Phenylpropanoids and polyketides
Sigma Aldrich Fine Chemicals Biosciences Xanthohumol from hop Humul5MG
Xanthohumol is a chalcone compound present in the female inflorescence of hop (Humulus lupulus) plant. It is a food additive.
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 10mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
Apexbio Technology LLC (-)-Epigallocatechin gallate (EGCG) 989-51-5 500mg
(-)-Epigallocatechin gallate (EGCG CAS 989-51-5) is a major catechin component derived from green tea comprising approximately 59% of total catechins EGCG exhibits antioxidant antiangiogenic antitumor and antiviral properties by modulating cellular signaling pathways involved in apoptosis induction cell cycle arrest and tumorigenesis inhibition It suppresses viral replication in pathogens including HCV HIV-1 HBV HSV-1/2 EBV adenovirus influenza virus and enterovirus and inhibits enzyme targets such as DNA methyltransferases (DNMTs) proteases and DHFR EGCG is utilized widely in biomedical research examining chemoprevention mechanisms and therapeutic potential in cancers such as hepatic gastric dermal pulmonary breast and colorectal malignancies
AdipoGen Rutin trihydrate
Chemical. CAS 250249-75-3. Formula C27H30O16 . 3H20. MW 610.5 . 54.0. Isolated from Ruta graveolens. Antioxidant. Free radical scavenger. Nitric oxide NO scavenger. Anticancer compound. Antiproliferative. Apoptosis inducer. Reduces induced DNA damage. Protective against carcinogenesis. Hypolipidaemic. Reduces triacylglycerol levels. Anti-inflammatory. Platelet aggregation inhibitor. Anti-hyperglycaemic. Anti-adipogenic. Insulin-mimetic. Activates synthesis of glucose transporter GLUT4. Neuroprotective. Cardioprotective. Reduces lipid peroxidation. Weak alpha-glucosidase inhibitor. Vasodilatory compound.
Medchemexpress LLC Sodium benzoate | 532-32-1 | MFCD00012463 | 99.6% | 144.10 g/mol | C7H5NaO2 | 5g
Sodium benzoate is an orally active pharmaceutical excipient such as an antibacterial agent preservative lubricant etc Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations which can improve the stability solubility and processability of pharmaceutical preparations Pharmaceutical excipients also affect the absorption distribution metabolism and elimination (ADME) processes of co-administered drugs Sodium benzoate activates NF- B and induces Apoptosis Sodium benzoate induces immune suppression and produces reproductively toxic Sodium benzoate can be used for colon cancer and immune disease research[1][2][3][4][5]
AdipoGen FK-506 Tacrolimus
Chemical. CAS 109581-93-3. Formula C44H69NO12 . H2O. MW 804.0 . 18.0. Isolated from Streptomyces FCZ0311. Potent immunosuppressant as cyclosporin A and rapamycin. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Forms a complex with FK-506 binding protein 12 FKBP12. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin, leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2 release compound. NF-kappaB suppressor by induction of unfolded protein response UPR. Anti-cancer compound. Apoptosis inducer.
eMolecules 2-Phenylpropionic acid | 492-37-5 | MFCD00002650 | 1g
Oakwood Chemical | 2-Phenylpropionic acid | 1g | 537702824 | 093725 | | 492-37-5 | MFCD00002650 | 150.177 | C9H10O2
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Medchemexpress LLC Benzyl benzoate | 120-51-4 | 99.9% | 100 G
Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. It is also an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals, and the food industry.
- Orally active anti-scabies agent, acaricide, and fungicide
- Functions as an angiotensin II (Ang II) inhibitor
- Exhibits antihypertensive effects
- Applicable in perfumes, pharmaceuticals, and the food industry
- Inhibits Ang II activity in 293T cells in a dose-dependent manner
- Significantly inhibits Ang II-induced hypertension in mice
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 50mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts