Dimethyl Sulfoxide
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology
Apexbio Technology LLC NVP-AEW541 475489-16-8 10mM (in 1mL DMSO)
NVP-AEW541 (CAS 475489-16-8) is a selective small-molecule inhibitor targeting the insulin-like growth factor-I receptor (IGF-IR) kinase activity Structurally classified as a pyrrolo[2 3-d]pyrimidine derivative NVP-AEW541 effectively inhibits IGF-IR autophosphorylation disrupting downstream IGF-IR mediated signaling cascades It exhibits an IC50 of approximately 0 086 M against IGF-IR kinase In vitro research has demonstrated that treatment of ECC-1 and USPC-1 endometrial cancer cell lines with NVP-AEW541 leads to altered cell cycle progression induction of apoptosis and suppression of proliferation Furthermore NVP-AEW541 has been shown to enhance radiosensitivity specifically in PTEN wild-type cancer cell lines indicating its potential utility as an adjunctive therapeutic agent in oncology research
Apexbio Technology LLC SCR7 1533426-72-0 10mM (in 1mL DMSO)
SCR7 (CAS 1533426-72-0) is a small-molecule inhibitor targeting DNA ligase IV and to a lesser extent DNA ligase III It interacts with the DNA-binding domain of DNA ligase IV thereby diminishing its affinity for double-strand breaks (DSBs) and effectively blocking nonhomologous end-joining (NHEJ)-mediated DNA repair In cell culture models expressing inducible Cas9 SCR7-mediated transient inhibition of NHEJ promotes increased homologous-directed repair (HDR) by facilitating accumulation in the S/G2 phase SCR7 treatment in mice transiently impairs lymphocyte development due to the reversible inhibition of DNA ligase IV activity during V(D)J recombination Thus SCR7 serves as a useful tool in genome editing research to enhance precise gene editing efficiency
Apexbio Technology LLC Flumethasone 2135-17-3 10mM (in 1mL DMSO)
Flumethasone is a glucocorticoid receptor agonist functioning by binding to intracellular glucocorticoid receptors (GR) and forming a receptor-ligand complex Upon formation this complex translocates into the nucleus modulating transcriptional activity through interactions with glucocorticoid response elements (GREs) subsequently altering gene expression patterns that regulate inflammation immune responses and cellular metabolism Flumethasone is commonly used in biomedical research involving inflammatory and autoimmune disease models to investigate glucocorticoid-mediated regulatory mechanisms receptor signaling pathways and gene expression modulation Reported GR-binding assays indicate Flumethasone exhibits an IC50 value in the low nanomolar range reflecting its potent receptor affinity allowing quantitative analyses and mechanistic studies on glucocorticoid-mediated biological effects
Apexbio Technology LLC Darifenacin HBr 133099-07-7 10mM (in 1mL DMSO)
Darifenacin HBr (CAS 133099-07-7) known as UK88525 is a selective antagonist of the M3 muscarinic acetylcholine receptor (mAChR M3) It demonstrates high binding affinity (pKi 8 9) toward M3 receptors which mediate smooth muscle contraction and glandular secretion in various tissues In vitro studies reveal that darifenacin acts as a substrate of the P-gp efflux transporter at the blood-brain and blood-ocular barriers In animal models darifenacin modulates bladder contractility and reduces bladder afferent nerve activity Clinically it is employed in research focusing on disorders involving abnormal detrusor muscle activity such as overactive bladder syndrome
Apexbio Technology LLC TG003 300801-52-9 10mM (in 1mL DMSO)
TG003 (CAS 300801-52-9) is a selective inhibitor targeting the Cdc2-like kinase (Clk) family and casein kinase 1 (CK1) Specifically it demonstrates notable potency against mClk1 mClk2 and mClk4 with IC50 values of approximately 20 nM 200 nM and 15 nM respectively TG003 competitively binds with ATP at Clk1 modulating Clk-mediated phosphorylation of serine/arginine-rich (SR) proteins involved in alternative mRNA splicing Studies using HeLa cellular extracts and animal models have shown that TG003 alters splice site selection and pre-mRNA processing suggesting potential utility for investigating RNA splicing regulatory mechanisms
Apexbio Technology LLC CFTRinh-172 307510-92-5 10mM (in 1mL DMSO)
CFTRinh-172 (CAS 307510-92-5) is a small molecule inhibitor selectively targeting the cystic fibrosis transmembrane conductance regulator (CFTR) a cAMP-activated chloride channel involved in epithelial fluid transport in organs such as lung intestine and pancreas It acts by reversibly and voltage-independently inhibiting CFTR currents with a Ki in the range of 0 3 5 M Experimental studies demonstrate CFTRinh-172 rapidly blocks CFTR-mediated short-circuit currents while exhibiting minimal cross-reactivity towards other channels or transporters In animal models CFTRinh-172 reduces cholera toxin-induced intestinal fluid secretion suggesting potential applications in developing cystic fibrosis models and investigating secretory diarrheal diseases
