Dimethyl Sulfoxide
Medchemexpress LLC Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Apexbio Technology LLC BMX-IN-1(Synonyms: BMX Kinase Inhibitor, ETK kinase inhibitor, BMX-IN1, BMX inhibitor, ETK inhibitor), 10mM (in 1mL DMSO), CAS: 1431525-23-3.
BMX-IN-1 (CAS 1431525-23-3) is a highly selective irreversible inhibitor targeting BMX (bone marrow kinase on chromosome X also known as ETK) a member of the Tec tyrosine kinase family BMX is prominently expressed in arterial endothelium and myeloid hematopoietic cells functioning in ischemia-induced arterial and lymphatic vessel formation processes and contributing to tumor growth In cellular models expressing Tel-BMX fusion proteins BMX-IN-1 treatment at low doses effectively reduces proliferation highlighting its potential utility in cancer research particularly prostate cancer studies
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 10mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC PF-543 1415562-82-1 10mM (in 1mL DMSO)
PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking
Apexbio Technology LLC Riluzole 1744-22-5 10mM (in 1mL DMSO)
Riluzole (CAS 1744-22-5) is a small molecule modulator of glutamatergic neurotransmission exhibiting multiple mechanisms of neuroprotection Its action primarily involves inhibition of voltage-gated sodium channels modulation of high-voltage-activated calcium and potassium channels and interference with protein kinase C activity collectively mitigating neuronal excitotoxicity In cultured rat cortical neurons riluzole inhibits inward sodium currents with an IC50 of 51 M At submicromolar to micromolar concentrations riluzole enhances sodium-dependent glutamate uptake mediated by the GLAST GLT1 and EAAC1 transporters Owing to these properties riluzole is commonly utilized in neuroscience research on excitotoxicity neurodegeneration and related pathologies
Apexbio Technology LLC GDC-0879(Synonyms: AR-00341677, GDC0879, GDC 0879, G-0879, G0879), 10mM (in 1mL DMSO), CAS: 905281-76-7.
GDC-0879 (CAS 905281-76-7) is a selective inhibitor of B-Raf kinase targeting the Raf/MEK/ERK signaling cascade implicated in tumorigenesis It specifically inhibits B-Raf harboring the V600E mutation demonstrating IC50 values of 0 13 nM against purified mutant B-Raf and 63 nM for phosphorylated ERK in MALME-3M cells In vitro assays using V600E mutant cell lines (A375 melanoma Colo205 colorectal cancer) illustrate the compound s selectivity towards B-Raf and related C-Raf kinases In mouse xenografts expressing human BRAFV600E tumors GDC-0879 treatment results in sustained ( 90%) inhibition of ERK phosphorylation and reduced tumor progression highlighting its research value in oncology studies involving Raf pathway modulation
Apexbio Technology LLC CH5138303 959763-06-5 10mM (in 1mL DMSO)
CH5138303 (CAS 959763-06-5) is a potent inhibitor targeting Heat Shock Protein 90 (HSP90) exhibiting strong binding affinity with a Kd of 0 48 nM HSP90 a molecular chaperone regulates protein folding stability and degradation and maintains oncogenic proteins crucial to tumor cell proliferation CH5138303 effectively reduces protein levels and phosphorylation of HSP90 client proteins including Raf1 AKT EGFR and HER2 in NCI-N87 cancer cells In animal studies using human gastric cancer NCI-N87 xenografts oral administration of CH5138303 demonstrates significant antitumor activity achieving a tumor growth inhibition (TGI) rate of 136% at an ED of 3 9 mg/kg
Apexbio Technology LLC Ronidazole 7681-76-7 10mM (in 1mL DMSO)
Ronidazole is a nitroimidazole compound exhibiting both antiprotozoal and antibacterial activities Its mechanism of action involves the generation of metabolites that interact with microbial DNA resulting in DNA damage and inhibition of nucleic acid synthesis Ronidazole is commonly employed in veterinary research settings to investigate therapeutic interventions against protozoan parasites such as Tritrichomonas foetus infections in feline models Histomonas meleagridis-mediated histomoniasis and Brachyspira hyodysenteriae-related swine dysentery It can be administered orally to experimental animal subjects for clarifying pathological mechanisms and therapeutic pathways in parasitic disease models Currently detailed IC50 data for Ronidazole remain underreported in literature
Apexbio Technology LLC Entinostat (MS-275,SNDX-275) 209783-80-2 10mM (in 1mL DMSO)
Entinostat (MS-275 SNDX-275 CAS 209783-80-2) is an orally bioavailable small molecule inhibitor targeting histone deacetylases (HDACs) a family of enzymes involved in transcriptional regulation by modifying histone acetylation Specifically entinostat exhibits inhibitory activity against class I HDAC enzymes HDAC1 HDAC3 and HDAC8 with reported IC50 values of 0 368 M 0 501 M and 63 4 M respectively In preclinical investigations entinostat demonstrates anti-proliferative effects in diverse human tumor cell lines including breast colon lung multiple myeloma ovarian pancreatic prostate cancers and leukemia Due to these properties entinostat is widely utilized in oncology research
Apexbio Technology LLC PF-8380 1144035-53-9 10mM (in 1mL DMSO)
PF-8380 (CAS 1144035-53-9) is a selective inhibitor of autotaxin (ATX) a secreted enzyme with lysophospholipase D activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) As increased local LPA production promotes tumor proliferation and invasion targeting ATX reduces LPA synthesis PF-8380 demonstrates potent ATX inhibition (IC50 2 8 nM) significantly lowering LPA in plasma and tissue in rodent models It reduces Akt activation enhances radiosensitivity and diminishes growth and invasion of glioblastoma cells indicating utility in oncology research focused on ATX-LPA signaling pathways
Medchemexpress LLC Dbet6 10Mm 1Md Dmso Reconstit | HY-112588-10MM-DMSO-RECON
Dbet6 10Mm 1Md Dmso Reconstit