Dimethyl Sulfoxide
Apexbio Technology LLC Romidepsin (FK228, depsipeptide) 128517-07-7 10mM (in 1mL DMSO)
Romidepsin (FK228 depsipeptide CAS 128517-07-7) is a small-molecule inhibitor targeting histone deacetylases (HDACs) Initially isolated from Chromobacterium violaceum romidepsin preferentially inhibits class I enzymes HDAC1 and HDAC2 over class II HDAC4 and HDAC6 Inhibition of HDAC activity by romidepsin results in increased histone acetylation promoting transcriptional activation of tumor suppressor genes Mechanistically this compound can trigger cellular differentiation cell-cycle arrest apoptosis and altered gene expression in various malignancies Romidepsin serves as a research tool to investigate epigenetic regulation and has notable anticancer properties in cell models such as neuroblastoma and cutaneous T-cell lymphoma
Apexbio Technology LLC LY2886721 1262036-50-9 10mM (in 1mL DMSO)
LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development
Apexbio Technology LLC JSH-23 749886-87-1 10mM (in 1mL DMSO)
JSH-23 (CAS 749886-87-1) is a small-molecule inhibitor of NF- B transcriptional activity exhibiting an IC50 of approximately 7 1 M Mechanistically JSH-23 prevents NF- B-mediated gene transcription by reducing nuclear localization and DNA binding activity of the NF- B p65 subunit without interfering with I B degradation In LPS-stimulated RAW 264 7 macrophages JSH-23 decreases expression of pro-inflammatory mediators including IL-6 IL-1 COX-2 and TNF- and inhibits apoptotic chromatin condensation This compound serves as a research tool for studying NF- B signaling and related inflammatory processes
Apexbio Technology LLC OTX-015 202590-98-5 10mM (in 1mL DMSO)
OTX-015 (CAS 202590-98-5) is a selective inhibitor of BRD2 BRD3 and BRD4 proteins within the BET (bromodomain and extra-terminal) family involved in transcriptional regulation By disrupting the interaction between these BRD proteins and acetylated histone H4 OTX-015 exhibits inhibitory activity demonstrated by IC50 values between 92 and 112 nM and in vitro EC50 ranging from 10 to 19 nM OTX-015 treatment reduces proliferation (GI50 60 200 nM) induces G1 arrest and promotes apoptosis in various human cancer cell models In xenograft mouse studies of BRD-NUT midline carcinoma orally administered OTX-015 significantly suppresses tumor growth showing potential utility for cancer research
Apexbio Technology LLC BIX 02189 1094614-85-3 10mM (in 1mL DMSO)
BIX 02189 is a selective kinase inhibitor targeting MEK5 a mitogen-activated protein kinase kinase It belongs to the chemical class of dihydroindolone-based kinase inhibitors Mechanistically BIX 02189 binds and inhibits the catalytic activity of MEK5 leading subsequently to suppression of ERK5 phosphorylation without affecting closely related kinases such as MEK1 MEK2 ERK2 or JNK2 In cellular studies using cultured HeLa and HEK293 cells BIX 02189 inhibits transcriptional activity mediated by downstream substrate MEF2C as well as ERK5 phosphorylation Additionally BIX 02189 has demonstrated inhibition of lymphatic endothelial cell sprouting in three-dimensional lymphangiogenesis assays indicating its applicability in angiogenesis and signal transduction research
Apexbio Technology LLC Levosimendan 141505-33-1 10mM (in 1mL DMSO)
Levosimendan (CAS 141505-33-1) is a small molecule calcium sensitizer that exerts its pharmacological action by binding selectively and in a calcium-dependent manner to cardiac troponin C (cTnC) Through this interaction levosimendan facilitates cardiac muscle contraction without significantly increasing intracellular calcium concentrations Research indicates utility in heart failure treatment where improved myocardial contractility is therapeutically desirable Currently levosimendan is evaluated extensively in Phase 4 clinical studies to explore its efficacy and therapeutic profile
Sigma Aldrich Fine Chemicals Biosciences Methyl phenyl sulfoxide >=97% | 1193-82-4 | MFCD00002088 | 25G
Methyl phenyl sulfoxide >=97% | Purity: >=97% | Mol Wt: 140.2 | 1193-82-4 | MFCD00002088 | 25G
Apexbio Technology LLC Entecavir Hydrate 209216-23-9 10mM (in 1mL DMSO)
Entecavir hydrate is an antiviral compound that acts as a reverse transcriptase (RT) inhibitor specifically targeting hepatitis B virus (HBV) infection It inhibits HBV DNA replication by interacting with the viral reverse transcriptase enzyme thus preventing the synthesis of complementary DNA from the viral RNA template Entecavir hydrate is frequently employed in antiviral studies and clinical research related to hepatitis B treatment regimens In studies involving chronic HBV-infected patients entecavir hydrate combined with peginterferon alpha-2b therapy has shown significant suppression of viral DNA levels and reduced covalently closed circular DNA (cccDNA) within hepatocytes The reported IC50 value of entecavir hydrate against HBV DNA polymerase activity typically ranges below 10 nM in cellular assay systems enabling its utility in both preclinical and clinical antiviral investigations
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 1L
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 1L
Apexbio Technology LLC MC1568 852475-26-4 10mM (in 1mL DMSO)
MC1568 (CAS 852475-26-4) is a histone deacetylase (HDAC) inhibitor derived from the (aryloxopropenyl)pyrrolyl hydroxyamide chemical class It selectively targets class II HDAC enzymes particularly class IIa subtypes (HDAC4 HDAC5 HDAC7 HDAC9) inhibiting maize class II HDAC activity with an IC50 of 22 M MC1568 modulates muscle differentiation pathways by reducing MEF2D expression stabilizing HDAC-HDAC3-MEF2D complexes and preventing MEF2D acetylation in cultured myocytes It also interferes with differentiation signals mediated via RAR and PPAR nuclear receptors serving as a valuable tool in epigenetic and cellular differentiation studies
Apexbio Technology LLC Flunixin Meglumin 42461-84-7 10mM (in 1mL DMSO)
Flunixin meglumine (CAS 42461-84-7) is a potent non-steroidal anti-inflammatory drug (NSAID) known to inhibit cyclooxygenase (COX) enzymes It exerts its biological effects primarily by blocking prostaglandin synthesis through non-selective inhibition of COX isoforms exhibiting an IC50 of approximately 1 nM Preclinical studies indicate analgesic and antipyretic properties in rodent and primate pain models Flunixin meglumine is utilized experimentally to modulate inflammatory responses particularly in veterinary models involving ischemic enteritis endotoxemia and colic
Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 10mM (in 1mL DMSO)
17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
Apexbio Technology LLC Zalcitabine 7481-89-2 10mM (in 1mL DMSO)
Zalcitabine is a nucleoside analog inhibitor targeting viral reverse transcriptase a key enzyme promoting viral replication By competitively binding to the active site of reverse transcriptase zalcitabine terminates DNA chain elongation effectively inhibiting viral DNA synthesis In vitro studies have demonstrated inhibitory activity against HIV-1 with reported IC50 values ranging approximately from 0 03 to 0 3 M Zalcitabine is frequently utilized in biomedical research as an antiviral reference molecule for studying HIV therapeutic targets antiviral drug resistance and mechanisms of reverse transcription inhibition
Medchemexpress LLC Dnl343 Solution 10Mm 1Ml Dmso | HY149555-10MM 1ML DMSO
Dnl343 Solution 10Mm 1Ml Dmso