Tetrahydrofuran
Medchemexpress LLC Ro5-3335 | 30195-30-3 | 99.5% | 259.69 | 10 MG
Ro5-3335 | 30195-30-3 | 99.5% | 259.69 | 10 MG
Medchemexpress LLC Tabersonine | 4429-63-4 | MFCD28140545 | 336.43 | 50 MG
Tabersonine | 4429-63-4 | MFCD28140545 | 336.43 | 50 MG
Medchemexpress LLC (E)-1-(4-methoxyphenyl)-3-(4-morpholin-4-yl-6-nitroquinolin-2-yl)prop-2-en-1-one | 2313528-04-8 | 97.0% | C23H21N3O5 | 10MG
hnRNPK-IN-1 is a small-molecule ligand that binds heterogeneous nuclear ribonucleoprotein K (hnRNPK), disrupting hnRNPK interaction with the c-myc promoter to inhibit c-myc transcription and induce apoptosis in cell-based assays. Binding affinities were measured by SPR and MST, and the compound is supplied as a solid for research use.
- Binds hnRNPK and disrupts hnRNPK-c-myc promoter interaction.
- Inhibits c-myc transcription and induces apoptosis in HeLa cell assays.
- Measured binding affinities: SPR Kd 4.6 μM, MST Kd 2.6 μM.
- High purity (97.0%) solid, brown to orange in appearance.
- Soluble in DMSO (~5 mg/mL) with warming and sonication.
- Store powder at -20°C (long-term) and solvent solutions at -80°C when possible.
Medchemexpress LLC SID7970631 | 868224-75-3 | 98.3% | 100 MG
SID7970631 is an isoquinolinone analog and a potent, selective submicromolar SF-1 inhibitor with an IC50 of 255 nM. It is primarily used for cancer research and exhibits various cytotoxic effects in vitro.
- Potent and selective SF-1 inhibitor (IC50 = 255 nM)
- Isoquinolinone analog
- Useful in cancer research
- Exhibits half-maximal cytotoxic effect in CHO-K1 cells
- Dose-dependently inhibits luciferase expression in SF-1 assay
- Demonstrates cytotoxic effect on H295R/TR SF-1 cells and SW-13 cells
![Medchemexpress LLC 3-fluoro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide | 352336-36-8 | 99.4% | C17H12FN3O2S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000258367.png-250.jpg)
Medchemexpress LLC 3-fluoro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide | 352336-36-8 | 99.4% | C17H12FN3O2S | 10MG
HY-133511 (MLS000544460) is a selective, reversible inhibitor of Eya2 phosphatase used in biochemical and cellular research. It is supplied as a white to off-white solid (C17H12FN3O2S) with high reported purity and characterized potency for use in mechanism and preclinical studies.
- selective, reversible inhibition of Eya2 phosphatase
- high reported purity (99.42%) suitable for research assays
- characterized potency: Kd 2.0 μM and IC50 4 μM
- high solubility in DMSO (125 mg/mL) and formulatable for animal dosing
- powder storage stability: -20°C for up to 3 years
- white to off-white solid with molecular weight 341.36 g/mol
Medchemexpress LLC Eya2 phosphatase inhibitor | 352336-36-8 | 99.4% | 341.36 g/mol | C17H12FN3O2S | 5 MG
MLS000544460 is a research-grade small molecule that selectively and reversibly inhibits the Eya2 phosphatase. It reduces Eya2-mediated cell migration and has reported anti-cancer activity. The compound is supplied as a powder and as DMSO solutions, is characterized by high purity, and is intended for laboratory research use only.
- Selective, reversible inhibition of Eya2 phosphatase.
- Reported Kd ≈ 2.0 μM and IC50 ≈ 4 μM for target engagement.
- High purity (~99.4%) suitable for biochemical and cell-based assays.
- Available as powder and as ready-to-use DMSO solutions.
- Stable when stored under recommended conditions for research reagents.
- Supplied with datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Devazepide | 103420-77-5 | MFCD00864500 | ≥98.0% | 408.45 | C25H20N4O2 | 50 MG
Devazepide is an analytical reference standard of a selective cholecystokinin (CCK) receptor antagonist intended for research and assay use. It is supplied as a high-purity solid and is offered in multiple pack sizes, including a 50 mg vial. Specification details and a certificate of analysis are provided for analytical applications.
- Analytical/reference standard suitable for assay and research applications.
- Selective cholecystokinin (CCK) receptor antagonist.
