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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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BQR-695 is a PI4KIIIβ inhibitor effective against both human and Plasmodium variant PI4KIIIβ. This compound is for research use only, shows no toxicity to mature red blood cells, and induces a schizont-stage arrest.
Has an IC50 of 80 nM for human PI4KIIIβ.
Has an IC50 of 3.5 nM for the Plasmodium variant of PI4KIIIβ.
Induces schizont-stage arrest.
Exhibits cross-resistance with imidazopyrazine-resistant lines.
Causes GFP-PHOsh2 redistribution to the parasite plasma membrane, indicating PI4P depletion.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More