Curcumin (diferuloylmethane) is a natural phenolic research reagent that functions as a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase. It modulates NF-κB and MAPK pathways, stabilizes Nrf2 through Keap1 cysteine modification, and exhibits anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Supplied as a characterized powder with recommended storage conditions and a COA.