Dimethyl Sulfoxide
Apexbio Technology LLC AEBSF.HCl 30827-99-7 10mM (in 1mL DMSO)
AEBSF HCl is an irreversible serine protease inhibitor that covalently binds and inhibits several proteases including trypsin chymotrypsin plasmin and thrombin It has been applied in cellular research to study amyloid-beta (A ) production mechanisms In APP695 (K695sw)-transfected K293 cells AEBSF dose-dependently reduces A formation with an IC50 around 1 mM while in wild-type APP695-transfected HS695 and SKN695 cells it shows inhibitory effects with an IC50 of approximately 300 M Besides suppressing -cleavage AEBSF promotes -cleavage of APP In macrophage-mediated leukemic cell lysis assays incubation with AEBSF at 150 M for 6 hours achieves near-maximal protease inhibition thus impeding cell lysis
Apexbio Technology LLC Sorafenib(Synonyms: Nexavar, BAY 43-9006, BAY-43-9006, BAY439006, Sorafenib Tosylate, BAY-545-9085), 10mM (in 1mL DMSO), CAS: 284461-73-0.
Sorafenib (CAS 284461-73-0) is an orally bioavailable small molecule inhibitor targeting multiple kinases including Raf kinase as well as receptor tyrosine kinases such as VEGFR2 PDGFR FLT3 Ret and c-Kit By inhibiting Raf signaling pathways sorafenib suppresses tumor cell proliferation induces apoptosis and disrupts tumor angiogenesis In vitro studies demonstrate that sorafenib effectively inhibits Raf-mediated signaling cascades and blocks the proliferation of tumor cells Sorafenib serves as an important research tool in the study of cancer biology particularly in investigating antiangiogenic and antiproliferative mechanisms in various tumor models
Apexbio Technology LLC VS-5584 (SB2343) 1246560-33-7 10mM (in 1mL DMSO)
VS-5584 (SB2343 CAS 1246560-33-7) is a purine-based inhibitor targeting the mammalian target of rapamycin (mTOR) and all class I phosphoinositide 3-kinase (PI3K) isoforms (PI3K PI3K PI3K and PI3K ) It functions through ATP-competitive inhibition displaying IC50 values of 37 16 68 25 and 42 nmol/L against mTOR PI3K PI3K PI3K and PI3K respectively Through inhibition of PI3K and mTORC1/2-mediated substrate phosphorylation VS-5584 modulates the PI3K/mTOR signaling pathway frequently dysregulated in cancers In preclinical tumor xenograft studies VS-5584 has demonstrated dose-dependent inhibition of tumor growth and pathway signaling underscoring its utility in oncology research
Apexbio Technology LLC BMX-IN-1(Synonyms: BMX Kinase Inhibitor, ETK kinase inhibitor, BMX-IN1, BMX inhibitor, ETK inhibitor), 10mM (in 1mL DMSO), CAS: 1431525-23-3.
BMX-IN-1 (CAS 1431525-23-3) is a highly selective irreversible inhibitor targeting BMX (bone marrow kinase on chromosome X also known as ETK) a member of the Tec tyrosine kinase family BMX is prominently expressed in arterial endothelium and myeloid hematopoietic cells functioning in ischemia-induced arterial and lymphatic vessel formation processes and contributing to tumor growth In cellular models expressing Tel-BMX fusion proteins BMX-IN-1 treatment at low doses effectively reduces proliferation highlighting its potential utility in cancer research particularly prostate cancer studies
Apexbio Technology LLC MI-77301 (SAR405838) 1303607-60-4 10mM (in 1mL DMSO)
MI-77301 (SAR405838 CAS 1303607-60-4) is a selective antagonist targeting the murine double minute 2 (MDM2) protein an E3 ubiquitin ligase responsible for negatively regulating tumor-suppressor p53 via ubiquitination and degradation By inhibiting the MDM2-p53 interaction (Ki 0 88 nM) MI-77301 stabilizes p53 elevates protein levels of p53 p21 and MDM2 and induces apoptosis Preclinical studies demonstrate selective growth inhibition in tumor cell lines harboring wild-type p53 (e g SJSA-1 RS4 11 LNCaP HCT-116) and potent tumor regressions in corresponding xenograft mouse models highlighting its utility for mechanistic studies and cancer therapeutic research
Apexbio Technology LLC GW788388 452342-67-5 10mM (in 1mL DMSO)
GW788388 (CAS 452342-67-5) is a selective inhibitor targeting activin receptor-like kinase 5 (ALK5) the type I receptor for transforming growth factor-beta (TGF- ) It inhibits the kinase activity of ALK5 suppressing TGF- -mediated signaling cascades GW788388 demonstrates potent inhibition of ALK5 autophosphorylation with an IC50 of 18 nM leading to decreased Smad2 phosphorylation It also inhibits TGF- -induced epithelial-mesenchymal transition (EMT) cellular proliferation fibrosis and angiogenesis in various cell models such as NMuMG MDA-MB-231 RCC and U2OS In animal studies GW788388 ameliorates renal fibrosis in diabetic db/db mouse models highlighting its utility in investigating TGF- -driven pathophysiological processes
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 10mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC SB202190 (FHPI) 152121-30-7 10mM (in 1mL DMSO)
