sodium or chloride retention
Apexbio Technology LLC EHT 1864(Synonyms: EHT-1864, EHT1864, RAC inhibitor EHT1864, Rac GTPase inhibitor EHT 1864), 10mM (in 1mL DMSO), CAS: 754240-09-0.
EHT 1864 (CAS 754240-09-0) is a small-molecule inhibitor targeting Rac family GTPases with strongest affinity and inhibitory activity toward Rac1 It interacts directly with Rac isoforms Rac1 Rac1b Rac2 and Rac3 exhibiting Kd values of approximately 40 nM 50 nM 60 nM and 250 nM respectively By disrupting nucleotide binding EHT 1864 blocks Rac1 activation and prevents the formation of active Rac1/PAK-RBD complexes thus inhibiting downstream cellular functions such as PDGF-stimulated lamellipodia formation and Rac1-mediated cellular transformation This compound serves as a valuable tool in cell biology research for studying Rac-dependent signaling pathways and cellular dynamics
Apexbio Technology LLC KPT-330 1393477-72-9 10mM (in 1mL DMSO)
KPT-330 (CAS 1393477-72-9) is an orally bioavailable small-molecule inhibitor selectively targeting chromosome region maintenance 1 protein (CRM1) a nuclear export receptor involved in the active transport of tumor suppressors transcription factors and cell-cycle regulators Overexpression and deregulation of CRM1 are frequently associated with cancer progression KPT-330 inhibits CRM1 function promoting nuclear retention of regulatory proteins such as p21 and inducing apoptosis through activation of apoptotic signaling pathways (e g PAR-4 activation Bax upregulation PARP cleavage caspase-3 activation) In preclinical studies KPT-330 demonstrated antitumor activity against renal cell carcinoma non-small cell lung cancer and pancreatic cancer models
Apexbio Technology LLC GW0742 317318-84-6 10mM (in 1mL DMSO)
GW0742 is a synthetic selective agonist of peroxisome proliferator-activated receptor / (PPAR / ) a ligand-dependent transcription factor involved in regulating lipid metabolism inflammation and energy homeostasis Activation of PPAR / modulates downstream gene transcription influencing physiological processes including inflammatory responses and neuronal protection Experimental studies demonstrate GW0742 s role in attenuating inflammation-mediated tissue injury such as ischemia/reperfusion-induced intestinal damage as well as mitigating radiation-induced neuroinflammation and cognitive impairment in animal models Thus GW0742 serves as a research tool to study PPAR / specific pathways in inflammatory diseases metabolic processes and neuroprotective mechanisms