4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A, is widely used in industrial and consumer products. It acts as an orally active estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR). It promotes glioblastoma progression and can contribute to lipid deposition, dyslipidemia, obesity, and intestinal inflammation, as well as accelerating atherosclerosis progression.
- Substitute for bisphenol A.
- Orally active estrogen receptor (ER) agonist.
- Competitively binds to thyroid hormone receptors (TR).
- Promotes glioblastoma progression by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway.
- Can cause significant lipid deposition and dyslipidemia.
- Has a role in causing obesity at low doses.
- Induces intestinal inflammation by altering the intestinal microbiome.
- Accelerates the progression of atherosclerosis.