Organic Acids
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 1 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound works by inhibiting p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- IC50 of 50-500 nM for p300
- Over 100-fold selectivity for p300 compared to PCAF
- Induces a senescent phenotype in human normal melanocytes at 0.1 and 1 mM concentrations
- Inhibits cyclin E expression in a dose-dependent manner
Medchemexpress LLC Apstatin TFA | 99.4% | 25 MG
Apstatin TFA is a potent aminopeptidase P (APP) inhibitor. It exhibits Ki values of 2.6 μM for rat APP and 0.64 μM for human APP. This compound has also demonstrated cardioprotective effects.
- Potent aminopeptidase P (APP) inhibitor
- Effective at 2.6 μM for rat APP
- Effective at 0.64 μM for human APP
- Shows cardioprotection
- Reduces myocardial infarct size in acute myocardial ischemia models
- For research use only
Medchemexpress LLC Lys-CoA TFA | 98.5% | 50 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). Lys-CoA TFA effectively inhibits p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- Displays >100-fold selectivity for p300 over PCAF
- Inhibits p300 HAT activity-dependent transcriptional activation
- Induces a senescent phenotype in human normal melanocytes at concentrations of 0.1 and 1 mM over 60 hours
- Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner in normal human melanocytes
- For research use only
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Medchemexpress LLC Valylleucine TFA (Val-Leu TFA) | 27530-02-5 | 99.3% | 344.33 | 5 MG
Valylleucine TFA is a polypeptide identified through peptide screening. Peptide screening serves as a research tool, primarily utilizing immunoassay to pool active peptides. This process is useful for studying protein interaction, functional analysis, and epitope screening, particularly in the development of agents.
- Identified through peptide screening
- Research tool primarily using immunoassay to pool active peptides
- Useful for studying protein interaction, functional analysis, and epitope screening
- Solutions should be aliquoted and stored to prevent inactivation from repeated freeze-thaw cycles
- If water is used as stock solution, dilute to working solution, then filter and sterilize with a 0.22 μm filter before use
Medchemexpress LLC Amg 7905 (tfa) | 00-00-0 | 99.1% | 597.58 | C27H25F6N5O2S | 5 MG
AMG 7905 TFA is the trifluoroacetate salt of AMG 7905, a potent transient receptor potential vanilloid 1 (TRPV1) antagonist used in research. It potentiates proton-enhanced TRPV1 activation while blocking capsaicin-induced channel responses, and has been used to study thermoregulation and TRP channel physiology. The compound is supplied as a high-purity research reagent for in vitro and in vivo studies.
- Potent TRPV1 antagonist activity.
- Modulates proton-enhanced channel activation and blocks capsaicin responses.
- High purity (≈99.1%).
- Provided as the trifluoroacetate (TFA) salt to aid handling and solubility.
- Available in small research pack sizes suitable for pilot studies.
- Intended for laboratory research use only.
Medchemexpress LLC Bio-AMS TFA | 1393881-52-1 | 98.0% | 685.65 | 1 MG
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. It exhibits selective activity against *Mycobacterium tuberculosis* (Mtb) and hinders fatty acid and lipid biosynthesis. It is for research use only and not sold to patients.
- Potent bacterial biotin protein ligase inhibitor.
- Selective activity against *Mycobacterium tuberculosis* (Mtb).
- Arrests fatty acid and lipid biosynthesis.
- Excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM.
- Its activity is not affected by changes to the primary carbon source.
- Inhibits growth of Mtb in Mtb-infected mouse macrophages in a concentration-dependent manner (2.5, 5 and 10 μM; 24 h).
- Shows no signs of mitochondrial toxicity.
Medchemexpress LLC Cl2e-SN-38 TFA | 99.5% | 1855.95 | C89H117F3N14O26 | 1 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) linker-payload provided as the trifluoroacetate (TFA) salt. It incorporates SN-38, the active metabolite of irinotecan, and is intended for research use in ADC development and preclinical studies.
- Highly releasable linker-SN-38 conjugate suitable for ADC research.
- Provided as the trifluoroacetate salt to aid handling and formulation.
- Molecular weight 1855.95 and formula C89H117F3N14O26.
- High purity (reported ~99.5%).
- Available in milligram-scale quantities for assay development and conjugation experiments.
Medchemexpress LLC Cl2e-SN-38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 25 MG
CL2E-SN38 TFA is a trifluoroacetate salt of an antibody-linked SN-38 conjugate used for antibody-drug conjugate (ADC) research. It acts as a topoisomerase I inhibitor and is supplied as a high-purity solid characterized for in vitro and in vivo formulation.
- Purity: 99.07% (reported on product page)
- Form: trifluoroacetate salt
- Molecular weight: 1855.95
- Chemical formula: C89H117F3N14O26
- Solubility: soluble in DMSO (example: 100 mg/mL); in vivo formulations reported at ≥2.5 mg/mL
- Storage: protect from light; store under nitrogen; in solvent: -80°C for long term
- Intended use: research reagent for ADC development and topoisomerase I inhibition studies
TARGETMOL CHEMICALS INC DEXTROROTATION NIMORAZOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dextrorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
Medchemexpress LLC NCGC00138783 TFA | 99.4% | C28H27F4N7O3S | 1 ML
NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis. It directly blocks the interaction between CD47 and SIRPα axis.
- Selective inhibitor
- Targets CD47/SIRPα axis
- IC50 of 50 μM
- Blocks CD47 and SIRPα axis interaction
Medchemexpress LLC Forigerimod trifluoroacetate | 00-00-0 | 99.9% | C117H181N34O32PS·xC2HF3O2 | 5 MG
Forigerimod TFA is a 21-amino-acid peptide fragment supplied as the trifluoroacetate salt. It acts as a CD4 T-cell modulator and has been used in research on autophagy and autoimmune disorders, including systemic lupus erythematosus. Supplied as a powder with high listed purity, it is intended for research use in cellular and immunology studies.
- 21-amino-acid peptide, TFA salt
- High purity suitable for research (listed 99.88%)
- Soluble in DMSO and water at 100 mg/mL with sonication
- Powder storage: -80°C (2 years) or -20°C (1 year)
- In solvent storage: -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC JBJ-09-063 (TFA) | 99.6% | 670.67 | 25 MG
JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor that effectively reduces EGFR, Akt, and ERK1/2 phosphorylation. It is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models and can be used for researching EGFR-mutant lung cancer. This inhibitor is remarkably effective at inhibiting cell growth, leading to a significant increase in apoptosis, and exhibits favorable pharmacokinetics properties for good efficacy upon oral dosing.
- Mutant-selective allosteric EGFR inhibitor
- Reduces EGFR, Akt, and ERK1/2 phosphorylation
- Effective against EGFR TKI-sensitive and resistant models
- Suitable for EGFR-mutant lung cancer research
- Inhibits cell growth and increases apoptosis
- Favorable pharmacokinetics properties
- Stable for good efficacy upon oral dosing
Medchemexpress LLC Apraglutide TFA | 1295353-98-8 | 98.7% | 3765.25 | 5 MG
Apraglutide TFA is a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue. It enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.
- Long-acting GLP-2 analogue
- Enhances adaptation and linear intestinal growth
- Reduces fecal fat and energy losses
- Promotes intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth