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Cyclopropylmethyl bromide is an intermediate Cyclopropylmethyl bromide can be used in the preparation of Firocoxib (HY-14670) Firocoxib (ML 1785713) is a potent selective orally active COX-2 inhibitor[1]
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GLP-1R modulator L7-028 is a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R) that enhances GLP-1 binding via a transmembrane site. Supplied as a solid or as a 10 mM solution in DMSO for research use, it demonstrates activity in the low micromolar range and is provided with high purity.
Enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).
High purity, approx. 99.5%.
Available as solid and as 10 mM solution in DMSO.
Soluble in DMSO at 100 mg/mL; ultrasonic recommended for dissolution.
Stable under recommended storage: powder -20°C for long term; solution -80°C for extended storage.
Intended for research use only; not for human or veterinary use.
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Thioacetamide (TAA) is a hepatotoxin frequently used for experimental purposes which produces centrilobular necrosis after a single dose administration Thioacetamide can be used to induce animal models of Cirrhosis
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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FURA-2AM (CAS 108964-32-5) is a cell-permeable fluorescent calcium indicator widely employed in intracellular Ca measurements through ratiometric fluorescence microscopy Chemically it is the acetoxymethyl ester derivative of FURA-2 enhancing membrane permeability and enabling active transport into live cells Upon cytosolic entry intracellular esterases cleave its ester groups converting it into active FURA-2 which binds free Ca ions with 1 1 stoichiometry Ca binding induces a measurable excitation wavelength shift from 380 nm (Ca -free) to 340 nm (Ca -bound) while emission remains constant around 510 nm FURA-2AM s ratiometric measurement reduces artifacts from cell variability probe leakage and photobleaching making it a standard fluorescent probe in calcium signaling studies
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