Apexbio Technology LLC Entecavir Hydrate 209216-23-9 10mM (in 1mL DMSO)
Entecavir hydrate is an antiviral compound that acts as a reverse transcriptase (RT) inhibitor specifically targeting hepatitis B virus (HBV) infection It inhibits HBV DNA replication by interacting with the viral reverse transcriptase enzyme thus preventing the synthesis of complementary DNA from the viral RNA template Entecavir hydrate is frequently employed in antiviral studies and clinical research related to hepatitis B treatment regimens In studies involving chronic HBV-infected patients entecavir hydrate combined with peginterferon alpha-2b therapy has shown significant suppression of viral DNA levels and reduced covalently closed circular DNA (cccDNA) within hepatocytes The reported IC50 value of entecavir hydrate against HBV DNA polymerase activity typically ranges below 10 nM in cellular assay systems enabling its utility in both preclinical and clinical antiviral investigations
Apexbio Technology LLC Ronidazole 7681-76-7 10mM (in 1mL DMSO)
Ronidazole is a nitroimidazole compound exhibiting both antiprotozoal and antibacterial activities Its mechanism of action involves the generation of metabolites that interact with microbial DNA resulting in DNA damage and inhibition of nucleic acid synthesis Ronidazole is commonly employed in veterinary research settings to investigate therapeutic interventions against protozoan parasites such as Tritrichomonas foetus infections in feline models Histomonas meleagridis-mediated histomoniasis and Brachyspira hyodysenteriae-related swine dysentery It can be administered orally to experimental animal subjects for clarifying pathological mechanisms and therapeutic pathways in parasitic disease models Currently detailed IC50 data for Ronidazole remain underreported in literature
Apexbio Technology LLC R406 (free base) 841290-80-0 10mM (in 1mL DMSO)
R406 (free base CAS 841290-80-0) is a small molecule inhibitor of spleen tyrosine kinase (SYK) a non-receptor kinase expressed predominantly within hematopoietic cells As an ATP-competitive inhibitor R406 selectively binds SYK s ATP-binding domain thereby suppressing its kinase activity and downstream phosphorylation events (IC50 41 nM) In mast cells R406 inhibits Fc receptor-driven degranulation with an EC50 value of 56-64 nM In diffuse large B-cell lymphoma models it blocks SYK-dependent B-cell receptor signaling through impaired autophosphorylation at sites Y525/Y526 resulting in apoptosis This compound is orally bioavailable and serves as a research tool for hematologic malignancies and autoimmune diseases
Apexbio Technology LLC Calcitriol 32222-06-3 10mM (in 1mL DMSO)
Calcitriol the biologically active metabolite of vitamin D3 functions primarily through interaction with the intracellular vitamin D receptor (VDR) regulating transcription of genes involved in mineral homeostasis and immune responses It modulates cellular differentiation proliferation and adaptive immune functions via nuclear receptor-mediated mechanisms In vitro studies demonstrate that calcitriol dose-dependently inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF- ) and interleukin-1 (IL-1 ) secretion from human peripheral blood mononuclear cells (PBMCs) Additionally animal models indicate that calcitriol administration decreases cytokine release associated with inflammatory stimuli through intracellular calcium-dependent signaling pathways Calcitriol is widely utilized in biomedical research concerning osteometabolic regulation immune modulation and cytokine signaling networks
Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss
Medchemexpress LLC Ruxolitinib10 Mm 1 Ml In Dmso | HY-50856-10MM 1 ML IN DMS
Ruxolitinib10 Mm 1 Ml In Dmso
Apexbio Technology LLC AZD1152 722543-31-9 10mM (in 1mL DMSO)
AZD1152 (CAS 722543-31-9) is a highly selective inhibitor of Aurora kinase a family of serine/threonine kinases involved in cancer cell proliferation It preferentially targets Aurora B kinase (IC50 0 37 nM) with lesser affinity toward Aurora A (IC50 1 37 M) and exhibits no notable activity against other kinases such as JAK2 FLT3 and Abl AZD1152 induces tumor cell cycle arrest in the G2/M phase triggers apoptosis and enhances radiosensitivity in androgen-resistant prostate cancer models In vivo AZD1152 demonstrates anti-tumor potency both alone and combined with chemotherapeutics or tubulin-targeting drugs offering a valuable research tool for oncology studies