Phenylpropanoids and polyketides
Medchemexpress LLC 4-Methoxycinnamic acid | 830-09-1 | 178.19 | 1 ML
4-Methoxycinnamic acid | 830-09-1 | 178.19 | 1 ML
Medchemexpress LLC Tyrphostin AG 879 | 148741-30-4 | 99.3% | 316.46 | 1 ML
Tyrphostin AG 879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, demonstrating at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 exhibits anticancer activity.
- Tyrosine kinase inhibitor.
- Inhibits TrKA phosphorylation (IC50 of 10 μM).
- Selective ErbB2 tyrosine kinase inhibitor (IC50 of 1 μM), with >500-fold selectivity over EGFR.
- Possesses anticancer activity.
- Significantly and dose-dependently decreases cell proliferation in various cell lines (e.g., HL-60, U-937, PC-3) in vitro.
- Induces a dose-dependent increase in apoptosis in several cell lines in vitro.
- Reduces tumor sizes in athymic, immunodepressed NOD/SCID female mice in vivo.
Abcam Epothilone D, Microtubule-stabilizing agent, 2MG
MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 2H-1-Benzopyran-2-one, 7-ethoxy-4-methyl- | 87-05-8 | MFCD00016971 | 99.4% | 10 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative that can be used as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6. It is for research use only.
- Coumarin derivative
- Substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6
- Solid appearance
- White to off-white color
Medchemexpress LLC 7-Hydroxycoumarin-4-acetic acid | 6950-82-9 | MFCD00037563 | 5 G
7-Hydroxycoumarin-4-acetic acid is a pH-indicator dye that covalently binds to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm). It is for research use only.
- Molecular weight: 220.18
- Formula: C11H8O5
- Appearance: Solid
- Color: White to off-white
- Emission (Em): 450
- Excitation (Ex): 415
Medchemexpress LLC Alogliptin benzoate | 850649-62-6 | MFCD09833195 | 99.3% | 461.51 | C25H27N5O4 | 10 MG
Alogliptin benzoate (analytical standard) is the benzoate salt of the DPP-4 inhibitor alogliptin, provided as a high-purity reference material for analytical testing, method development, and assay validation. Supplied as a small solid quantity, it is suitable for chromatographic and mass spectrometry workflows.
- High purity, typically 99.3%.
- Provided as a solid in small, accurately measured quantities.
- Suitable for HPLC and LC-MS method development and validation.
- White to off-white crystalline powder, easy to handle.
- Characterized by CAS 850649-62-6 and molecular formula C25H27N5O4.
Medchemexpress LLC Myricetin-3-O-rutinoside | 41093-68-9 | 1 MG
Myricetin-3-O-rutinoside is a natural product that can be isolated from Picea abies. It exhibits antineuroinflammatory activity in human BV-2 cells by inhibiting LPS-induced NO production.
- Purity: 96.98%
- Appearance: Solid
- Color: Light yellow to yellow
- Molecular weight: 626.52
- Formula: C27H30O17
- Structure classification: Flavonoids, Flavonols
- Initial source: Plants, Pinaceae, Picea abies (L.) H. Karsten
- Solubility (in vitro): Ethanol: 25 mg/mL (39.90 mM; requires ultrasonic)
Medchemexpress LLC (E)-m-Coumaric acid | 14755-02-3 | 1 ML
(E)-m-Coumaric acid (3-Hydroxycinnamic acid) is an aromatic acid highly abundant in food that acts as an antioxidant. It is categorized as an endogenous and microbial metabolite, targeting metabolic enzyme/protease pathways, and is intended for research use only.
- Aromatic acid highly abundant in food
- Acts as an antioxidant
- Categorized as an endogenous metabolite
- Categorized as a microbial metabolite
- Targets metabolic enzyme/protease pathways
- Purity of 99.74%
- Appearance as an off-white to yellow solid
- Molecular formula C9H8O3
- Molecular weight 164.16
- Solubility in DMSO: 100 mg/mL
- Recommended storage at 4°C, protected from light
Medchemexpress LLC 3-carboxy-6-hydroxycoumarin | 56437-16-2 | MFCD16295011 | 99.9% | 206.15 g/mol | C10H6O5 | 1 ML
3-Carboxy-6-hydroxycoumarin is a coumarin-derived intermediate used in organic synthesis and chemical research. It is supplied in both solid form and as a 10 mM solution in DMSO for use in screening, synthesis, and analytical workflows.
- High purity, typically around 99.9%.
- Molecular formula C10H6O5 and molecular weight 206.15 g/mol.
- Available as a white to yellow solid and as a 10 mM solution in DMSO.
- Solid pack sizes commonly include 25 mg, 50 mg, 100 mg, 200 mg, and 500 mg.
- Storage recommendations: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
- In solvent, store at -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 200 MG
Daunorubicin hydrochloride is a potent topoisomerase II inhibitor and anthracycline antibiotic with significant anti-tumor activity. It inhibits DNA and RNA synthesis, acting as a cytotoxin that reduces cancer cell viability and induces apoptosis and necrosis. It is used in research for various cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor, as well as infection studies.
- Inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.
- Exhibits chemosensitivity in Molt-4 and L3.6 cells.
- Induces apoptosis and necrosis in L3.6 cells.
- Triggers ROS generation in L3.6 cells.
- Induces autophagy in K562 cells.
Medchemexpress LLC Nicotiflorin | 17650-84-9 | 594.52 | 1 ML
Nicotiflorin is a flavonoid glycoside extracted from the traditional Chinese medicine *Carthamus tinctorius*. It exhibits potent antiglycation activity and neuroprotection effects.
- Flavonoid glycoside
- Extracted from Carthamus tinctorius
- Potent antiglycation activity
- Neuroprotection effects
- Attenuates cell death and reduces LDH release in cultured neurons
- Increases eNOS activity, mRNA, and protein levels in cultured rat cerebral blood vessel endothelial cells
- Reduces brain infarct volume and neurological deficits in rats following cerebral ischemia
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 100 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone and has potential for research into hepatic steatosis and dyslipidemia.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
- Molecular weight: 240.25
- Formula: C15H12O3
- Appearance: white to light yellow solid
- Purity: 99.75%
- Soluble in DMSO (100 mg/mL)
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Luteolin-3′,7-diglucoside | 52187-80-1 | 1 MG
Luteolin-3′,7-diglucoside is a glycoside isolated from *R. luteolin* that significantly inhibits cataracts induced in ovine lenses and inhibits the activity of *Ureaplasma urealyticum* ATCC and clinical strains. It works by counteracting IL1-induced tissue factor expression in monocytes, thus inhibiting procoagulant activity. This compound also demonstrates a significant ability to inhibit cataracts in ovine lenses when incubated in hypotonic hepes buffered solution.
- Molecular weight: 610.52
- Formula: C₂₇H₃₀O₁₆
- Appearance: Solid
- Color: Light yellow to yellow
- Structure classification: Flavonoids, isoflavones
- Initial source: Plants, Solanaceae, *Alkekengi officinarum Moench*
- Inhibits procoagulant activity in monocytes
- Significantly inhibits cataracts induced in ovine lenses
- Inhibits *Ureaplasma urealyticum* activity