Dimethyl Sulfoxide
Apexbio Technology LLC GW3965 HCl 405911-17-3 10mM (in 1mL DMSO)
GW3965 HCl is a selective non-steroidal agonist targeting liver X receptors (LXR and LXR ) nuclear transcription factors involved in cholesterol and lipid metabolism Activation of LXRs modulates cholesterol homeostasis by enhancing cholesterol efflux from macrophages stimulating hepatic bile acid synthesis and reducing intestinal cholesterol absorption GW3965 recruits steroid receptor coactivator-1 (SRC-1) to human LXRR in vitro and functions as a full agonist on cellular assays for both LXR and LXR receptors In animal studies oral administration elevated plasma HDL cholesterol levels and increased expression of the cholesterol transporter ABCA1 in macrophages GW3965 is useful in research investigating cholesterol metabolism atherosclerosis and vascular responses mediated by Angiotensin II signaling
Apexbio Technology LLC Vemurafenib (PLX4032, RG7204) 918504-65-1 10mM (in 1mL DMSO)
Vemurafenib (PLX4032 RG7204 CAS 918504-65-1) is a small-molecule inhibitor targeting BRAF kinase primarily inhibiting the activity of the oncogenic BRAF V600E mutant by competitively binding its ATP-binding site It also inhibits related kinases such as CRAF ARAF and wild-type BRAF In cells lacking BRAF mutations vemurafenib may paradoxically stimulate downstream MEK signalling due to transactivation mechanisms within RAF dimers Vemurafenib serves as an important research tool for investigating RAF-mediated signaling pathways in oncology particularly in melanoma studies
Apexbio Technology LLC SLx-2119 911417-87-3 10mM (in 1mL DMSO)
SLx-2119 (CAS 911417-87-3) also known as KD-025 is a selective inhibitor targeting Rho-associated protein kinase 2 (ROCK2) exhibiting an IC50 of approximately 105 nM ROCK2 is a serine/threonine kinase central to cytoskeletal modulation and cellular signaling particularly expressed within neuronal and vascular cells SLx-2119 reduces connective tissue growth factor (CTGF) mRNA expression selectively in human intestinal smooth muscle cells isolated from radiation-induced fibrosis tissue (RE-SMC) whereas normal smooth muscle cells remain unaffected Additionally in a murine model of focal cerebral ischemia SLx-2119 treatment yields a dose-dependent decrease in infarct size across aged and diabetic models highlighting its research applicability in ischemic stroke and fibrotic disorders
Apexbio Technology LLC Melatonin(Synonyms: N-acetyl-5-methoxytryptamine, MEL, Circadin, Melovine, Melatol), 10mM (in 1mL DMSO), CAS: 73-31-4.
Melatonin (CAS 73-31-4) is a naturally occurring hormone functioning primarily as an agonist at the G protein-coupled melatonin receptors MT and MT Through receptor activation melatonin regulates circadian rhythmicity and contributes significantly to sleep-wake cycle maintenance Additionally melatonin demonstrates immunomodulatory capabilities and possesses robust antioxidant properties in vivo combating oxidative stress Due to these characteristics it is frequently investigated in research related to sleep disorders circadian biology immune function and oxidative stress signaling pathways
Apexbio Technology LLC HTH-01-015(Synonyms: HTH01015, WZ4003, NUAK1 inhibitor WZ4003, NUAK1-IN-1, NUAK1 inhibitor, WZ-4003), 10mM (in 1mL DMSO), CAS: 1613724-42-7.
HTH-01-015 (CAS 1613724-42-7) is a highly selective inhibitor targeting the NUAK1 kinase exhibiting potent inhibitory activity with an IC50 of approximately 100 nM It specifically blocks NUAK1-mediated phosphorylation of MYPT1 at Ser445 with negligible off-target effects among a comprehensive panel of 139 other kinases Cellular studies demonstrate that treatment with HTH-01-015 reduces migration of mouse embryonic fibroblasts (MEFs) suppresses proliferation in U2OS and MEF cell lines at concentrations around 10 M and significantly inhibits invasion of U2OS cells within 3D Matrigel transwell assays This compound serves as a useful research tool for investigating NUAK1-related signaling pathways in cancer biology and cellular dynamics
Apexbio Technology LLC Taxifolin 480-18-2 10mM (in 1mL DMSO)
Taxifolin (CAS number 480-18-2) a bioactive flavonoid isolated primarily from coniferous species of the Pinaceae family exhibits notable antioxidant anti-inflammatory and chemopreventive properties It functions primarily through free radical scavenging and modulation of oxidative stress pathways reducing cellular damage associated with reactive oxygen species (ROS) Taxifolin further influences various signaling cascades involved in inflammation and apoptosis regulation Due to these pharmacological attributes it is widely utilized in biomedical research exploring oxidative stress-related diseases inflammatory conditions and potential cancer therapeutic avenues For optimal stability maintain storage conditions sealed dry and cool
Apexbio Technology LLC Sotrastaurin (AEB071)(Synonyms: AEB071, Sotrastaurin, PKC inhibitor AEB071, PKC inhibitor Sotrastaurin, Sotrastaurin base, AEB-071), 10mM (in 1mL DMSO), CAS: 425637-18-9.
Sotrastaurin (AEB071 CAS 425637-18-9) is a small-molecule inhibitor targeting protein kinase C (PKC) with inhibitory activity against classical and novel PKC isoforms PKC plays an integral role in immune cell signaling influencing T-cell activation proliferation and cytokine synthesis Sotrastaurin blocks PKC-mediated pathways thereby suppressing T-cell activation proliferation IL-2 mRNA expression and NK-cell function as demonstrated in ex vivo lymphocyte assays Due to its immunoregulatory properties Sotrastaurin has potential therapeutic applications in autoimmune conditions including psoriasis
Apexbio Technology LLC (-)-MK 801 121917-57-5 10mM (in 1mL DMSO)
(-)-MK 801 (CAS 121917-57-5) is a small molecule serving as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor It crosses the blood-brain barrier binding reversibly and with high affinity to cortical membranes in a saturable regionally specific manner notably within the hippocampus (-)-MK 801 selectively inhibits depolarization responses to NMDA receptor activation leading to suppression of seizure-like neuronal activity induced by neurotoxins such as tetrodotoxin Due to these properties it has widespread use as a research tool in neuroscience particularly in investigating excitotoxicity epilepsy and neurological disorders associated with NMDA receptor dysfunction
Apexbio Technology LLC Rucaparib (free base) 283173-50-2 10mM (in 1mL DMSO)
Rucaparib (free base) (CAS 283173-50-2) also known as AG014699 or PF-01367338 is a pharmacological inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme centrally involved in DNA damage signaling and base excision repair pathways By impeding PARP activity Rucaparib compromises DNA repair capacity leading to persistent DNA strand breaks as evidenced by increased gamma-H2AX and p53BP1 foci It has demonstrated radiosensitizing properties in prostate cancer cells notably those harboring PTEN deficiency or expressing ETS gene fusion proteins due partly to inhibition of non-homologous end-joining (NHEJ) DNA repair Rucaparib serves as a tool compound in oncology research to study chemosensitization and radiosensitization strategies