- CAS 103420-77-5.
- Molecular formula C25H20N4O2; molecular weight 408.45.
- Purity ≥98.0% (HPLC).
- Available in multiple pack sizes, including 50 mg.
- Certificate of analysis and storage instructions provided.
Medchemexpress LLC Vebicorvir | 2090064-66-5 | 99.7% | 467.44 | 50 MG
Vebicorvir is a first-generation inhibitor of the hepatitis B virus (HBV) core protein. It effectively suppresses the formation of covalently closed circular DNA (cccDNA) in de novo infection models, with EC50 values ranging from 1.84 μM to 7.3 μM. This compound inhibits pgRNA, HBeAg, and HBsAg production.
- First-generation hepatitis B virus (HBV) core protein inhibitor.
- Suppresses cccDNA formation in de novo infection models.
- Inhibits pgRNA, HBeAg, and HBsAg production.
Medchemexpress LLC Linzagolix | 935283-04-8 | 99.68% | 508.42 | 100 MG
Linzagolix is a potent, non-peptide, and orally active GnRH antagonist. It can be used for research related to uterine fibroids, endometriosis, and adenomyosis.
- Potent, non-peptide, and orally active GnRH antagonist.
- Can be used for uterine fibroids, endometriosis, and adenomyosis research.
- Reduces cyst volume in a rat model of endometriosis.
- Suppresses hypothalamic-pituitary-gonadal function by reducing serum luteinizing hormone and testosterone levels.
Medchemexpress LLC Remdesivir metabolite | 1911579-04-8 | 99.6% | C15H19N6O8P | 10MG
GS-704277 is an alanine metabolite of remdesivir used as a research reference standard for antiviral metabolism and analytical studies. It is intended for metabolite identification, pharmacokinetic investigations, and development or validation of chromatographic and mass-spectrometric assays.
- High stated purity suitable for analytical applications.
- Molecular formula and weight provided for confirmation and reporting.
- Available in small research-scale pack sizes for bench studies.
- Useful for metabolite identification and pharmacokinetic work.
- Compatible with LC-MS and HPLC analytical workflows.
Medchemexpress LLC CCT369260 | 2647503-57-7 | 99.7% | 50 MG
CCT369260 is a chemical probe and an orally active B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity, exhibiting an IC50 of 520 nM for BCL6.
- Chemical probe and orally active B-cell lymphoma 6 (BCL6) inhibitor
- Exhibits anti-tumor activity
- IC50 of 520 nM for BCL6
- Significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model
- Demonstrates moderate clearance with a mean oral bioavailability of 54%
- Induces BCL6 degradation in human OCI-LY1 cells
- Shows antiproliferative activity against OCI-LY1, OCI-LY3, and SUDHL4 cells
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC ETZ (C3-CA-DTZ) | 2989379-61-3 | 99.8% | C34H28N6O6 | 100 MG
ETZ (C3-CA-DTZ) is a promising luciferase substrate, acting as a prosubstrate that can be activated in vivo by non-specific esterase. This activation enhances the brain delivery of luciferin, making it a valuable tool for research applications. It has a molecular weight of 616.62 and a purity of 99.84%.
- Promising luciferase substrate
- Activated in vivo by non-specific esterase
- Enhances brain delivery of luciferin
- For research use only
Medchemexpress LLC Rhamnocitrin | 569-92-6 | 300.26 | 5 MG
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3, and MAPK pathways. It selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons by regulating miR-185, STIM-1, NFATc3, and ERK/p38 MAPK pathways. It can be used in the study of endothelial-related inflammatory diseases and neuroprotection.
- Functions as an anti-inflammatory and antioxidant agent.
- Targets STIM-1, NFATc3, and MAPK pathways.
- Inhibits oxidative stress and inflammatory responses.
- Useful for studying endothelial-related inflammatory diseases.
- Useful for neuroprotection research.
Medchemexpress LLC Ganodermanontriol | 106518-63-2 | 472.70 | 5 MG
Ganodermanontriol is a sterol isolated from Ganoderma lucidum that induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells by expressing HO-1. It also exhibits hepatoprotective activity. It has been shown to inhibit breast cancer cell lines MCF-7 and MDA-MB-231 with IC50 values of 5.8 and 9.7 μM, respectively.
- Induces anti-inflammatory activity in damaged hepatic cells.
- Exhibits hepatoprotective activity.
- Inhibits breast cancer cell lines MCF-7 and MDA-MB-231.