Phenylpropanoids and polyketides
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Medchemexpress LLC 3-Methoxyflavone | 7245-02-5 | 99.9% | 252.26 | 50 MG
3-Methoxyflavone is a flavonoid compound that has been isolated from Artemisia incanescens. It exhibits antiviral activity and can inhibit human BCRP (Breast Cancer Resistance Protein) expressed in MDCK2 cells. It is available as an off-white to light yellow solid.
- Isolated from Artemisia incanescens.
- Exhibits antiviral activity.
- Inhibits human BCRP expressed in MDCK2 cells.
- Available as an off-white to light yellow solid.
Cayman Chemical LuteolIn 7-O-RutInosIde 10mg
A flavonoid glycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay from 1-50 µM; active against various bacteria (MICs = 100-200 UG/ml); active against C. albicans, S. cerevisiae, and C. lusitaniae (MICs = 100, 200, and 50 UG/ml, respectively); decreases hepatic and renal injury and increases survival in a mouse model of polyphosphate-induced lethal endotoxemia at 57.6 UG/animal
Medchemexpress LLC 3-Nitrocoumarin | 28448-04-6 | 100.0% | 191.14 | 1 ML
3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway. This compound causes morphological changes of apical hyperbranching in *N. crassa* hyphae.
- Inhibits phospholipase C, affecting the calcium signaling pathway.
- Inhibits glucose-induced increase of intracellular calcium ions in yeast strain WPY260 (at 50 mg/mL for 6 min).
- Inhibits PLC in *Neurospora crassa* with an IC50 of 10 μg/mL.
- Inhibits the growth of *N. crassa* and causes morphological changes of apical hyperbranching in hyphae.
Cayman Chemical ANTIBODY CoumarIn 6 5g
An acid-sensitive fluorescent probe; upon protonation, it displays a shift in emission maxima from 410 nm to 510 nm upon excitation at 157 nm; has been commonly used in photolithography
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 1 ML
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, a potent antagonist of the chemokine receptor CXCR3. This product is intended for research use only.
- Acts as an antagonist of the chemokine receptor CXCR3
- High purity (99.94%)
- S-enantiomer form
- Suitable for research applications
Medchemexpress LLC m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
Cayman Chemical Apigenin Inhibitors
Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression
Cayman Chemical EUK 118 Neurochemicals
A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134