SB202190 (FHPI CAS 152121-30-7) is a selective MAPK inhibitor targeting specifically the p38 isoforms and with reported IC50 values of approximately 50 nM and 100 nM respectively Through inhibition of p38 signaling SB202190 has been observed to stimulate the proliferation of leukemia cell lines including THP-1 and MV4-11 via activation of ERK and C-Raf phosphorylation pathways Additionally SB202190 modulates cellular responses to genotoxic stress such as hydroxyurea-induced premature chromosome condensation and influences histone acetylation status (Lys5 of histone H4) in plant systems Such activities render SB202190 useful for investigating MAP kinase-dependent pathways in cell proliferation and stress responses
Apexbio Technology LLC Preladenant 377727-87-2 10mM (in 1mL DMSO)
Preladenant is a potent and selective antagonist targeting the adenosine A2A receptor (Ki 1 1 nM) developed from structural modifications of SCH 58261 Structurally it is a methoxy derivative carrying enhanced affinity and selectivity towards human and rat A2A receptors over A1 A2B and A3 subtypes Mechanistically Preladenant competitively blocks A2A receptor-mediated adenylate cyclase activation In preclinical studies Preladenant reduces Parkinsonian symptoms in primate and rodent models alone or in combination with L-Dopa thus widely employed in experimental research for Parkinson s disease and associated movement disorders
Apexbio Technology LLC Apatinib 10mM (in 1mL DMSO)
B2303 is a synthetic small molecule designed for biomedical research acting primarily as an inhibitor targeting specific intracellular signaling pathways involved in cell proliferation and survival It modulates intracellular signaling cascades implicated in pathological conditions such as inflammation cancer progression and aberrant cell growth B2303 serves as a molecular probe suitable for investigating intracellular processes and as a tool for dissecting signal transduction mechanisms enabling researchers to explore therapeutic targets for various diseases
Apexbio Technology LLC Methazolamide 554-57-4 10mM (in 1mL DMSO)
Methazolamide (CAS 554-57-4) is a sulfonamide-derived inhibitor of carbonic anhydrase (CA) selectively targeting isoforms CAII and CAIV with IC50 values of 8 1 nM and 80 3 nM respectively By suppressing CA activity methazolamide reduces bicarbonate ion production thus decreasing fluid secretion and intraocular pressure consequently it has clinical use in glaucoma management Recent studies indicate this compound also exhibits insulin-sensitizing properties distinct from other CA inhibitors notably reducing hepatic glucose output suggesting potential applications in diabetes research and metabolic disorders
Apexbio Technology LLC Ciprofibrate 52214-84-3 10mM (in 1mL DMSO)
Ciprofibrate is a selective agonist targeting peroxisome proliferator-activated receptor alpha (PPAR ) a nuclear receptor involved in regulating lipid metabolism and energy homeostasis Its activation promotes gene expression linked to fatty acid oxidation triglyceride reduction and cholesterol metabolism Ciprofibrate is frequently applied as a molecular tool in biomedical research to investigate mechanisms underlying dyslipidemia atherosclerosis and metabolic-related disorders Additionally due to its receptor-specific mode of action it serves as a standard experimental reference in in vitro assays and animal models assessing lipid-lowering therapeutic strategies and PPAR -dependent signaling pathways
Apexbio Technology LLC Pirfenidone 53179-13-8 10mM (in 1mL DMSO)
Pirfenidone (CAS 53179-13-8) is a small molecule antifibrotic agent exhibiting anti-inflammatory properties Mechanistically pirfenidone reduces levels of pro-inflammatory mediators notably TNF- via translational regulation independent of MAPK pathway activation It suppresses TGF- -mediated signaling and extracellular matrix protein production contributing to decreased fibrotic responses in cellular and animal models In vivo pirfenidone administration mitigates fibrosis and inflammatory cytokine expression in tissues such as lung liver and kidney Clinically pirfenidone is investigated primarily for idiopathic pulmonary fibrosis demonstrating reductions in fibrosis progression and improved functional parameters
Apexbio Technology LLC Torsemide 56211-40-6 10mM (in 1mL DMSO)
Torsemide a pyridine-sulfonyl urea derivative acts pharmacologically as a loop diuretic by selectively inhibiting the Na -K -2Cl cotransporter (NKCC2) located in the thick ascending limb of Henle s loop Through this mechanism torsemide reduces sodium chloride and water reabsorption resulting in increased urinary excretion of electrolytes and water Chemically characterized by a sulfonylurea moiety linked to pyridine functionality torsemide is utilized in pharmacological research to investigate kidney function fluid-electrolyte balance and associated physiological responses Additionally researchers employ torsemide as a tool compound to study ion transport regulation pathways and the pathophysiology underlying edema and hypertension at a molecular and cellular level