Phenylpropanoids and polyketides
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Apexbio Technology LLC Cinnamic acid 621-82-9 200mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
![eMolecules 1121-22-8 | trans-1,2-Diaminocyclohexane | Oakwood Chemical228.384 | C12H28N4 | 98.000 | N[C@H]1CCCC[C@@H]1N.N[C@@H]1CCCC[C@H]1N | 100g | 537673037](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3807285.JPG-250.jpg)
eMolecules 1121-22-8 | trans-1,2-Diaminocyclohexane | Oakwood Chemical228.384 | C12H28N4 | 98.000 | N[C@H]1CCCC[C@@H]1N.N[C@@H]1CCCC[C@H]1N | 100g | 537673037
trans-1,2-Diaminocyclohexane | Oakwood Chemical | 1121-22-8228.384 | C12H28N4 | 98.000 | N[C@H]1CCCC[C@@H]1N.N[C@@H]1CCCC[C@H]1N | 100g | 537673037
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | MFCD00016762 | 100 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It induces apoptosis and inhibits the production of MCP-1 and NO. This compound exhibits anticancer activity against glioblastoma and possesses anti-inflammatory and anti-allergic properties. Intended for research use only.
- Induces apoptosis in glioblastoma cells.
- Inhibits production of MCP-1, TNF-α, and NO in macrophages.
- Increases adiponectin mRNA levels and protein secretion in adipocytes.
- Reduces eosinophilic airway inflammation and airway hyperresponsiveness.
- Suppresses Th2 cytokine production and reduces mucus overproduction.
- Reduces tumor volume and weight in glioblastoma xenograft models.
- Increases plasma adiponectin levels in diabetic mice.
- Inhibits anaphylactic response to IgE-mediated passive cutaneous anaphylaxis.
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 5 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent. It also possesses antioxidant and anti-inflammatory activities, and can improve adipocyte functions. It inhibits histamine release from rat peritoneal mast cells.
- Anti-allergic agent: Inhibits histamine release from mast cells and reduces ear-swelling in allergic mice.
- Antioxidant activity: Demonstrated antioxidant properties.
- Anti-inflammatory activity: Inhibits production of TNF-alpha, MCP-1, and nitric oxide by LPS-stimulated macrophages.
- Adipocyte function improvement: Enhances adiponectin production and stimulates PPARγ activity.
- High purity: 98.87%.
- Appearance: Solid, light yellow to yellow.
- Molecular weight: 272.26.
- Chemical formula: C15H12O5.
- Initial source: Plants (Solanaceae, *Solanum lycopersicum L.*).
eMolecules 73692-50-9 | Medchem Express | Naringenin chalcone | 5mg | 592903624 | HY-N3007 | MFCD00016762 | 272.256 | C15H12O5
Medchem Express | Naringenin chalcone | 5mg | 592903624 | HY-N3007 | 73692-50-9 | MFCD00016762 | 272.256 | C15H12O5
Selleck Chemical LLC Xanthohumol
Xanthohumol a prenylated chalcone from hop inhibits COX-1 and COX-2 activity and shows chemopreventive effects Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 M Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses Xanthohumol induces growth inhibition and apoptosis in cancer cells Phase 1
Apexbio Technology LLC Cinnamic acid 621-82-9 100mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Apexbio Technology LLC Epothilone A 152044-53-6 25mg
Epothilone A (CAS 152044-53-6) is a natural macrolide compound originally isolated from the myxobacterium Sorangium cellulosum It exerts its biological activity by stabilizing microtubules thereby disrupting microtubule dynamics required for cell division In vitro Epothilone A exhibits potent cytotoxicity against human cancer cell lines with an IC50 of 4 4 nM in HCT-116 colorectal carcinoma cells In SKOV-3 ovarian cancer cells the reported IC50 is 20 4 1 4 nM and antiproliferative activity surpasses that of paclitaxel in prolonged exposure assays Epothilone A research applications include elucidating mechanisms of microtubule stabilization and investigating antitumor effects in preclinical cancer models
Medchemexpress LLC Coumarin 6 | 38215-36-0 | 100 MG
Coumarin 6 is a fluorescent dye used as a fluorescent probe within microparticle drug delivery systems. It is designed for research use only and not sold to patients.
- Fluorescent dye for microparticle drug delivery systems
- Used for in vivo tracking
- Supports cell uptake studies
- Aids research into transport mechanisms of drug delivery systems
- Excitation wavelength: 450 nm
- Emission wavelength: 505 nm
Medchemexpress LLC Myricetin-3-O-rutinoside | 41093-68-9 | 1 MG
Myricetin-3-O-rutinoside is a natural product that can be isolated from Picea abies. It exhibits antineuroinflammatory activity in human BV-2 cells by inhibiting LPS-induced NO production.
- Purity: 96.98%
- Appearance: Solid
- Color: Light yellow to yellow
- Molecular weight: 626.52
- Formula: C27H30O17
- Structure classification: Flavonoids, Flavonols
- Initial source: Plants, Pinaceae, Picea abies (L.) H. Karsten
- Solubility (in vitro): Ethanol: 25 mg/mL (39.90 mM; requires ultrasonic)
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 25 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that exhibits antioxidant and anti-inflammatory properties. It can enhance adipocyte functions and inhibits the release of histamine from rat peritoneal mast cells.
- Anti-allergic agent: orally active and inhibits histamine release from rat peritoneal mast cells.
- Antioxidant activity: possesses antioxidant properties.
- Anti-inflammatory activity: demonstrates anti-inflammatory effects.
- Adipocyte function improvement: can improve the functions of adipocytes.
- PPARγ stimulation: stimulates the activity of PPARγ in NIH-3T3 cells.
- Inhibition of inflammatory mediators: inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages.
- Suppresses allergic asthma: inhibits the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | 50 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It induces apoptosis, inhibits the production of MCP-1 and NO, and exhibits anticancer activity against glioblastoma. It also possesses anti-inflammatory and anti-allergic properties.
- Induces apoptosis
- Inhibits the production of MCP-1 and NO
- Exhibits anticancer activity against glioblastoma
- Has anti-inflammatory and anti-allergic properties